Evaluation of antinociceptive, anti-inflammatory and anxiolytic activities of methanolic extract of Terminalia citrina leaves

Das, Narhari; Goshwami, Durajan; Hasan, Md. Sharif; Mahmud, Zobaer Al; Raihan, Selim; Sultan, Md. Zakir

doi:10.1016/s2222-1808(15)60875-1

Cited by 14 publications

(10 citation statements)

References 9 publications

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“…However, an earlier report confirmed that the leaves of Terminalia citrina (Roxb.) do not possess any antimicrobial properties due to the low concentration of bioactive compounds within its leaf extract [25].…”

Section: Discussionmentioning

confidence: 99%

“…The plant reportedly possesses antioxidant and anticonvulsant activity [19], analgesic, and anti-inflammatory activity [20], anthelmintic action [21], antibacterial, antidiarrheal, diuretic and anti-spasmodic activity [22], antipyretic [23], and anti-nociceptive activity [24]. On the other hand, Terminalia citrina ex Fleming (Bengali name: Haritaki) belongs to the family Combretaceae is wide-spread available throughout the forest areas of Bangladesh [25]. The plant leaves have antioxidant properties [25], while the fruit is traditionally used in long-term fever, loss of appetite, and as a sexual stimulant in Bangladesh [26].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, Terminalia citrina ex Fleming (Bengali name: Haritaki) belongs to the family Combretaceae is wide-spread available throughout the forest areas of Bangladesh [25]. The plant leaves have antioxidant properties [25], while the fruit is traditionally used in long-term fever, loss of appetite, and as a sexual stimulant in Bangladesh [26]. In Iran, the plant is used in diarrhea, helminths, and other digestive disorders [27].…”

Section: Introductionmentioning

confidence: 99%

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In-vitro cytotoxic and anti-Vibrio cholerae activities of alcoholic extracts of Desmodium triflorum (L.) whole plant and Terminalia citrina (Roxb.) fruits

et al. 2021

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Background The majority of epidemic Vibrio cholerae strains have become resistant to multiple antimicrobial agents for many reasons, including mutations, horizontal gene transfers, etc. Therefore, secondary means of treatment are needed to overcome this impediment in combating cholera. Desmodium triflorum (L.) and Terminalia citrina (Roxb.) are extensively used in traditional medicine. Therefore, the present study aims to evaluate the antibacterial activity of methanolic and ethanolic extracts of Desmodium triflorum (L.) whole plant and Terminalia citrina (Roxb.) fruits against V. cholerae isolates. Methods Initially, different extracts of both plant materials were subjected to qualitative phytochemical screening. Anti-V. cholerae activities were assessed by performing MIC (minimum inhibitory concentration) test using disc diffusion method with different concentrations (1.25, 2.50, 8.00, 10.00, 12.50, 15.00 mg/ml) where standard discs of gentamycin and meropenem (10 μg/disc) were used. Further, Brine shrimp lethality bioassay was done to evaluate the extracts’ cytotoxic activities using different concentrations (800, 400, 200, 100, 50, 25, 12.5, 6.25 μg/ml) against vincristine sulphate. Results The preliminary screening confirms the presence of convenient phytochemical constituents like flavonoids, alkaloids, glycosides, tannins, etc., and are liable for the emergence of the antibacterial activities in different strains. The minimum inhibitory concentrations of both methanolic and ethanolic extracts of Terminalia citrina (fruits) and Desmodium triflorum (L.) (whole plant) were found to be 2.50 mg/ml and 5 mg/ml, respectively. Moreover, 100% mortality was observed only in ethanolic extract of Terminalia citrina fruits at the highest concentration (800 μg/ml). In comparison, the rest of the test extracts showed less than 90% mortality at the highest concentration (800 μg/ml). Conclusions Both plants possess significant phytoconstituents and showed appreciable anti-V. cholerae activities with mild toxicity. Hence, Desmodium triflorum (L.) whole plant and Terminalia citrina (Roxb.) fruits may be recommended as potential phytotherapy against cholera disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In-vitro cytotoxic and anti-Vibrio cholerae activities of alcoholic extracts of Desmodium triflorum (L.) whole plant and Terminalia citrina (Roxb.) fruits

et al. 2021

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“…The percentage membrane stabilizing activity was determined using the equation shown below. 20 Naproxen was used as standard.…”

