Evaluation of Antioxidant Activity of Zingiber Officinale (Ginger) on Formalin-Induced Testicular Toxicity in Rats

Rasyidah, T. I.; Suhana, S.; Nur-Hidayah, H.; Kaswandi, M. A.; Noah, R. M.

doi:10.12720/jomb.3.3.149-153

Cited by 13 publications

(13 citation statements)

References 20 publications

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“…The testicular tissue is provided with an antioxidant defense system including several enzymes functioning in a collective manner for the removing free radicals generated within the cell. SOD and catalase are major enzymes that get rid of reactive oxygen species (ROS) [ 26 ]. In the present study, the animals treated with arsenic showed decreased activities of testicular antioxidant enzymes, SOD, and CAT that may indicate the antioxidant imbalance induced by arsenic.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats

Bashandy¹,

Awdan²,

Ebaid

et al. 2016

Oxidative Medicine and Cellular Longevity

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The present study aimed to examine the protective role of Spirulina platensis (S. platensis) against arsenic-induced testicular oxidative damage in rats. Arsenic (in the form of NaAsO2 at a dose of 6.3 mg/kg body weight for 8 weeks) caused a significant accumulation of arsenic in testicular tissues as well as a decrease in the levels of testicular superoxide dismutase (SOD), catalase (CAT), reduced glutathione, and zinc. Moreover, it significantly decreased plasma testosterone, luteinizing hormone (LH), triiodothyronine (T3), and thyroxine (T4) levels and reduced sperm motility and sperm count. Arsenic (AS) led to a significant increase in testicular malondialdehyde (MDA), tumour necrosis factor alpha (TNF-α), nitric oxide (NO), and sperm abnormalities. S. platensis at a dose of 300 mg/kg was found to attenuate As-induced oxidative stress, testicular damage, and sperm abnormalities by its potent antioxidant activity. S. platensis may represent a potential therapeutic option to protect the testicular tissue from arsenic intoxication.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats

Bashandy¹,

Awdan²,

Ebaid

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…The SOD activity is then evaluated by the degree of inhibition of this reaction. The level of SOD was measured at 505 nm and through a standard curve and expressed as U/mg protein ( 25 ).…”

Section: Methodsmentioning

confidence: 99%

Protective effect of curcumin on lead acetate-induced testicular toxicity in Wistar rats

Sudjarwo

Koerniasari³

2017

Res Pharma Sci

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In recent years, the use of the antioxidant in reducing heavy metal toxicities has increased worldwide. Curcumin has been reported to have a strong antioxidant activity. In this study, we investigated the protective effects of curcumin on lead acetate-induced testicular damage in rats. The sample used 40 male rats divided into 5 groups: negative control (rats were given daily with corn oil); positive control (rats were given daily with lead acetate 50 mg/kg BW orally once in a day for 35 days); and the treatment group (rats were given the curcumin 100 mg, 200 mg, and 400 mg/kg BW orally once in a day for 40 days, and on the 5th day, were given lead acetate 50 mg/kg BW one h after the curcumin administration). After 40 days, levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in testicular tissue, and sperm count, motility and viability in the epididymis were measured in rats. Testis samples were also collected for histopathological studies. Results showed that lead acetate administration significantly decreased the SOD, GPx, and increased MDA levels. Lead acetate also decreased the sperm count, motility, viability, and altered histopathological testis (testicular damage, necrosis of seminiferous tubules and loss of spermatid) compared to the negative control. However, administration of curcumin significantly improved the histopathological in testis, increased the sperm count, motility, viability, and also significantly increased the SOD, GPx, and decreased MDA in testis of lead acetate-treated rats. From the results of this study we concluded that the curcumin could be a potent natural product provide a promising protective effect against lead acetate induced testicular toxicity in rats.

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“…The testes of mice induced with an antibiotic gentamicin may undergo histological damage and poptosis in the spermatogenic cells, treatment with ginger extract was able to recover such damages [19]. The strong evidence that the ginger extract is an antioxidant has shown by the increased activity of oxidase enzyme SOD (superoxide dismutase) and catalase in rat testis induced by formalin [20]. Moreover, ginger is also found to have a protective effect against H 2 O 2 -induced DNA damage, and proven to improve the quality of sperm parameters in mice [21,22].…”

Section: Resultsmentioning

confidence: 99%

Rhizome Extract of White Ginger (<i>Zingiber officinale</i> Roxb) Maintains Testicular Function of Aging Mice

Bedê¹

2016

IJNFS

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Ginger is recognized as antioxidants and chemoprotective. Therefore the rhizome extract of this plant could allegedly reverse aging process. The study is intended to investigate the possible effects of rhizome extract of white ginger (Zingiber officinale Roxb.) on the testicular function of aging male mice (Mus musculus Linn.). Male albino mice aged 12-14 months, grouped into three consisted of 12 mice, were given extract orally as follows: 0 mg/kg (as a control), 50mg/kg and 100 mg/kg daily for 70 days. The testicular function parameters assessed were: the number of spermatogenic cells, the number and quality of sperm. Compared to control group, male mice treated with ginger extract showed significant high quality of sperm count, viability, motility and morphology (P<0.001). Histological parameters of the testis: pre-leptotene as well as pachytene spermatocytes and spermatids cells also significantly higher in the treated group (P <0.01) than that of control. In conclusion, rhizome extract of ginger effectively maintain function of reproductive system of male mice in aging process and, thus, ginger is potentially as the fertility and anti-aging herbs.

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Evaluation of Antioxidant Activity of Zingiber Officinale (Ginger) on Formalin-Induced Testicular Toxicity in Rats

Cited by 13 publications

References 20 publications

Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats

Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats

Protective effect of curcumin on lead acetate-induced testicular toxicity in Wistar rats

Rhizome Extract of White Ginger (<i>Zingiber officinale</i> Roxb) Maintains Testicular Function of Aging Mice

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Evaluation of Antioxidant Activity of Zingiber Officinale (Ginger) on Formalin-Induced Testicular Toxicity in Rats

Cited by 13 publications

References 20 publications

Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats

Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats

Protective effect of curcumin on lead acetate-induced testicular toxicity in Wistar rats

Rhizome Extract of White Ginger (&lt;i&gt;Zingiber officinale&lt;/i&gt; Roxb) Maintains Testicular Function of Aging Mice

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Product

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Rhizome Extract of White Ginger (<i>Zingiber officinale</i> Roxb) Maintains Testicular Function of Aging Mice