Evaluation of antioxidant effect of Nerium indicum in anxious rats

Mohale, D.S.; Tripathi, Alok Shiomurti; Shrirao, Abhijit V.; Jawarkar, Amol G; Chandewar, A. V.

doi:10.4103/0253-7613.186201

Cited by 9 publications

(10 citation statements)

References 17 publications

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“…Methanol extract of N. indicum lowers are more potent anti-oxidant than leaves (Vinayagam and Sudha, 2011). Mohale et al (2016) reported the antioxidant activity of ethyl acetate extract of N. indicum lowers. According to them treatment with this extract caused signi icant increase in the endogenous antioxidants, superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) in blood and brain of rats (Mohale et al, 2016).…”

Section: Anti-oxidant Propertiesmentioning

confidence: 99%

“…Mohale et al (2016) reported the antioxidant activity of ethyl acetate extract of N. indicum lowers. According to them treatment with this extract caused signi icant increase in the endogenous antioxidants, superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) in blood and brain of rats (Mohale et al, 2016). Several plant based products contain tremendous ROS scavenging capacity (Dey and Chaudhari, 2014).…”

Section: Anti-oxidant Propertiesmentioning

confidence: 99%

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Nerium indicum(Linn.): A potential phytomedicine against various health problems

Singh

Kumar²,

Kumar

et al. 2020

ijrps

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Nerium indicum (Linn Apocyanaceae family) is wild plant and commonly known as “Kaner”. It is used against various health problems in India and China as ethno medicine. India and China is among the oldest civilizations on earth. Ethno medicines are developed in ancient time by experiences sharing with nature. Aim of the present study is to explore the ancient knowledge of phytomedicine in context of modern science. Vedic period is the oldest cultural representation of human civilization. Ayurvedic system of medicine was developed in ‘Susruta Samhita’ and ‘Charak Samhita’. Nerium indicum (Linn.) is one of the thousands of plants mentioned in Ayurvedic system of India as important medicine for the treatment of various ailments. The flowers and leaves of N. indicum have been used to stimulate cardiac muscle, relieve pain and eliminate blood stasis. Present review mainly deals with the phytomedicinal properties such as analgesic, anti-diabetic, anti-oxidant, anti-bacterial, anti-viral, insecticidal/molluscicidal, hepatoprotective, neuroprotective, anti-cancer, anti-hyperlipidemic, anti-feedent activity of N. indicum. Its role as bioindicator in predicting the environmental condition is also discussed. N. indicum contains glycoside, oleandrin, tannin, volatile oil 0.25%. Glucoside, neriin and oleandrin are found in leaves of this plant. Nerium indicum is one of the wild plants, which is commonly used in various cultures as ethnic medicine. Although recent researches on its medicinal properties had established its therapeutic value in treatment of ailments, yet lot of studies are still required to explain its potentials as safe phytomedicine.

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Section: Anti-oxidant Propertiesmentioning

confidence: 99%

Section: Anti-oxidant Propertiesmentioning

confidence: 99%

Nerium indicum(Linn.): A potential phytomedicine against various health problems

Singh

Kumar²,

Kumar

et al. 2020

ijrps

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“…Psychiatric disorders like anxiety or depression were also proved to be connected with neurodegenerative disturbances as well as changes of immunological and oxidative parameters which were alleviated by plant extracts [ 111 , 112 ].…”

Section: The Protective Properties Of Plant Preparations Against Tmentioning

confidence: 99%

The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?

Kiełczykowska

Musik

2020

Oxidative Medicine and Cellular Longevity

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The application of chemicals in industry and agriculture has contributed to environmental pollution and exposure of living organisms to harmful factors. The development of new pharmaceutical agents enabled successful therapy of various diseases, but their administration may be connected with side effects. Oxidative stress has been found to be involved into etiology of numerous diseases as well as harmful action of drugs and chemicals. For some time, plant origin substances have been studied as potential protective agents alleviating toxicity of various substances and symptoms of diseases. The aim of the current review was to present the diversity of the research performed during the last five years on animal models. The outcomes showed a huge protective potential inherent in plant preparations, including alleviating prooxidative processes, strengthening antioxidant defence, ameliorating immune parameters, and reversing histopathological changes. In many cases, plant origin substances were proved to be comparable or even better than standard drugs. Such findings let us suggest that in the future the plant preparations could make adjuvants or a replacement for pharmaceutical agents. However, the detailed research regarding dose and way of administration as well as the per se effects needs to be performed. In many studies, the last issue was not studied, and in some cases, the deleterious effects have been observed.

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“…It has been generally accepted that the inhibition of Cox mediates the anti-in ammatory, antipyretic and analgesic effects of NSAIDs (3), where analgesia has been associated with selective Cox-2 inhibition.…”

Section: Introductionmentioning

confidence: 99%

The effective interplay of (non-) selective NSAIDs with Neostigmine in animal models of analgesia and inflammation

Gowayed

Abdel-Bary

El-Tahan

2020

Preprint

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Background Surgical procedures cause perioperative immunosuppression and neuroendocrine stress, exerted by activation of the autonomic nervous system and the hypothalamic-pituitary-adrenal axis. The acetylcholinesterase inhibitor (ACHEI); neostigmine, is known clinically for its analgesic effect in the perioperative phases proving high efficacy; besides possessing anti-inflammatory properties controlling immune cells and cytokine level. Hence, this study evaluated and compared the analgesic and anti-inflammatory activities of the combination of selective Cox-2 inhibitor; celecoxib, with neostigmine versus a combination of the non-selective Cox inhibitor; diclofenac, with neostigmine; in different experimental models of analgesia and inflammation in rats. Methods Analgesic activity of neostigmine with/without diclofenac or celecoxib was assessed in female Sprague-Dawely rats using the tail clip model and acetic acid induced writhing. Serum level of β-endorphin was assessed after the tail clip test. The anti-inflammatory activity was evaluated using acute and sub-chronic formalin induced paw edema. At the end of the sub-chronic formalin test, blood samples were collected for analysis of anti-inflammatory, liver and kidney function markers. Livers, kidneys and hind paws were also examined histopathologically. Results Addition of neostigmine to selective or non-selective NSAIDs (celecoxib or diclofenac) causes an increased level of analgesia of NSAIDs with rapid onset of action and short duration, while causing potentiation of the anti-inflammatory effect of neostigmine as seen in the tail clip, writhing, formalin test, Cox-1 and Cox-2 activities, serum β-endorphin, TNF-α, NF-кB and HS-CRP. All combinations of this study disturb some kidney and liver functions, however with normal histopathological appearances, while hind paws reveal improved inflammatory infiltration in all treated groups. Conclusion : Selective and non-selective NSAIDs examined in this study could be good adjunct options to general anesthetic agents and neostigmine in perioperative stages, an outcome that needs further clinical investigation.

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Evaluation of antioxidant effect of Nerium indicum in anxious rats

Cited by 9 publications

References 17 publications

Nerium indicum(Linn.): A potential phytomedicine against various health problems

Nerium indicum(Linn.): A potential phytomedicine against various health problems

The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?

The effective interplay of (non-) selective NSAIDs with Neostigmine in animal models of analgesia and inflammation

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