“…It has been found also that metal complexes of these derivatives are more active than the parent thiophene derivatives. Copper complexes of many several ligands have been prepared and evaluated for anti-inflammatory [5][6][7][8][9][10], antioxidant [11][12][13][14][15] activity and irritancy after oral, subcutaneous, and local administration in rats and guinea pigs. Other compounds known for their antiinflammatory properties are the S, N-heterocyclic ligands, e.g., thiazoline and its derivatives [8,9].…”