Evaluation of Antioxidant Potentiality of Methanolic and Aqueous Extracts of Pandanus foetidus R. Leaves

Nurunnahar,; Haque, Md. Uzzal; Zahan, Ronok; Islam, Md. Badrul; Mosaddik, Ashik

doi:10.9734/jocamr/2017/34109

Cited by 1 publication

(5 citation statements)

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“…According to earlier research, the methanol extract of Pandanus foetidus has IC50 values of 115.60 μg/ml that showed moderately effective against DPPH free radical scavenging action, while the IC50 value of petroleum ether extract, ethyl acetate extract and methanolic extract of Alangium salvifolium was found to be 94.78 μg/ml, 85.78 μg/ml and 49.23 μg/ml, respectively that is similar to the results of our experiment (Nurunnahar et al, 2017, Bhosale & Singh, 2020. Total phenolic content of the extracts was determined from the standard curve of gallic acid.…”

Section: Hole Cross Testsupporting

confidence: 90%

“…Though the earlier research results differ from our findings, all these studies confirm the presence of antioxidant property in both these plants because of their high phenolic content (Aovi & Rahman, 2019, Shravya et al, 2017 and the presence of phenols and flavonoids was linked to the bioactivity of several plants from the genera of Pandanus and Alangium salvifolium (Nurunnahar et al, 2017, Shravya et al, 2017, Jain & Jain, 2011. The acetic acid-induced writhing test is highly recommended due to its sensitivity and ability to detect antinociceptive effects of natural products, in which the abdominal constriction was associated with the identification of peripheral analgesic activity of the extracts (Subedi et al, 2016).…”

Section: Hole Cross Testcontrasting

confidence: 46%

“…The phenolic compounds found in plants have strong antioxidant capabilities (Dehshahri et al, 2012). At 100μg/ml concentration, the phenolic content was found to be 33.33 ± 5.06 mg/g in combined extract whereas 45.75±5.69 mg/g and 152.73 ± 13.60 mg/g of gallic acid were found in Pandanus foetidus and Alangium salvifolium, respectively (Nurunnahar et al, 2017, Zahan et al, 2013 which contributed to the antioxidant property of these plant extracts.…”

Section: Hole Cross Testmentioning

confidence: 95%

“…Numerous antibacterial, antiviral, anti-inflammatory, anti-cancer, and anti-allergic effects have been observed in studies on flavonoid derivatives (Montoro et al, 2005). A previous study suggested that the methanol extracts of Pandanus foetidus has flavonoid content of 295.27 ±6.29 mg/g of catechin, whereas the concentration of flavonoids found in Alangium salvifolium were 59.26 mg/gm of catechin (Nurunnahar et al, 2017, Patel & Manigauha, 2018.…”

Section: Hole Cross Testmentioning

confidence: 96%

“…Leaf part of this medicinal plant exhibited antinociceptive, antiinflammatory, analgesic, antidiarrheal, cytotoxic, CNS depressant and thrombolytic activities to heal a number of diseases (Lokman et al, 2013, Islam et al, 2013, Rahman et al, 2015, Hossen et al, 2014. The plant P. foetidus possesses significant bioactive principles (Sikder et al, 2013) and phytochemical screening of the plant indicated to the presence of carbohydrates, saponins, tannins, glycosides, steroids, alkaloids, polyphenol and flavonoids that are responsible for the antioxidant activity of this plant species (Lokman et al, 2013, Nurunnahar et al, 2017.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, analgesic, anti-inflammatory and CNS depressant activities of ethanolic and combined extracts of Pandanus foetidus and Alangium salvifolium: In vitro and In vivo studies

2023

Int. J. Biosci.

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The present study investigated the phytochemical, antioxidant and in vivo biological activities such as anti-inflammatory, analgesic and CNS depressant activities of the ethanolic extracts of Pandanus foetidus (leaves), Alangium salvifolium (leaves and flowers) and combined extract of these plant species. In the DPPH radical scavenging activity assay, IC50 value of 28.5 µg/ml was found for the combined extract whereas the total antioxidant capacity (0.94±0.3) of that extract was concentrationdependent. All the extracts contained polyphenols and flavonoids but higher values of total phenolic (33.33 ± 5.06 mg/g) and total flavonoid (318.4 ± 4.39 mg/g) content were determined for the combined extract. The combined extract showed higher writhing inhibition (81%; 100mg/Kg body weight) among all the extracts which is quite comparable to the standard drug diclofenac sodium (87.17%; 10mg/Kg body weight). Anti-inflammatory activity of all the extracts was found to be moderate, but the combined extract showed higher activity (87.5% at 100 mg/kg body weight) in mice when compared to the standard (91.25% at 10 mg/kg body weight). The CNS depressant activity of combined extract was 39.75±2.63 at 90 min after administration of the extract, which was 28.25±1.46 for the standard. Our findings suggested that the combined extract of these species can be used as an herbal remedy in pain, inflammatory and CNS disorders. This is the first time that phytochemical and pharmacological activities of combination of extracts of these plant species have been reported.

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Section: Hole Cross Testsupporting

confidence: 90%