Evaluation of antioxidant and anti-inflammatory activity of Euphorbia heyneana Spreng

Battu, Ganga Rao; Ethadi, Sambasiva Rao; Priya, G.; Priya, Khushbu; Chandrika, K; Rao, A. V.; Reddy, Satya Obbala

doi:10.1016/s2221-1691(11)60154-8

Cited by 36 publications

(25 citation statements)

References 18 publications

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“…Therefore, from our present study, we can assume that the anti-inflammatory effect presented by L. javanicum leaves extract may be due to inhibition of COX enzyme induced prostaglandin synthesis. The similar trend was shown by methanolic extract of Euphorbia heyneana Spreng (Battu et al, 2011). On the other hand, formalin induced paw edema (Table 4) bioassay in rat model is best suit to evaluate anti-arthritic and anti-inflammatory agent as it resemble produce localized inflammation and pain similar to human arthritis.…”

Section: Resultssupporting

confidence: 63%

Investigation of Anti-inflammatory and Analgesic Properties of Methanolic Extract of Lophopetalum javanicum Leaves

Ansari¹,

Azamm²,

Hannan³

et al. 2014

J. of Biological Sciences

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A B S T R A C TWe aimed to investigate and evaluate the anti-inflammatory and analgesic effectiveness of common tree in the locality of Bangladesh, Lophopetalum javanicum. Our study includes; the investigation of the phytochemical composition and in-vivo analgesic and anti-inflammatory activity of Methanolic Extract of Lophopetalum javanicum (MELJ). On that point are four methods we applied to investigate the effect, including; Formalin induced paw edema and Carrageenan induced paw edema for anti-inflammatory assay and to access analgesic effect we used the Hot plate method and Tail immersion method. At the dose of 500 mg kgG 1 the extract shows the considerable inhibitory effect on paw increase 1 h after carrageenan administration, by inhibiting over 50%. The maximum inhibition (52.27±0.017%; p<0.0001) elicited by the methanolic extract at 3 h after carrageenan injection. In the assay of hotplate method, L. javanicum increases pain tolerance, time up to 17.83±0.085 min, where the compared standard lengthened response time to 21.68±0.427 min. In tail immersion method the response time was elongated at 600 mg kgG 1 by L. javanicum 4.49±0.214 (p<0.0001) after 2 h of extract induction. This study reflects that the plant is effective in inhibiting pain mediators, thus can be developed as analgesic and anti-inflammatory agent through proper isolation and adjustment.

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Section: Resultssupporting

confidence: 63%

Investigation of Anti-inflammatory and Analgesic Properties of Methanolic Extract of Lophopetalum javanicum Leaves

Ansari¹,

Azamm²,

Hannan³

et al. 2014

J. of Biological Sciences

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“…Inflammation and pain are our body's natural reaction to injury caused by infectious agents, burn, toxic or physical, chemical or traumatic damages (Battu et al, 2011). The reaction comprises systemic and local responses (Mohamed et al, 2011).…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

In Vitro Anti Inflammatory and Anti Microbial Properties of Allophylus Serratus Leaf Extracts.

Jemal¹,

Sandeep²,

Pola³

2017

IJAR

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“…Hydroxyl radical is one of the potent reactive oxygen species in the biological system. It reacts with polyunsaturated fatty acid moieties of cell membrane phospholipids and causes damage to cell 19 . IC 50 values of methanol extract of whole plant of C. pusillus and standard ascorbic acid were 31.22 µg/mL and 43.93µg/mL respectively.…”

Section: Discussionmentioning

confidence: 99%

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2016

IJPSR

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Objective: Present study was aimed to evaluate the total phenolic, flavonoid content and in vitro antioxidant activity of petroleum ether, benzene, ethyl acetate, methanol and ethanol extracts of whole plant of Catharanthus pusillus. Methods: Antioxidant activity have been tested using various antioxidant model systems viz., DPPH, hydroxyl, superoxide, ABTS and reducing power. Results: Methanol extract of Catharanthus pusillus is found to possess higher DPPH, hydroxyl, superoxide radical scavenging activity, while ethyl acetate extract is found to possess higher ABTS radical cation scavenging activity. Methanol extract of whole plant of Catharanthus pusillus shows the highest reducing ability. Conclusion: The study indicates the significant free radical scavenging potential of Catharanthus pusillus whole plant which can be experimented for the treatment of various free radicals mediated aliments.

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Evaluation of antioxidant and anti-inflammatory activity of Euphorbia heyneana Spreng

Cited by 36 publications

References 18 publications

Investigation of Anti-inflammatory and Analgesic Properties of Methanolic Extract of Lophopetalum javanicum Leaves

Investigation of Anti-inflammatory and Analgesic Properties of Methanolic Extract of Lophopetalum javanicum Leaves

In Vitro Anti Inflammatory and Anti Microbial Properties of Allophylus Serratus Leaf Extracts.

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