2020
DOI: 10.18203/2319-2003.ijbcp20200542
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Evaluation of antioxidant potential of melatonin in periodontitis with a focus on vitamin C

Abstract: Background: The present study was done with an objective to evaluate the effect of melatonin as an antioxidant, with a focus on vitamin C, in patients suffering from periodontitis.Methods: This study was conducted jointly in the Department of Periodontics, Rural Dental College, and Department of Pharmacology, PIMS, Loni. Patients suffering from chronic periodontitis, of age between 18 to 65 years of either gender were included in the study, after obtaining a written informed consent. Patients were divided into… Show more

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Cited by 3 publications
(22 citation statements)
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“…This was in line with previous studies which observed that the considerable oxidative stress in periodontitis patients was significantly reduced by melatonin administration and declared that not only melatonin but also several endogenously generated metabolites of melatonin function as free radical scavenger [ 5 ]. Similarly, melatonin application was reported to protect the periodontal tissues against ROS injury resulting from inflammatory reactions by reducing the elevated oxidative stress levels in these patients and that it may reduce alveolar bone loss [ 26 ].…”
Section: Discussionsupporting
confidence: 92%
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“…This was in line with previous studies which observed that the considerable oxidative stress in periodontitis patients was significantly reduced by melatonin administration and declared that not only melatonin but also several endogenously generated metabolites of melatonin function as free radical scavenger [ 5 ]. Similarly, melatonin application was reported to protect the periodontal tissues against ROS injury resulting from inflammatory reactions by reducing the elevated oxidative stress levels in these patients and that it may reduce alveolar bone loss [ 26 ].…”
Section: Discussionsupporting
confidence: 92%
“…When endogenous antioxidants are unable to lessen the damaging effects of ROS efficiently, tissue damage can result. The host capability to scavenge ROS is considered as a vital defensive mechanism to counteract the ROS-related periodontal tissue damage [ 5 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Of the included studies, 4 were from Spain, 3 were from India, 3 were from Iran, and 1 each from Italy and Egypt. Six studies were clinical interventions without randomization, two were clinical interventional studies [ 6 , 25 ], two were clinical trials [ 8 , 26 ], and two were prospective longitudinal studies [ 30 , 32 ]. The other six studies were RCTs.…”
Section: Resultsmentioning
confidence: 99%
“…In this regard, some in vitro studies [ 22 ] and animal studies [ 23 , 24 ] have been performed and have demonstrated the beneficial effects of melatonin. In human studies, melatonin has been used either in the topical formulation (TF) or systemic formulation (SF) as a monotherapy or adjunctive therapy following SRP [ 6 , 7 , 8 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. However, no systematic review and meta-analysis has critically appraised the use of melatonin in periodontitis.…”
Section: Introductionmentioning
confidence: 99%