Evaluation of antioxidant status and oxidative stress in sheep naturally infected with Babesia ovis

Esmaeilnejad, Bijan; Tavassoli, Mousa; Asri‐Rezaei, Siamak; Dalir‐Naghadeh, Bahram

doi:10.1016/j.vetpar.2011.10.001

Cited by 46 publications

(32 citation statements)

References 34 publications

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“…These results agree with those reported earlier in sheep suffering from babesiosis [34, 53], in cattle suffering from theileria [31, 54] and in people suffering from malaria [24, 55, 56]. However, Chaudhuri et al [38] found significantly increased SOD and catalase activity in dogs infected with B. gibsoni .…”

Section: Discussionsupporting

confidence: 91%

“…Since there was just one severely anaemic dog, it was impossible to fully complete the comparison of anaemia with the investigated biomarkers, but it could be postulated that changes in severely anaemic dogs would be more prominent than those in moderately and mildly anaemic dogs. These results agree with those obtained in sheep with babesiosis and cattle suffering from theileriosis [31, 34, 53]. …”

Section: Discussionsupporting

confidence: 91%

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Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis

et al. 2017

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BackgroundCanine babesiosis is caused by species of the Babesia genus and has become an emerging disease worldwide. To the authors’ knowledge there are no reports in which antioxidants have been analyzed in different presentations of canine babesiosis or in which the prognostic value of antioxidants has been studied. The aim of this study was to evaluate whether oxidative stress could be related to the severity and outcome of canine babesiosis. For this purpose a profile consisting of four antioxidant biomarkers (superoxide dismutase - SOD, glutathione peroxidase - GPx, catalase, total antioxidant status - TAS) and malondialdehyde - MDA as an oxidant biomarker (previously evaluated, here studied for comparative purposes) were evaluated in dogs with canine babesiosis of different clinical severity and outcomes.ResultsThe study was conducted with a sample of 40 dogs suffering from babesiosis (further divided into uncomplicated, one complication and multiple organ dysfunction syndrome - MODS group) and 30 healthy dogs (control group). Additionally, the babesiosis group was divided according to the anaemia into non-anaemic, mildly anaemic, moderately anaemic and severely anaemic dogs. The results of our study showed significantly decreased SOD, catalase and TAS values in diseased dogs compared to controls, while there were no significant differences in GPx between these groups. Dogs that developed MODS showed lower activities of SOD and GPx and higher MDA values compared to dogs with uncomplicated babesiosis as well as with dogs that developed one complication. Superoxide dismutase, catalase and GPx were negatively correlated whereas MDA was positively correlated with the lethal outcome of the disease. Furthermore, this study detected more pronounced decrease in antioxidant biomarkers (SOD, GPx and catalase) in dogs with moderate anaemia compared to those with mild anaemia.ConclusionsThe results of this study showed changes in biomarkers related to the antioxidant status of dogs naturally infected with B. canis canis. These biomarkers could be used as indicators of disease severity and outcome in dogs suffering from babesiosis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-017-1020-9) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis

et al. 2017

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“…Several studies demonstrated diminishing of antioxidant enzymes (SOD, CAT, GSH-Px, TAC) in hemoprotozoan diseases in domestic animals 14,30 which is in accordance with our study except for SOD activity. Chaudhuri et al 6 reported a significant elevation of CAT and SOD in canine babesiosis compared with non-babesiosis dogs, which is also in contrast to the results presented here.…”

Section: Discussionsupporting

confidence: 92%

“…Several studies have indicated RASOULI, ZAMANI the importance of lipid peroxidation in blood parasitic diseases 6,8,10 . Various others have reported babesiosisinduced MDA elevation in domestic animals such as, sheep naturally infected with Babesia ovis 14 . The same authors demonstrated the important role of B. ovis in the induction of oxidative damage to RBCs and anemia.…”

Section: Discussionmentioning

confidence: 97%

“…The measurement of MDA levels can be used to indirectly measure the degree of lipid peroxidation and the levels of free radicals 6,9,10 . Literature regarding MDA is scarce but includes reports on elevated MDA levels in sheep naturally infected with Babesia ovis and cattle infected with B. bovis 9,14 . The thyroid gland plays a vital role in several functions, such as, oxygen consumption by cells, energy utilization, biologic processes (metabolism, growth and nervous improvement) and the productive performance of domestic animals (hair, milk, fiber).…”

Section: Introductionmentioning

confidence: 99%

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Babesiosisli Koyunlarda Plazma Malondialdehid, Tiroid Hormonları ve Bazı Kan Profilleri

Azimzadeh¹,

Nouri²,

Farooghi³

et al. 2013

Kafkas Univ Vet Fak Derg

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Lipid peroxidation and decrease on the activities of antioxidant enzymes in experimental infection by Babesia bovis in cattle

et al. 2015

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Evaluation of antioxidant status and oxidative stress in sheep naturally infected with Babesia ovis

Cited by 46 publications

References 34 publications

Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis

Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis

Babesiosisli Koyunlarda Plazma Malondialdehid, Tiroid Hormonları ve Bazı Kan Profilleri

Lipid peroxidation and decrease on the activities of antioxidant enzymes in experimental infection by Babesia bovis in cattle

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