Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation

Jain, Mandipika; Parmar, Hamendra Singh

doi:10.1007/s00011-010-0295-0

Cited by 132 publications

(92 citation statements)

References 37 publications

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“…This finding is in agreement with the observation suggesting an increase in exudates and tissue LPO partly mediated via the increase in ROS/RNS radical production in carrageenan-injected animals [41,42]. Pretreatment with MEOg reversed the TBARs levels significantly.…”

Section: Discussionsupporting

confidence: 93%

Ocimum gratissimum Linn. Leaf extract inhibits free radical generation and suppressed inflammation in carrageenan-induced inflammation models in rats

Ajayi

Ologe

Ben‐Azu

et al. 2017

Journal of Basic and Clinical Physiology and Pharmacology

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Background: Ocimum gratissimum leaf is used in managing rheumatism and other inflammatory conditions. In this study, we investigated the antioxidant and anti-inflammatory effects of phenolic extract obtained by sequential methanol extraction of O. gratissimum leaves (MEOg). Methods: The methanol extract (MEOg) was obtained after sequential maceration (n-hexane, chloroform and methanol) of dried O. gratissimum leaves. The fingerprint of the extract was obtained using a high-performance liquid chromatrographic method. In vitro effects were tested by 1,1-Diphenyl-2-picryl-hydrazyl (DPPH), nitric oxide (NO) free radical scavenging, lipoxygenase, and xanthine oxidase inhibitory assays. MEOg was studied for anti-inflammatory activity in carrageenan-induced paw edema and air pouch inflammation in rats. Results: HPLC fingerprint of the extract shows the presence of caffeic acid, rutin, ferulic acid, apigenin, and quercetin.

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Section: Discussionsupporting

confidence: 93%

Ocimum gratissimum Linn. Leaf extract inhibits free radical generation and suppressed inflammation in carrageenan-induced inflammation models in rats

Ajayi

Ologe

Ben‐Azu

et al. 2017

Journal of Basic and Clinical Physiology and Pharmacology

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“…In order to run simulation of the naringin in various compositions of the cosolvent mixture, the one naringin molecule was placed in the center of a cubic box with volume of 24.24 nm 3 . The details of the chosen solvent mixtures are given in Table 9.…”

Section: View Article Onlinementioning

confidence: 99%

Solubility temperature and solvent dependence and preferential solvation of citrus flavonoid naringin in aqueous DMSO mixtures: an experimental and molecular dynamics simulation study

et al. 2017

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This study describes the thermodynamics of dissolution of flavonoid naringin in different aqueous solutions of dimethyl sulfoxide (DMSO) containing 0-100% (w/w) under atmospheric pressure and over a temperature range of 298.15 to 325.15 K. The temperature dependence of solubility of naringin was analyzed using the modified Apelblat equation model, ideal model, and the lH equation model. In a mean harmonic temperature, the dissolution thermodynamic parameters of naringin containing DG sol , DH sol and DS sol were also calculated. Furthermore, the effects of solvent composition on the solubility of this flavonoid were analyzed in terms of Hildebrand's solubility parameter (d H ) and Kamlet, Abboud and Taft (KAT) solvatochromic parameters (a, b, and p*). Finally, the preferential solvation parameters of the flavonoid naringin by DMSO (dx DMSO,S ) were determined from experimental solubility data using the inverse Kirkwood-Buff integrals (IKBIs). It was found that water preferentially solvates naringin in waterrich mixtures while DMSO forms local solvation shells in compositions from 50% (w/w) or x DMSO ¼ 0.19 up to pure co-solvent. Moreover, the structure of solvation shells of naringin in the under study mixtures was obtained by molecular dynamics (MD) simulations. The computational results showed that in the compositions x DMSO > 0.20, the probability of presence of the DMSO molecules in vicinity of naringin is more than water molecules. These findings are compatible with the available IKBI data.

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“…NRG is recognized by more and more people due to its comprehensive physiological and pharmacological effects, including antioxidant (Jung et al 2003, Jeon et al 2004, Rajadurai & Prince 2007, Bodas et al 2011, Jain & Parmar 2011, Mahmoud et al 2012, antihypercholesterolemic (Jung et al 2003, Kim et al 2004, Jung et al 2006, anti-inflammatory (Jung et al 2003, Bodas et al 2011, Mahmoud et al 2012, cardioprotection (Huang et al 2013, Chen et al 2014a and anti-apoptotic effects (Jagetia et al 2003, Kanno et al 2003. Furthermore, Huang et al (2013) and Chen et al (2014a,b) demonstrated that NRG inhibited the MAPK pathway (p38 MAPK, ERK1/2 and JNK) in HG-induced injuries in H9c2 cardiac cells.…”

Section: Introductionmentioning

confidence: 99%

Naringin protects cardiomyocytes against hyperglycemia-induced injuries in vitro and in vivo

Qin

et al. 2016

Journal of Endocrinology

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We previously reported that naringin (NRG) protects cardiomyocytes against high glucose (HG)-induced injuries by inhibiting the MAPK pathway. The aim of this study was to test the hypothesis that NRG prevents cardiomyocytes from hyperglycemia-induced insult through the inhibition of the nuclear factor kappa B (NF-κB) pathway and the upregulation of ATP-sensitive K + (K ATP ) channels. Our results showed that exposure of cardiomyocytes to HG for 24 h markedly induced injuries, as evidenced by a decrease in cell viability and oxidative stress, and increases in apoptotic cells as well as the dissipation of mitochondrial membrane potential (MMP). These injuries were markedly attenuated by the pretreatment of cells with either NRG or pyrrolidine dithiocarbamate (PDTC) before exposure to HG. Furthermore, in streptozotocin (STZ)-induced diabetic rats and in HG-induced cardiomyocytes, the expression levels of caspase-3, bax and phosphorylated (p)-NF-κB p65 were increased. The increased protein levels were ameliorated by pretreatment with both NRG and PDTC. However, the expression levels of bcl-2 and K ATP and superoxide dismutase (SOD) activity were decreased by hyperglycemia; the expression level of Nox4 and the ADP/ATP ratio were increased by hyperglycemia. These hyperglycemia-induced indexes were inhibited by the pretreatment of cardiomyocytes with NRG or PDTC. In addition, in STZ-induced diabetic rats, we also observed that NRG or PDTC contributed to protecting mitochondrial injury and myocardium damage. This study demonstrated that NRG protects cardiomyocytes against hyperglycemia-induced injury by upregulating K ATP channels in vitro and inhibiting the NF-κB pathway in vivo and in vitro.

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Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation

Abstract: It seems that both naringin and hesperidin are anti-inflammatory and antioxidative in nature, but hesperidin proved to be better than indomethacin and naringin because of more pronounced pharmacological actions without tissue toxicity.

Cited by 132 publications

References 37 publications

Ocimum gratissimum Linn. Leaf extract inhibits free radical generation and suppressed inflammation in carrageenan-induced inflammation models in rats

Ocimum gratissimum Linn. Leaf extract inhibits free radical generation and suppressed inflammation in carrageenan-induced inflammation models in rats

Solubility temperature and solvent dependence and preferential solvation of citrus flavonoid naringin in aqueous DMSO mixtures: an experimental and molecular dynamics simulation study

Naringin protects cardiomyocytes against hyperglycemia-induced injuries in vitro and in vivo

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