2008
DOI: 10.1007/s00775-008-0409-0
|View full text |Cite
|
Sign up to set email alerts
|

Evaluation of antiproliferative activities and apoptosis induction caused by copper(II)–benzothiazolesulfonamide complexes in Jurkat T lymphocytes and Caco-2 cells

Abstract: Two copper(II) complexes with a benzothiazolesulfonamide ligand, [Cu(L)2(py)2] (1) and [Cu(en)2(L)2] (2) [HL is N-2-(4-methylbenzothiazole)toluenesulfonamide, py is pyridine, en is ethylenediamine], were prepared and then characterized with the aid of X-ray crystallography and spectroscopy. Whereas the copper(II) ion in 1 presents a square-planar geometry, in 2 it has a distorted octahedral environment. In addition, although the ligand is monodentate in both complexes, it exhibits different coordination behavi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

3
31
0

Year Published

2009
2009
2020
2020

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 28 publications
(35 citation statements)
references
References 47 publications
3
31
0
Order By: Relevance
“…The lowest IC 50 values, which are indicative of higher cytotoxicity, were measured for our complex. Interestingly, [Cu(N9-ABS)(phen) 2 ]Á3.6H 2 O is more active than the previously reported [Cu(L) 2 (py) 2 ]Á(HL = N-2-(4-methylbenzothiazole)toluenesulfonamide) [25]. Jurkat T lymphocytes proved to be more sensitive to our compound than Caco-2.…”
Section: Cytotoxicity Of the Complexmentioning
confidence: 56%
See 2 more Smart Citations
“…The lowest IC 50 values, which are indicative of higher cytotoxicity, were measured for our complex. Interestingly, [Cu(N9-ABS)(phen) 2 ]Á3.6H 2 O is more active than the previously reported [Cu(L) 2 (py) 2 ]Á(HL = N-2-(4-methylbenzothiazole)toluenesulfonamide) [25]. Jurkat T lymphocytes proved to be more sensitive to our compound than Caco-2.…”
Section: Cytotoxicity Of the Complexmentioning
confidence: 56%
“…This effect was also observed for the [Cu(phen) 2 ] 2+ complex. This difference in cell viability indicates that the activity of the complexes may be cell-type specific, although a contributing factor could be the easier access that toxic agents have to cells in suspension [25]. …”
Section: Cytotoxicity Of the Complexmentioning
confidence: 97%
See 1 more Smart Citation
“…The quotient g i /A i is an empirical measure for the degree of tetrahedral distortion. This quotient ranges from $105 to 135 cm for square-planar structures and increases markedly on the introduction of tetrahedral distortion [57]. In terms of the factor g i /A i , CuL4-1 appears to have some tetrahedral distortion of the copper(II) arrangement, being the complex structurally most similar to CuZnSOD [58] (Table 4).…”
Section: Complexmentioning
confidence: 97%
“…It has been found also that metal complexes of these derivatives are more active than the parent thiophene derivatives. Copper complexes of many several ligands have been prepared and evaluated for anti-inflammatory [5][6][7][8][9][10], antioxidant [11][12][13][14][15] activity and irritancy after oral, subcutaneous, and local administration in rats and guinea pigs. Other compounds known for their antiinflammatory properties are the S, N-heterocyclic ligands, e.g., thiazoline and its derivatives [8,9].…”
Section: Introductionmentioning
confidence: 99%