Evaluation of Antioxidant Activity of Flavonoid and Phenolic Contents of Luffa Echinata Roxb. Fruits and Nyctanthus Arbor-Tristis Leaves

Modi, Anuj; Kumar, Vijay; Jain, Prateek; Jain, Sunil; Uplanchiwar, Vaibhav

doi:10.7439/ijpp.v1i1.158

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…The proliferation of the cancer cell lines MCF-7 and HT-29 was successfully inhibited by a methanolic extract of fruit. [64] Similarly, hydroalcoholic (50%) [65] and hydromethanolic (80%) [66] extract of dried fruit was also asserted to have a high content of total flavonoid and total phenolic compounds and possess better antioxidant activity in ORAC, TEAC, and DPPH free radical scavenging activity assay as well as in lipid peroxidation and possessed hydroxyl radical scavenging activity.…”

Section: Whole Plantmentioning

confidence: 98%

An Insight into the Elusive Healer Plant “Luffa echinata Roxb.”

Mondal¹,

Bhar²,

Kumari³

et al. 2022

Pharmacogn. Res.

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Recent years have seen a global rise in the use of herbal medicine. Many naturally occurring bioactive substances, especially those derived from plants, have been studied as potential cures for various diseases. Luffa echinata Roxb., a mysterious medicinal plant from the Cucurbitaceae family, has recently gained recognition as one of the most important medicinal herbs among them. Many phytochemicals found in this plant have been found to have therapeutic potential, including xanthones, alkaloids, phytosterols, flavonoids/isoflavonoids, chalcone, glycosides, terpenoids, saponins, carbohydrates, proteins, reducing sugars, fatty acids, tannins, and phenolic compounds. Other potent phytoconstituents of this plant include saponins, hentriacontane, gypsogenin, sapogenin, cucurbitacin (A, B, C, D, E, K, S, and I), β-sitosterol, echinatol (A and B), oleanolic acid, isoquercetin, quercimeritrin, and sitosterol glycoside. Cucurbitacin, a prominent class of triterpenoids found in L. echinata, has been proven effective in numerous reports. Recent research has shown that cucurbitacins can decapitate or inhibit the proliferation of cancer cells. Luffa echinacea's fruit and leaves have long been used as purgatives and to cure liver disease, hemorrhoids, jaundice, migraines, emesis, and other conditions by Indian and Chinese physicians. Ulcers and sores have also been expelled using them. During the field study, it was found that the tribal community (Tharus) of Khatima utilized extremely bitter, squeezed fruit stuff given to sufferers of dog bites in the morning on an empty stomach, and more than 500 people have been adequately treated thus far. The therapeutic potential and phytoconstituents of Luffa echinata have been clarified by pharmacological and phytochemical studies; further study is required to investigate these phytoconstituents and their structures.

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Section: Whole Plantmentioning

confidence: 98%

An Insight into the Elusive Healer Plant “Luffa echinata Roxb.”

Mondal¹,

Bhar²,

Kumari³

et al. 2022

Pharmacogn. Res.

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“…[10] Quantitative analysis was carried out for total flavonoid and phenolic content and in vitro antioxidant activity of MNAT was estimated using DPPH assay. [11] Total flavonoid content Flavonoids were determined using the aluminium chloride colorimetric technique. MNAT (0.5 ml of 1:20 g/ml) in methanol was combined with 11.5 ml of methanol, 0.1 ml of 10% aluminium chloride, 0.1 ml of IM potassium acetate and 2.8 ml of distilled water individually.…”

Section: Phytochemical Analysismentioning

confidence: 99%

Effect of Nyctanthes arbor-tristis on cardiovascular parameters and metabolic syndrome in fructose-induced hypertensive rats

Mohan

Malode

Pekhale

et al. 2022

IJPP

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Objectives: We investigated the effects of methanolic extract of Nyctanthes arbor-tristis (MNAT) 100, 200 and 400 mg/kg/day post-operative for 6 weeks on ECG, basal mean arterial blood pressure (MABP), heart rate, respiratory rate, vascular reactivity, antioxidant activities of enzyme superoxide dismutase (SOD) and catalase (CAT), levels of thiobarbituric acid reactive substances (TBARS), serum levels of leptin, adiponectin, glucose, triglycerides, cholesterol, uric acid, insulin, sodium and potassium in fructose-fed rats. Materials and Methods: A high-fructose-diet (fructose 10%, w/v) ad libitum for 6 weeks was used to induce hypertension in male Wistar rats (150–200 g). Sixty albino Wistar rats were randomly divided into a group of six, each group containing 10 animals. Group I was considered as normal control which received chow pellets and normal drinking water ad libitum for 6 weeks. Group II received fructose (10%) solution instead of normal drinking water for 6 weeks. Group III received fructose (10%) solution instead of drinking water ad libitum and MNAT at a dose of 100 mg/kg post-operative for 6 weeks. Group IV received fructose (10%) solution instead of drinking water ad libitum and MNAT at a dose of 200 mg/kg post-operative for 6 weeks. Group V received fructose (10%) solution instead of drinking water ad libitum and MNAT at a dose of 400 mg/kg post-operative for 6 weeks. Group VI received fructose (10%) solution instead of drinking water ad libitum and enalapril at a dose of 10 mg/kg post-operative for 6 weeks. Physiological parameters, ECG, heart rate, respiratory rate and blood pressure vascular reactivity to various drugs were measured and recorded by the invasive method. The antioxidant activities of enzyme SOD and CAT, levels of TBARS, along with serum levels of leptin, adiponectin, glucose, triglycerides, cholesterol, uric acid, insulin, sodium and potassium were measured. Cumulative concentration-response curve (CCRC) of Ang II and acetylcholine (Ach) was recorded. Results: MNAT treatment decreased MABP and altered vascular reactivity to various catecholamines. The activities of SOD and CAT enzymes exhibited a considerable increase and the levels of TBARS in the liver were reduced by MNAT treatment. MNAT has shown decrease in the plasma level of triglycerides, cholesterol, insulin and sodium while increase in plasma adiponectin and potassium levels. The CCRC of Ang II was shifted towards the right by MNAT treatment using an isolated strip of rat ascending colon. MNAT treatment increased the contractile characteristics of the rat ascending colon in the CCRC of ACh as compared to the fructose-treated group. MNAT treatment reduced fructose-induced tissue damage due to the consequence of metabolic syndrome (MetS). MNAT is rich in flavonoids and, therefore, has powerful antioxidant properties. The findings show that by battling oxidative stress caused by fructose (10%) and reducing Ang II activity, MNAT may be able to prevent the development of high blood pressure caused by fructose. Conclusion: MNAT has antihypertensive action and reverses MetS in the fructose-induced hypertensive rat model.

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Phyto-constituents profiling of Luffa echinata and in vitro assessment of antioxidant, anti-diabetic, anticancer and anti-acetylcholine esterase activities

Patel

Ghane

2021

Saudi Journal of Biological Sciences

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Evaluation of Antioxidant Activity of Flavonoid and Phenolic Contents of Luffa Echinata Roxb. Fruits and Nyctanthus Arbor-Tristis Leaves

Cited by 5 publications

References 9 publications

An Insight into the Elusive Healer Plant “Luffa echinata Roxb.”

An Insight into the Elusive Healer Plant “Luffa echinata Roxb.”

Effect of Nyctanthes arbor-tristis on cardiovascular parameters and metabolic syndrome in fructose-induced hypertensive rats

Phyto-constituents profiling of Luffa echinata and in vitro assessment of antioxidant, anti-diabetic, anticancer and anti-acetylcholine esterase activities

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