“…In this regard, some in vitro studies [ 22 ] and animal studies [ 23 , 24 ] have been performed and have demonstrated the beneficial effects of melatonin. In human studies, melatonin has been used either in the topical formulation (TF) or systemic formulation (SF) as a monotherapy or adjunctive therapy following SRP [ 6 , 7 , 8 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. However, no systematic review and meta-analysis has critically appraised the use of melatonin in periodontitis.…”