Evaluation of antioxidant activity of Brazilian plants

SILVA, C; Herdeiro, R.S.; Mathias, C.; Panek, Anita D.; Silveira, Carla Semiramis; Rodrigues, Vanessa da Silva Tavares; Rennó, Magdalena N.; Falcão, Deborah Quintanilha; Cerqueira, Débora M.; Minto, Andréa Barreto Mattos

doi:10.1016/j.phrs.2005.03.008

Cited by 120 publications

(88 citation statements)

References 18 publications

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“…The crude extracts (25-1000 ppm) and pure compound (1-100 ppm) were tested using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (Silva et al 2005). Each solution (0.75 mL) was mixed with 0.3 mL of a 0.3 mM DPPH MeOH solution and kept in the dark at room temperature (30 min).…”

Section: Determination Of Anthocyanin Contentmentioning

confidence: 99%

Antioxidant property and α $$ \boldsymbol{\upalpha} $$ -glucosidase, α $$ \boldsymbol{\upalpha} $$ -amylase and lipase inhibiting activities of Flacourtia inermis fruits: characterization of malic acid as an inhibitor of the enzymes

et al. 2015

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Flacourtia inermis Roxb. (Flacourtiaceae), is a moderate sized tree cultivated in Sri Lanka for its fruits known as Lovi. The current study was undertaken to study the biological activity of extracts of the fruits in an attempt to increase the value of the under exploited fruit crops. Fruits of F. inermis were found to be rich in phenolics and anthocyanins. Polyphenol content of the fruits was determined to be 1.28 g gallic acid equivalents per 100 g of fresh fruit and anthocyanin content was estimated as 108 mg cyanidin-3-glucoside equivalents per 100 g of fresh fruits. The EtOAc extract showed moderate antioxidant activity in the DPPH radical scavenging assay with IC 50 value of 66.2 ppm. The EtOAc and MeOH extracts of the fruits also exhibited inhibitory activities toward α-glucosidase, α-amylase and lipase enzymes with IC 50 values ranging from 549 to 710 ppm, 1021 to 1949 ppm and 1290 to 2096 ppm, respectively. The active principle for the enzyme inhibition was isolated through activity-guided fractionation and was characterized as (S)-malic acid. The results of this study indicate that F. inermis fruits have the potential to be used in health foods and in nutritional supplements.

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Section: Determination Of Anthocyanin Contentmentioning

confidence: 99%

Antioxidant property and α $$ \boldsymbol{\upalpha} $$ -glucosidase, α $$ \boldsymbol{\upalpha} $$ -amylase and lipase inhibiting activities of Flacourtia inermis fruits: characterization of malic acid as an inhibitor of the enzymes

et al. 2015

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“…What is interesting though is that the use of plant derived remedies is still a vital area in medicinal product invention. Approximately 60% of the anti-tumoral and anti-infective agents, either commercially available or in late stages of clinical trials are of natural origin (Silva et al, 2005). However at present there is no single prescribed medication existing (with an active principle isolated or inspired by plant metabolism) on the world market that is off plant origin and as a result this puts a great emphasis on health stores to fill this niche.…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacology in Dublin: surveys on the medicinal plants use profile

Cunningham¹,

Menezes²

2011

Rev. bras. farmacogn.

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This study aimed to examine the use of natural products as medicines in the greater Dublin area, Ireland. A field study was carried out on eighteen natural health stores; store assistants were interviewed and asked questions from a previously prepared questionnaire. Results were evaluated and a picture could be drawn about the use of natural products in Dublin. Questions asked included best sellers, new products on the market, common prescribers, ailments for which product is requested. Results indicated that as much as 60% of customers requests specific products were advice from staff. Nutritionists accounted for approximately one third of the medical profession that prescribed products for sale in health stores. The survey also examined common medicinal products requested which were not available without prescription. St. John's Wort and Gingko biloba were the most requested. Undoubtly, there is a revival to searching for natural alternatives for the treatment of diseases with no medical advice.

