Evaluation of antioxidant capacity and immunomodulatory effects of yeast hydrolysates for hepatocytes of blunt snout bream (Megalobrama amblycephala)

Yuan, Xiangyang; Liu, Wenbin; Jiang, Guang‐Zhen; Cao, Xiufei; Dai, Yong‐Jun; Wang, Congcong; Desouky, Hesham Eed

doi:10.1016/j.fsi.2020.06.019

Cited by 9 publications

(10 citation statements)

References 49 publications

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“…Consistent with the corresponding activities of antioxidative enzymes, the genes expression of SOD1 and GPX1 were also upregulated. Similarly, supplementing other yeast-derived products could improve the antioxidative enzymes activities, meanwhile, enhancing corresponding genes expression ( El-Murr et al., 2019 ; Rahimnejad et al., 2020 ). We deduced that YC-EHY, as an antioxidant, might improve the antioxidant capacity of broiler chickens by regulating the related genes expression in Nrf2 signaling pathway and thereby enhancing the activities of antioxidant enzymes and reducing the damage of lipid peroxidation.…”

Section: Disscusionmentioning

confidence: 99%

“…Yeast-derived products, such as yeast cell call ( Wang et al., 2017 ; Ma et al., 2020 ), yeast hydrolysate ( Fu et al, 2019 ; Rahimnejad et al., 2020 ), dried yeast extracts ( Kim et al., 2019b ), and yeast culture ( Samarasinghe et al, 2004 ; Sun et al., 2020 ), are natural feed additives that have been used in animals for decades. Supplementing animals with yeast cell wall improved the growth performance, digestive function, and antioxidant capacity of animals ( Li et al., 2016 ; Wang et al., 2017 ; Salinas-Chavira et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of a yeast-derived product on growth performance, antioxidant capacity, and immune function of broilers

Wang

Cheng

et al. 2021

Poultry Science

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Yeast culture plus enzymatically hydrolyzed yeast cell wall ( YC-EHY ) contains crude protein, mannan-oligosaccharide, β-glucan and yeast culture. This study was carried out to explore the effects of dietary YC-EHY at different levels on growth performance, antioxidant capacity, and immune function of broiler chickens. A total of 320 one-day-age male broiler chicks were allocated into 4 groups and were fed with a basal diet supplemented with 0 mg/kg (the control group), 50 mg/kg, 100 mg/kg, 150 mg/kg YC-EHY for 42 d. Dietary YC-EHY improved average daily gain and feed efficiency during the starter, grower, and overall periods as well as average body weight of broiler chickens on 42 d (linear and quadratic, P < 0.05). Broiler chickens fed with YC-EHY quadratically increased jejunal sucrase activity on 21 d (quadratic, P < 0.05), and linearly and quadratically enhanced maltase activity on 21 and 42 d (linear and quadratic, P < 0.05). Supplementing YC-EHY linearly and quadratically enhanced jejunal superoxide dismutase ( SOD ) activity on 21 and 42 d and glutathione peroxidase ( GPX ) activity on 42 d whereas decreased malonaldehyde ( MDA ) concentration on 42 d (linear and quadratic, P < 0.05). Consistently, the jejunal genes expression of nuclear factor erythroid 2-related factor 2 ( Nrf2 ) and SOD1 on 21 and 42 d, heme oxygenase-1 ( HO-1 ) and GPX1 on 42 d were enhanced by YC-EHY supplementation (linear and quadratic, P < 0.05). The concentrations of jejunal immunoglobulin G ( IgG ) on 21 and 42 d and secreted immunoglobulin A ( SIgA ) on 42 d were linearly and quadratically elevated by supplementing YC-EHY (linear and quadratic, P < 0.05). Dietary YC-EHY quadratically increased jejunal IgG and IgM genes expression on 21 d (quadratic, P < 0.05), and linearly and quadratically enhanced the genes expression of IgG and IgM on 42 d (linear and quadratic, P < 0.05). Overall, this study indicated that supplementing YC-EHY could exert beneficial effects on growth performance, intestinal antioxidant capacity and immune function in broiler chickens.

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Section: Disscusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of a yeast-derived product on growth performance, antioxidant capacity, and immune function of broilers

Wang

Cheng

et al. 2021

Poultry Science

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“…The dietary supplementation of antioxidants, such as vitamin E, and others, may improve growth performance and have the function of protecting the cells from ROS (Ghazi Harsini et al., 2012 ) that are naturally generated due to the immune response, or exacerbated in stress situations. Additionally, biofactors as metabolites from a yeast cell hydrolysate showed antioxidant effects in fish hepatocytes by enhancing the activity of superoxide dismutase, catalase, and glutathione peroxidase ( Rahimnejad et al., 2020 ). Moreover, the term postbiotic has been employed to define molecules produced during the metabolic processes of microorganisms, and has been applied to reduce the negative effects of pathogens, such as Clostridium perfringens , in chickens ( Johnson et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

A protected complex of biofactors and antioxidants improved growth performance and modulated the immunometabolic phenotype of broiler chickens undergoing early life stress

