Evaluation of antioxidant and anticancer properties of the seed extracts of Syzygium fruticosum Roxb. growing in Rajshahi, Bangladesh

Islam, Samia; Nasrin, Shamima; Khan, Muhammad Ali; Hossain, Alamgir; Islam, Farhadul; Khandokhar, Proma; Mollah, Md. Nurul Haque; Rashid, Mamunur; Sadik, Golam; Rahman, Aziz Abdur; Alam, Ahm Khurshid

doi:10.1186/1472-6882-13-142

Cited by 74 publications

(73 citation statements)

References 35 publications

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“…As far as all cellular components, proteins, polyunsaturated fatty acids, nucleic acids, and carbohydrates are prominent biological targets of reactive oxygen species, giving rise to metabolic and cellular disturbances. Foods, rich in antioxidants, should play an essential role in the prevention of many pathologies such as cardiovascular diseases, cancer, and neurodegenerative diseases as well as cell inflammatory problems caused by cutaneous agents (Islam et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

Mokdad-Bzéouich

Kilani-Jaziri

Mustapha

et al. 2015

Pharmaceutical Biology

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Context: The leaves of Eriobotrya japonica (Thunb.) Lindl. (Rosaceae) are used in traditional medicine to treat inflammatory diseases. However, information about the antigenotoxic and antioxidant properties of its leaves remains to be elucidated. Objective: The objective of this work was to evaluate the mutagenic/antimutagenic, genotoxic/ antigenotoxic, and antioxidant potentials of aqueous and total oligomers flavonoid (TOF) extracts from E. japonica. Materials and methods: The mutagenic/antimutagenic and genotoxic/antigenotoxic potentials of extracts (50, 250, and 500 mg/plate) were evaluated, respectively, by the Ames test with 48 h incubation and the SOS chromotest test with 2 h incubation. The antioxidant capacity of these extracts (ranging from 50 to 700 mg/mL) was tested using xanthine/xanthine oxidase and the deoxyribose assays. Results: Eriobotrya japonica extracts showed neither mutagenic nor genotoxic effect. The highest protective effect against methyl methanesulfonate and 2-aminoanthracene was obtained in the presence of aqueous extract, with IC 50 values of 80 and 140 mg/plate, respectively, against S. typhimurium TA104. Moreover, this extract (500 mg/plate) was also able to reduce significantly the genotoxicity induced by nitrofurantoin and aflatoxin B1 with IC 50 values of 140 and 240 mg/assay, respectively. Likewise, aqueous and TOF extracts inhibited xanthine oxidase and superoxide anion formation with IC 50 values ranging from 45 to 95 and from 70 to 90 mg/mL, respectively. However, TOF extract is more efficient in inhibiting hydroxyl radical and chelating iron ion with IC 50 values of 140 and 400 mg/mL, respectively, when compared with the aqueous extract. Conclusion: Eriobotrya japonica prevents the genotoxicity of some carcinogenic substances probably thanks to its antioxidant capacities.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

Mokdad-Bzéouich

Kilani-Jaziri

Mustapha

et al. 2015

Pharmaceutical Biology

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“…Hence, prevention of oxidative damage caused by ROS is an important strategy for the prevention and treatment of cancer. Plants rich in antioxidative polyphenols have been linked to a decreased risk for developing cancer through various mechanisms, including apoptosis [44, 45]. Thus, intensive efforts have been undertaken to search for plant-derived antioxidants and anti-cancer agents that are both effective and safe [45, 46].…”

Section: Discussionmentioning

confidence: 99%

The Antioxidative Fraction of White Mulberry Induces Apoptosis through Regulation of p53 and NFκB in EAC Cells

et al. 2016

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In this study, the antioxidative fraction of white mulberry (Morus alba) was found to have an apotogenic effect on Ehrlich’s ascites carcinoma cell-induced mice (EAC mice) that correlate with upregulated p53 and downregulated NFκB signaling. The antioxidant activities and polyphenolic contents of various mulberry fractions were evaluated by spectrophotometry and the ethyl acetate fraction (EAF) was selected for further analysis. Strikingly, the EAF caused 70.20% tumor growth inhibition with S-phase cell cycle arrest, normalized blood parameters including red/white blood cell counts and suppressed the tumor weight of EAC mice compared with untreated controls. Fluorescence microscopy analysis of EAF-treated EAC cells revealed DNA fragmentation, cell shrinkage, and plasma membrane blebbing. These characteristic morphological features of apoptosis influenced us to further investigate pro- and anti-apoptotic signals in EAF-treated EAC mice. Interestingly, apoptosis correlated with the upregulation of p53 and its target genes PARP-1 and Bax, and also with the down-regulation of NFκB and its target genes Bcl-2 and Bcl-xL. Our results suggest that the tumor- suppressive effect of the antioxidative fraction of white mulberry is likely due to apoptosis mediated by p53 and NFκB signaling.

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“…Previous studies reported that anticancer property of phenolic compounds is due to their antioxidant activity (Islam et al, 2013;Ghasemzadeh and Jaafar, 2013). Natural phenolics have been found to intervene at all stages of cancer development by their antioxidant action (Dai and Mumper 2010).…”

Section: Discussionmentioning

confidence: 99%

Evaluation on Hydnophytum formicarum Tuber from Setiu Wetland (Malaysia) and Muara Rupit (Indonesia) for Antibacterial and Antioxidant activities, and anti-cancer Potency against MCF-7 and HeLa Cells

2017

J App Pharm Sci

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This current study is to evaluate and compare the antibacterial, antioxidant and anticancer activity of H. formicarum tubers from Setiu Wetland, Terengganu, Malaysia and inland forest of Muara Rupit, SumateraSelatan, Indonesia. The tubers were extracted using methanol and then sequentially fractioned using solvent partitioning by n-hexane, dichloromethane, and ethyl acetate. The phytochemical study showed that samples from both places possessed same phytochemicals content that was rich with phenols, tannins, steroids, and glycosides. Extract from Setiu exhibit antibacterial activity against all tested bacteria, while methanol extract from Muara Rupit was only active against Gram positive bacteria. All samples showed high DPPH free radical scavenging activity (IC50 less than 10 µg/ml). Via MTS assay, no cytotoxic activity of all samples was observed against HeLa cells. Only a fraction from Setiu Wetland showed very strong cytotoxic activity against MCF-7 cells (IC50 = 2 µg/ml) and its morphological features stained by Annexin-V/PI and DAPI showed that the cell death was mediated by apoptosis. Results revealed that H. formicarum tuber from Setiu wetland and Muara Rupit showed very good potency as antibacterial and antioxidant agents. The only sample from Setiu wetland has a good potency as anticancer against MCF-7 cells but not against HeLa cells.

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Evaluation of antioxidant and anticancer properties of the seed extracts of Syzygium fruticosum Roxb. growing in Rajshahi, Bangladesh

Cited by 74 publications

References 35 publications

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

The Antioxidative Fraction of White Mulberry Induces Apoptosis through Regulation of p53 and NFκB in EAC Cells

Evaluation on Hydnophytum formicarum Tuber from Setiu Wetland (Malaysia) and Muara Rupit (Indonesia) for Antibacterial and Antioxidant activities, and anti-cancer Potency against MCF-7 and HeLa Cells

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