Evaluation of antiparasitary, cytotoxic and antioxidant activity and chemical analysis of Tarenaya spinosa (Jacq.) Raf. (Cleomaceae)

Bezerra, José Weverton Almeida; Coronel, Cathia; Gómez, María Celeste Vega; Rolón, Míriam; Núñez, Cecília Veronica; Silva, D.R. da; Silva, L.A. da; Rodrigues, Felicidade Caroline; Boligon, Aline Augusti; Souza, Mikael Amaro de; Linhares, Karina Vieiralves; Silva, M.A.P. da; Morais-Braga, Maria Flaviana Bezerra

doi:10.1016/j.sajb.2019.05.025

Cited by 15 publications

(5 citation statements)

References 39 publications

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“…This class of bioactive compound has been shown to exhibit, for example, antioxidant, antidiabetic, antiinflammatory, antiallergic, antiviral, anticancer and antimicrobial activities [41,42]. In the species of the genus Tarenaya, promising antioxidant activity results were found by Bezerra et al [43], its activity justified by the presence of phenolic compounds present in the aqueous and ethanolic extracts of T. spinosa leaves. In another study, carried out by Silva et al [38], organic extracts of stems and roots were evaluated, and their antimicrobial activity justified by some metabolites, including flavonoids, a specific class of phenolic compounds that have already been strongly indicated to have antimicrobial activity.…”

Section: Discussionmentioning

confidence: 99%

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Biological potentialities and chemical composition of Tarenaya aculeata roots and stems

Ferreira Duarte,

Aguayo De Castro,

Sobrinho Ventura

et al. 2023

Rev. Colomb. Quim.

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Plant extracts are rich in secondary metabolites responsible for numerous biological activities. This study aimed to evaluate the antioxidant, antibacterial and photoprotective potentials, toxicity and chemical composition of extracts and fractions of stems and roots of Tarenaya aculeata. Phytochemical analyses were performed at qualitative and quantitative levels to evaluate the classes of secondary metabolites. The sun protection factor (SPF) and antioxidant potentials were determined spectrophotometrically, the antibacterial activity was tested against seven bacteria and the toxicity was evaluated using Artemia salina assay. Phytochemical screening revealed the presence of alkaloids, phenolic compounds, flavonoids, glycosides, tannins and saponins. The levels of phenolic compounds, tannins and alkaloids, SPF and antioxidant potentials showed greater results in the stem (SF) and root (RF) fractions in relation to the stem (SE) and root (RE) extracts. All samples exhibited a broad spectrum of antibacterial activity, with MIC values ranging from 31.25 to 250 μg mL-1. SE, SF and RF caused mortality in A. salina larvae, with LC50 of 347.06, 34.71 and 85.39 μg mL-1, respectively, whereas RE was non-toxic. Thus, T. aculeata is rich in bioactive secondary metabolites, although further studies will be needed to characterize its chemical constituents and investigate their adverse effects.

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Section: Discussionmentioning

confidence: 99%

“…Antioxidant activity has already been observed for Tarenaya species. Bezerra et al [43] evaluated the antioxidant activity of aqueous and ethanolic extracts of T. spinosa leaves, with IC 50 of 377.7 and 445.8 μg mL -1 (Table 4), respectively and attributed this property to the phenolic compounds present in the extracts.…”

Section: Discussionmentioning

confidence: 99%

Biological potentialities and chemical composition of Tarenaya aculeata roots and stems

Ferreira Duarte,

Aguayo De Castro,

Sobrinho Ventura

et al. 2023

Rev. Colomb. Quim.