Section: Preparation Of Red Blood Cellsmentioning

confidence: 99%

A detailedin vitrostudy of naproxen metal complexes in quest of new therapeutic possibilities

Hasan

Das

2017

Alexandria Journal of Medicine

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The present study was designed to investigate the in vitro anti-inflammatory, antimicrobial, cytotoxic and antioxidant effects of Naproxen metal complexes. Methodology: The anti-inflammatory activity was evaluated by HRBC membrane stabilization method while antimicrobial activity by disk diffusion method. The cytotoxicity was evaluated by brine shrimp lethality bioassay and compared with vincristine sulfate. Antioxidant potential was evaluated in terms of DPPH radical scavenging potential, ABTS scavenging potential, reducing power assay, superoxide dismutase assay and total antioxidant capacity by specific standard procedures. Results: The Naproxen metal chelates showed significant anti-inflammatory effects in dose dependent manner. Naproxen standard showed maximum inhibition occurred 73.21% at the dose of 2000 lg/ml. Among Naproxen metal chelates, Naproxen silver complex showed potent antimicrobial activity against most of the tested microorganisms while Naproxen zinc complex showed better activity against gram positive strains than gram negative. In brine shrimp lethality bioassay, varying degree of lethality to Naproxen metal chelates was observed showing Naproxen iron complex surprisingly very potent cytotoxic activity compared to vincristine sulfate where other metal complexes displayed reduced cytotoxicity than parent Naproxen while Naproxen exhibited the lowest antioxidant assay among all the metal complexes compared to the standard ascorbic acid. Conclusion: The present study demonstrated that Naproxen and its complexes possess in vitro anti-inflammatory activity while silver, zinc and iron complexes possess higher antimicrobial and cytotoxic properties than the parent ligand and possess very mild antioxidant activity.

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“…Two different doses (25 and 50 mg/kg) of the naproxen metal derivatives were administered orally to different groups of 6 animals each, 45 min prior to experiment. Each mouse was placed individually at the center of elevated plus maze with its head facing toward an open arm and observed for 5 min to record the number of entries into open arm and closed arm and time spent in each arm [ 13 ]. Diazepam (2 mg/kg, p.o.)…”

Section: Biological Evaluationmentioning

confidence: 99%

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

Hasan

Das

Mahmud

et al. 2016

Advances in Pharmacological Sciences

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Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen metal complexes was assessed using phenobarbitone-induced sleeping time test and the hypoglycemic test was performed using oral glucose tolerance test. Results. Metal complexes significantly (P < 0.001) reduced the number of abdominal muscle contractions induced by 0.7% acetic acid solution in a dose dependent manner. At the dose of 25 mg/kg body weight p.o. copper, cobalt, and zinc complexes exhibited higher antinociceptive activity having 59.15%, 60.56%, and 57.75% of writhing inhibition, respectively, than the parent ligand naproxen (54.93%). In tail-flick test, at both doses of 25 and 50 mg/kg, the copper, cobalt, silver, and zinc complexes showed higher antinociceptive activity after 90 minutes than the parent drug naproxen. In elevated plus maze (EPM) model the cobalt and zinc complexes of naproxen showed significant anxiolytic effects in dose dependent manner, while the copper, cobalt, and zinc complexes showed significant CNS depressant and hypoglycemic activity. Conclusion. The present study demonstrated that copper, cobalt, and zinc complexes possess higher antinociceptive, anxiolytic, CNS depressant, and hypoglycemic properties than the parent ligand.

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Evaluation of antinociceptive, anti-inflammatory and anxiolytic activities of methanolic extract of Terminalia citrina leaves

Cited by 14 publications

References 9 publications

In-vitro cytotoxic and anti-Vibrio cholerae activities of alcoholic extracts of Desmodium triflorum (L.) whole plant and Terminalia citrina (Roxb.) fruits

In-vitro cytotoxic and anti-Vibrio cholerae activities of alcoholic extracts of Desmodium triflorum (L.) whole plant and Terminalia citrina (Roxb.) fruits

A detailedin vitrostudy of naproxen metal complexes in quest of new therapeutic possibilities

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

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