Evaluation of antioxidant and anti-atherogenic properties of<i>Glycyrrhiza glabra</i>root using<i>in vitro</i>models

Visavadiya, Nishant P.; Soni, Badrish; Dalwadi, Nirav

doi:10.1080/09637480902877998

Cited by 76 publications

(46 citation statements)

References 31 publications

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“…Studies have reported that liquorice flavonoids have 100 times strong antioxidant activity when compared with antioxidant activity of vitamin E [24]. The aqueous and ethanolic extract of Glycyrrhiza glabra also shows dose dependent oxidative scavenging activity and have potential for protective effect against the human lipoprotein oxidative system [25]. In this reported study, antioxidant activity of aerial part and root of Glycyrrhiza glabra Linn.…”

Section: Therapeutic Potentials and Traditional Usesmentioning

confidence: 77%

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Thakur¹,

Raj²

2017

JAPLR

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The Glycyrrhiza genus contains more than 30 species and widely distributed all over the world [7]. Glycyrrhiza genus plants are wide spread in Mediterranean, Southern and Central Russia and Asia, being minor to Iran. Many species are now grown throughout Europe, Syria, Asia, UK, USA, Italy, France, Germany, AbstractGlycyrrhiza glabra Linn. (Family: Fabaceae) is a traditional medicinal plant used in various ancient medicine systems and documented across the globe for its ethanopharmacological value to cure varieties of ailments. Glycyrrhizin is the major active constituent obtained from liquorice roots, one of the most widely used in herbal preparations for the treatment and management of chronic diseases. The present mini-review is focused mainly on major secondary metabolites, ethnopharmacology and potential medicinal uses of Glycyrrhiza glabra. The sources for the literature search were PubMed, ScienceDirect, SciFinder and Google Scholar. Reported pharmacological activities, characterized secondary metabolites and traditional uses of Glycyrrhiza glabra warrants its potential therapeutic uses. However, further scientific validations along with evidencebased studies are still required in support to its traditional uses, to serve as "lead" for development of novel agents and a better drug candidate in future. Keywords:

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Section: Therapeutic Potentials and Traditional Usesmentioning

confidence: 77%

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Thakur¹,

Raj²

2017

JAPLR

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“…Glycyrrhizin, the main sweet-tasting constituent of G. uralensis, has been reported to scavenge free radicals and block the chain reaction of lipid peroxidation (Binic et al, 2013). Moreover, its antioxidant, anti-inflammatory, chemopreventive, and antiproliferative activity have been reported (Rahman et al, 2007;Visavadiya et al, 2009;Binic et al, 2013).However, information on the cosmeceutical activity of G. uralensis is limited. G. uralensis extract in most research has been mainly prepared in methanol.…”

Section: Introductionmentioning

confidence: 99%

In-vitro studies on antioxidant, anti-melanogenic and anti-wrinkle effects of medicinal plant Glycyrrhiza uralensis

Ryu¹,

Kang²,

Lee³

2017

JEB

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Aim: Methodology:Results: Interpretation:The aim of the present study was to investigate the antioxidant, anti-melanogenic and anti-wrinkle activity of Glycyrrhiza uralensis (G. uralensis) for cosmeceutical application.The free radical scavenging activity of 1,3-butylene glycol (1,3-BG) extract of G. uralensis was analyzed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and oxygen radical absorbance capacity (ORAC) assays. The anti-melanogenesis and anti-wrinkle effects of G. uralensis extract were also analyzed by tyrosinase, zymography and collagen assays.The EC of 1,3-BG extract of G. uralensis, determined by DPPH and ABTS assays, was 0.59% 50 and 1.17%, respectively.The ORAC value of the extract was 41.56 μM trolox equivalent. The G. uralensis extract inhibited in vitro mushroom tyrosinase activity with an IC of 0.6%, and it also reduced melanin 50 contents in mouse melanoma cells. In addition, the G. uralensis extract notably inhibited matrix metalloproteinase-2 activity via zymography. Approximately, 60% collagen production enhancement was observed upon treatment with the extract, suggesting its anti-wrinkle potential.The 1,3-BG extract of G. uralensis may be utilized as a cosmeceutical ingredient, offering anti-oxidant, brightening and anti-wrinkle effects.

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“…[15] G. glabra (Yeshtimadhu) contain phenolic component exhibit antioxidant activity. [16] Z. officinale (Sunthi) contains many antioxidants such as beta-carotene, ascorbic acid, terpenoids, alkaloids, and polyphenols such as flavonoids, flavones glycosides, and rutin. [17] B. arundinacea (Vamshalochana) contains phenolic compounds such as phenolic acids, flavonoids, and tannins which shows the antioxidant activity of the plant.…”

Section: Research Articlementioning

confidence: 99%

Comparison the Effect of Echium Amoenum Extract With Fluoxetine on Depression in Menopausal Women. A Double-Blind Randomized Controlled Trial

Baghbadoranee

2019

AJP

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Aim: A semisolid (avaleha) herbal formulation Drakshavaleha (DKV) was prepared based on the method described in Ayurvedic Formulary of India. It contains Vitis vinifera (Draksha), Piper longum (Pippali), Glycyrrhiza glabra (Yeshtimadhu), Zingiber officinale (Sunthi), Bambusa arundinacea (Vamshalochana), Emblica officinalis (Dhatri Phala or Amalaki), and honey and sugar (Sarkara). Materials and Methods: Methanolic extract of the DKV formulations was used for this study. Methanolic extract of three marketed preparation of DKV also use for the comparative study of DKV. This formulation was known as DKV-1, DKV-2, and DKV-3. A sample of this marketed formulation also used for 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Result and Discussion: The methanolic extract of DKV exhibited a maximum DPPH scavenging activity of 68.24% at 100 µg/ml, and marketed formulations of DKV (DKV-1, DKV-2, and DKV-3) exhibited maximum DPPH scavenging activity 67.90%, 68.35%, and 68.40%, respectively, at 100 µg/ml. With the standard ascorbic acid, it was found to be 84.75% at 100 µg/ml. The IC50 values of the methanolic extract of DKV were 63.27 µg/ ml, and marketed formulations (DKV-1, DKV-2, and DKV-3) were 63.13 µg/ml, 62.82 µg/ml, and 62.91 µg/ml, respectively, and ascorbic acid was 40.05 µg/ml. Conclusion: Results obtained suggest the antioxidant and free radical scavenging activity potential of DKV, and further it may be used as an antioxidant in associated diseases.

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Evaluation of antioxidant and anti-atherogenic properties ofGlycyrrhiza glabraroot usingin vitromodels

Cited by 76 publications

References 31 publications

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

In-vitro studies on antioxidant, anti-melanogenic and anti-wrinkle effects of medicinal plant Glycyrrhiza uralensis

Comparison the Effect of Echium Amoenum Extract With Fluoxetine on Depression in Menopausal Women. A Double-Blind Randomized Controlled Trial

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