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“…In recent years, natural products have gained prominence for their therapeutic potential in the treatment of parasitic infections, such as those caused by bacteria, fungi, and protozoa. Since the rapid emergence of resistant strains has increasingly limited the effectiveness of conventional drugs, the identification of secondary metabolites of plants may represent an important alternative in the management of infections by resistant microorganisms [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth

et al. 2021

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Croton heliotropiifolius Kunth (Euphorbiaceae), whose occurrence has already been registered in the most varied Brazilian biomes, is commonly found in the Chapada do Araripe, Ceará. The species is traditionally used to treat fungal, parasitic, and degenerative diseases. This study investigated the chemical composition and pharmacological potential (antioxidant, antifungal, antiparasitic, and cytotoxic) of an aqueous extract obtained from the roots of C. heliotropiifolius. Following a qualitative phytochemical screening, the chemical constituents were identified by ultra-efficiency liquid chromatography coupled witha quadrupole/time-of-flight system (UPLC-QTOF). The antioxidant potential was verified by thin-layer chromatography (TLC). The direct and combined antifungal activity of the extract against opportunistic Candida strains was investigated using the microdilution method. The minimal fungicidal concentration (MFC) was determined by subculture, while the modulation of the morphological transition (fungal virulence) was evaluated by light microscopy. The in vitro antiparasitic activity was analyzed using epimastigotes of Trypanosoma cruzi and promastigotes of Leishmania braziliensis and Leishmania infantum, while cytotoxicity was determined in cultures of mouse fibroblasts. The phytochemical analysis identified the presence of acids, terpenes, flavonoids, lignans, and alkaloids. Among these constituents, the presence of polar and non-polar phenolic compounds with known antioxidant action washighlighted. While the extract showed clinically ineffective antifungal effects, it could enhance the effectiveness of fluconazole, in addition to inhibiting the morphological transition associated with increased virulence in Candida strains. Although the extract showed low cytotoxicity against fibroblasts, it also had weak antiparasitic effects. In conclusion, Croton heliotropiifolius is a source of natural products with antifungal and antioxidant potential.

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“…Neglected diseases typically affect tropical and subtropical regions, principally developing countries [ 1 , 2 ], with poor and marginalized people [ 3 ] being the most affected. According to the World Health Organization, neglected diseases affect more than 1 billion people around the world [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Alkyl and Aryl Derivatives Based on p-Coumaric Acid Modification and Inhibitory Action against Leishmania braziliensis and Plasmodium falciparum

et al. 2020

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In low-income populations, neglected diseases are the principal cause of mortality. Of these, leishmaniasis and malaria, being parasitic, protozoan infections, affect millions of people worldwide and are creating a public health problem. The present work evaluates the leishmanicidal and antiplasmodial action of a series of twelve p-coumaric acid derivatives. Of the tested derivatives, eight presented antiparasitic activities 1–3, 8–12. The hexyl p-coumarate derivative (9) (4.14 ± 0.55 μg/mL; selectivity index (SI) = 2.72) showed the highest leishmanicidal potency against the Leishmania braziliensis amastigote form. The results of the molecular docking study suggest that this compound inhibits aldehyde dehydrogenase (ALDH), mitogen-activated kinase protein (MPK4), and DNA topoisomerase 2 (TOP2), all of which are key enzymes in the development of Leishmania braziliensis. The data indicate that these enzymes interact via Van der Waals bonds, hydrophobic interactions, and hydrogen bonds with phenolic and aliphatic parts of this same compound. Of the other compounds analyzed, methyl p-coumarate (64.59 ± 2.89 μg/mL; IS = 0.1) demonstrated bioactivity against Plasmodium falciparum. The study reveals that esters presenting a p-coumarate substructure are promising for use in synthesis of derivatives with good antiparasitic profiles.

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Evaluation of antiparasitary, cytotoxic and antioxidant activity and chemical analysis of Tarenaya spinosa (Jacq.) Raf. (Cleomaceae)

Cited by 15 publications

References 39 publications

Biological potentialities and chemical composition of Tarenaya aculeata roots and stems

Biological potentialities and chemical composition of Tarenaya aculeata roots and stems

Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth

Alkyl and Aryl Derivatives Based on p-Coumaric Acid Modification and Inhibitory Action against Leishmania braziliensis and Plasmodium falciparum

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