Bortoluzzi¹,

Lahaye²,

Perry

et al. 2021

Poultry Science

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We evaluated the supplementation of a protected complex of biofactors and antioxidants [P(BF+AOx)] on growth performance, antioxidant activity, expression of immune-related genes, and immunometabolic phenotype of broilers submitted to early life stressors. The treatments were a nutritionally complete basal diet supplemented or not with P(BF+AOx) (Jefo Nutrition Inc., Saint-Hyacinthe, QC, Canada) from 1 to 14 d of age. 720 one-day old male Ross 308 chickens were placed into pens of 30 birds (12 replicates/treatment). Birds were double-vaccinated against infectious bronchitis ( IB ; MILDVAC-Ma5 T ) at the hatchery and submitted, on d 3, to an acute reduction on environmental temperature (from 32° C to 20°C) for 48 h. Feed intake ( FI ), body weight gain ( BWG ), and feed conversion ratio ( FCR ) were calculated weekly. On d 7 and 15, samples were collected for expression of immune-related genes and kinome array analysis, and serum to evaluate the antioxidant status. Data were analyzed by ANOVA using SAS (SAS 9.4). From d 1 to 21 and d 1 to 28, the dietary supplementation of P(BF+AOx) significantly increased BWG ( P < 0.05) by 3.6 and 3.8%, respectively, and improved FCR ( P < 0.05) by 1.2 and 1.8%, respectively. From d 1 to 35, dietary supplementation enhanced BWG ( P = 0.03) by 4%. Serum glutathione reductase activity on d 15 was higher in birds fed diets supplemented with P(BF+AOx) compared to the control diet-fed birds ( P = 0.04). Dietary supplementation reduced the expression of IL-1β ( P = 0.03) in the lungs on d 7. On d 15, dietary supplementation increased the expression of IL-6 ( P = 0.02) and IL-10 ( P = 0.03) in the liver. It was observed that, via decreased phosphorylation, catalase was activated in the jejunum and liver, and the phosphorylation of immunoregulatory or proinflammatory proteins was decreased. Other important cellular signaling pathways were also changed in the liver and jejunum due to the supplementation. The supplementation of P(BF+AOx) improves growth performance by promoting a general anti-inflammatory and antioxidant response in chickens undergoing early life stress.

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“…13,14 Moreover, relevant research studies on aquatic animals have indicated that fish fed with yeast hydrolysate showed enhanced activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT), but decreased concentration of malonaldehyde (MDA) in the liver. 5,10 Park et al 15 indicated that yeast hydrolysate (YH) improved egg production and quality as well as nutrient digestibility of laying hens, and Fu et al 16 showed that YH enhanced antioxidant capacity in serum as well as the counts of beneficial bacteria in cecum of growingfinishing pigs.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, research on ruminants and rodents has demonstrated that the addition of live yeast or polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae in the diet decreased low‐density lipoprotein cholesterol (LDL‐C), total cholesterol (TC) and blood urea nitrogen in serum, thus regulating serum metabolism in the body 13,14 . Moreover, relevant research studies on aquatic animals have indicated that fish fed with yeast hydrolysate showed enhanced activities of superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px) and catalase (CAT), but decreased concentration of malonaldehyde (MDA) in the liver 5,10 . Park et al 15 .…”

Section: Introductionmentioning

confidence: 99%

Effects of yeast hydrolysate on growth performance, serum parameters, carcass traits, meat quality and antioxidant status of broiler chickens

Wang

Cheng

et al. 2021

J Sci Food Agric

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BACKGROUND Yeast hydrolysate (YH) has multiple salutary biological activities. Nevertheless, the application of YH in broiler production is limited. This study was conducted to evaluate the protective effects of YH derived from Saccharomyces cerevisiae by exploring growth performance, serum parameters, organs relative weight, carcass traits, meat quality and antioxidant status of broilers. RESULTS Supplementing YH linearly and quadratically improved (P < 0.05) body weight gain and gain‐to‐feed ratio compared to that in the control group. Triglycerides, low‐density lipoprotein cholesterol and total cholesterol in serum, the decline in pH and cooking loss of breast muscle, and malonaldehyde concentration in serum and liver were decreased linearly and/or quadratically by YH (P < 0.05), whereas high‐density lipoprotein cholesterol in serum, superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) activities in serum, GSH‐Px activity in liver, glutathione content in serum and liver, eviscerated yield rate and chest muscle yield, and the relative weight of spleen and liver were linearly and/or quadratically increased (P < 0.05). Moreover, YH enhanced the mRNA levels of nuclear factor erythroid 2‐related factor 2, heme oxygennase‐1 (HO‐1), GSH‐Px1 and SOD1 (linear and/or quadratic, P < 0.05). CONCLUSION Dietary YH beneficially affected growth performance, serum parameters, organ relative weight, carcass traits, meat quality and antioxidant status in broilers, indicating its potential application as a promising feed additive in broiler production. © 2021 Society of Chemical Industry.

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Evaluation of antioxidant capacity and immunomodulatory effects of yeast hydrolysates for hepatocytes of blunt snout bream (Megalobrama amblycephala)

Cited by 9 publications

References 49 publications

Effects of a yeast-derived product on growth performance, antioxidant capacity, and immune function of broilers

Effects of a yeast-derived product on growth performance, antioxidant capacity, and immune function of broilers

A protected complex of biofactors and antioxidants improved growth performance and modulated the immunometabolic phenotype of broiler chickens undergoing early life stress

Effects of yeast hydrolysate on growth performance, serum parameters, carcass traits, meat quality and antioxidant status of broiler chickens

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