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“…However, the n-C 6 H 14 and CHCl 3 partitions are poor sources of antioxidants. Some studies have demonstrated that the extracts of Hyptis fasciculate shown to be active as DPPH radical scavengers (Silva et al, 2005 and others Lamiaceae plants (e.g. some Salvia species, Gontscharovia popovii) represent good potential sources of natural antioxidants useful for either prevention or treatment of oxidative stress-related diseases (Firuzi et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Preliminary study on the anti-inflammatory and antioxidant activities of the leave extract of Hyptis fruticosa Salzm. ex Benth., Lamiaceae

Andrade¹,

Oliveira²,

Santos³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Avaliação das atividades anti-inflamatória e antioxidante do extrato etanólico das folhas da Hyptis fruticosa Salzm. ex Benth., Lamiaceae". Várias espécies do gênero Hyptis são utilizadas na medicina popular para tratar processos inflamatórios. Para avaliar as ações anti-inflamatória e antioxidante da Hyptis fruticosa Salzm. ex Benth., Lamiaceae, utilizou-se extrato etanólico (EE) das folhas desta planta e suas partições n-C 6 H 14 , CHCl 3 , AcOEt e MeOH/H 2 O. O tratamento oral com o EE das folhas da H. fruticosa (100, 200 e 400 mg/kg) ou suas partições n-C 6 H 14 , AcOEt e MeOH/H 2 O (50, 100 e 200 mg/kg) apresentou atividade inibitória sobre a formação de edema e migração leucocitária para a cavidade peritoneal induzidas pela carragenina em ratos (p<0,05). Entretanto, a partição CHCl 3 não causou nenhum efeito sobre a formação de edema e migração de células peritoneais. O EE bruto e a partição AcOEt apresentaram alto potencial antioxidante (IC50 = 35,00±1,01 e 36,67±2,65 μg/mL DPPH, respectivamente), similar ao composto referência (IC50 = 16,67±1,21 μg/mL). Em conclusão, demonstrou-se que a H. fruticosa apresenta atividades anti-inflamatória e antioxidante.Unitermos: Anti-inflamatória, antioxidante, edema, Hyptis fruticosa, Lamiaceae, migração celular.ABSTRACT: Various species of Hyptis are used in folk medicine as anti-inflammatory. In order to evaluate the actions of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, studies were performed on anti-inflammatory and antioxidant activities. The ethanol extract (EE) of H. fruticosa leaves and its n-C 6 H 14 , CHCl 3 , EtOAc, and MeOH/H 2 O partitions were used in the following experiments. Oral treatment with the EE of H. fruticosa leaves (100, 200, and 400 mg/kg) or its n-C 6 H 14 , EtOAc, and MeOH/H 2 O partitions (50, 100, and 200 mg/kg) elicited inhibitory activity (p<0.05) on carrageenan-induced oedema formation and leukocyte migration into the peritoneal cavity in rats. However, the CHCl 3 partition did not show any inhibitory effect on paw oedema and peritonitis experimental models. The EE and EtOAc partition present the highest antioxidant potential (IC50 = 35.00±1.01 and 36.67±2.65 μg/ mL DPPH, respectively), similar to the reference compound (IC50 = 16.67±1.21 μg/mL). In conclusion, H. fruticosa shows anti-inflammatory and antioxidant activities.

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Evaluation of antioxidant activity of Brazilian plants

Cited by 120 publications

References 18 publications

Antioxidant property and α $$ \boldsymbol{\upalpha} $$ -glucosidase, α $$ \boldsymbol{\upalpha} $$ -amylase and lipase inhibiting activities of Flacourtia inermis fruits: characterization of malic acid as an inhibitor of the enzymes

Antioxidant property and α $$ \boldsymbol{\upalpha} $$ -glucosidase, α $$ \boldsymbol{\upalpha} $$ -amylase and lipase inhibiting activities of Flacourtia inermis fruits: characterization of malic acid as an inhibitor of the enzymes

Ethnopharmacology in Dublin: surveys on the medicinal plants use profile

Preliminary study on the anti-inflammatory and antioxidant activities of the leave extract of Hyptis fruticosa Salzm. ex Benth., Lamiaceae

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