Evaluation of antioxidant, antiinflammatory, and gastroprotective properties of Rubus fruticosus L. fruit juice

Abstract

The juice of R. fruticosus (RFJ) fruits grown in Sicily was analysed for polyphenol compounds and tested to evaluate in vitro antioxidant and in vivo antiinflammatory and gastroprotective effects. RFJ, containing mainly anthocyanins, such as cyanidin derivatives, significant amounts of phenolic acids, and smaller amounts of flavonoids, showed significant antioxidant activity in DPPH (2,2-diphenyl-1-picrylhydrazyl radical) (4,147.194 ± 17.199 mg trolox equivalent [TE]/100 ml), TE antioxidant capacity (8,312.444 ± 43.055 mg TE/100 ml), ferric reducing antioxidant power (2,177.830 ± 21.015 mg TE/100 ml), oxygen radical absorbance capacity (95,377.674 ± 616.194 μmol TE/100 ml juice), and β-carotene bleaching (72% ± 4.58) assay. In vivo studies showed that RFJ inhibit significantly the carrageenan-induced paw oedema (63-71%) in rats and possess antiinflammatory effects particularly significant in association with phenylbutazone (94-96%). In addition, RFJ pretreatment was able to prevent the ethanol-induced ulcerogenic effect in rats. All in vivo results were corroborated by histopathological observations and are in good agreement with antioxidant activity, confirming the relationships between biological effects observed and radical scavenging properties of RFJ.

Evaluation of Anthocyanin Profile, Antioxidant, Cytoprotective, and Anti-Angiogenic Properties of Callistemon citrinus Flowers

“…Our metabolism and lifestyles, which expose organisms to many different stresses, generate, daily, a remarkable amount of reactive oxygen species (ROS) involved in illness conditions that can bring to the development of pathological states, influencing human wellness. Proanthocyanidins, and even more, anthocyanins, are one of the most promising and strong antioxidants among the flavonoid compounds [25,29,[46][47][48][49][50][51]. This behavior has been confirmed by the data obtained in free radical scavenging assays performed in this study, based on both hydrogen atom transfer and electron transfer-based methods.…”

The Efficacy of Processing Strategies on the Gastroprotective Potentiality ofChenopodium quinoaSeeds

“…Pretreatment of rats with OMP or QP, QG, QB, QF significantly inhibited the overexpression of these inflammatory parameters and attenuated inflammatory responses. e inhibitory activity of the different types of processed red quinoa seeds close to omeprazole efficacy can be referred to the gastroprotective and anti-inflammatory activities of flavonoids, phenolic acids [64,66,67], and carotenoids [72,73] released variably from the processed red seeds [8,9] via blocking the signaling pathway of TNF-α and inhibition of the inflammatory mediators involved (COX-2 and iNOS) [74].…”

Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy

“…Phenolic compounds are bioactive constituents in fruits, grains, and vegetables. It has been proved that these compounds exhibit many bioactivities, including anticancer, antioxidant, anti‐inflammatory, and antimicrobial (Liu et al, ; Mocan et al, ; Monforte et al, ). Particularly, some phenolic compounds have been reported to be multitarget agents interfering with several processes involved in cancer development and progression (Liu et al, ).…”