Evaluation of antipyretic potential of Leucas lavandulaefolia (Labiatae) aerial part extract

Mukherjee, Kakali; Saha, Basudeb

doi:10.1002/ptr.1013

Cited by 13 publications

(7 citation statements)

References 6 publications

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“…The modified methods by Mukherjee et al (2002), Akuodor et al (2011) and Essien et al (2015) were used for this study. Forty Wistar rats were randomly selected and divided into 8 groups of 5 rats per cage.…”

Section: Yeast-induced Pyrexiamentioning

confidence: 99%

Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves

Idakwoji¹,

Atanu²,

Nweje-Anyalowu³

et al. 2022

J Pharm Pharmacogn Res

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Context: The anti-nociceptive and anti-pyretic properties of the crude aqueous extract of Anogeissus leiocarpa (DC). Guill. & Perr. leaves have been reported. Aims: To investigate the anti-inflammatory, anti-nociceptive, and anti-pyretic properties of aqueous extract of A. leiocarpa leaves (AEAL) and its fractions to identify the bioactive compound(s). Methods: AEAL was fractionated successively and eluted in gradients of solvent mixture (n-hexane, ethylacetate, and methanol). Eluates, which showed similar TLC profiles were pooled to afford 5 fractions (F1-F5). AEAL and the fractions were subjected to phytochemical analysis and investigated for anti-inflammatory, anti-nociceptive, and anti-pyretic effects using carrageenan-induced paw edema and Brewer’s yeast-induced pyrexia in rats, and acetic acid-induced writhing in mouse models, respectively. Results: Phytochemical analysis indicated presence of terpenoids, saponins, steroids, glycosides, flavonoids, tannins and alkaloids. At 200 mg/kg b.w, AEAL and F1-F5 recorded significant (p<0.05) improvements in paw edema, abdominal constrictions and pyrexia, which is comparable to the standard (ketoprofen or Aspirin), relative to the control groups, with F4 observed to be the most potent fraction. GC-MS analysis of F4 reveal the presence of hexadecenoic acid, 15-methyl-, methylester, 9-oxabicyclo (6.1.0) nonane, cis-, cholest-4-en-3-one, cholesterol and 3-diazo-1-methyl-1, 3-dihydro-indol-2-one. Conclusions: The results indicate that identified compounds, particularly 3-dihydro-indol-2-one, could be responsible for the anti-inflammatory, anti-nociceptive, and anti-pyretic properties of the extract.

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Section: Yeast-induced Pyrexiamentioning

confidence: 99%

Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves

Idakwoji¹,

Atanu²,

Nweje-Anyalowu³

et al. 2022

J Pharm Pharmacogn Res

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“…The modified method by Mukherjee et al (2002), Akuodor et al (2011) and Essien et al (2015) was used for this study. Thirty Wistar rats were randomly selected and divided into 5 groups of 6 rats per cage.…”

Section: Yeast-induced Pyrexiamentioning

confidence: 99%

Anti-Inflammatory, Antipyretic and Anti-Nociceptive Activities of the Ethanol Stem Bark Extract of Salacia lehmbachii

Essien¹,

sup>EdidaraE.Thomas²,

Essiet³

et al. 2017

BJPT

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The aim of this study is to scientifically elucidate the effects of Ethanol Stem Bark Extract (ESBE) on inflammation, pyrexia and pains induced in rats and mice, following the claim that decoction from stem-bark of Salacia Lehmbachii (SL) is used in treating feverish and painful conditions in south-eastern parts of Nigeria. The anti-inflammatory activities of the ESBE of this plant were studied, using carrageenan and egg albumin-induced paw edemain albino Wistar rats; and antipyretic activities were examined, using Dinitrophenol and Brewer's yeastinduced pyrexia in Wistar rats, while acetic acid-induced writhing and tail immersion models were used for analgesic study. LD50 and ED50 of the ESBE were carried out to determine its safety and dosing regimen, respectively. Thirty animals were randomly selected and grouped into five with six animals per group for each experiment. Group 1 and 5 (controls) received 20 mL/kg of distilled water and150 mg/kg of aspirin and 10 mg/kg of morphine (tail immersion study) respectively; while groups 2 to 4 received 75, 150 and 300 mg/kg of the extract respectively. The ED50 was 150 mg/kg. The ESBE of SL exhibited significant (p<0.05) dose related effects in all the experimental models. Doses of 150 and 300 mg/kg abolished the induced edema, induced pyrexia and pains, highly comparable to respective positive controls. Therefore, ESBE of Salacia lehmbachii possesses potent antiinflammatory, antipyretic and analgesic activities, likely resulting from its phytochemical constituents. Hence, its folkloric use in herbal medicines for pains and fever is justified.

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“…This was carried out based on the method described by Mukherjee et al (2002). Rats were randomly divided into five groups of six rats each.…”

Section: Yeast-induced Hyperthermiamentioning

confidence: 99%

Analgesic and Antipyretic Activities of Drymaria cordata (Linn.) Willd (Caryophyllaceae) Extract

Akindele¹,

Ibe²,

Adeyemi³

2011

Afr. J. Trad. Compl. Alt. Med.

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Drymaria cordata (Linn.) Willd (Caryophyllaceae) is an herbaceous plant widely used in traditional African medicine (TAM) for the treatment of diverse ailments including painful and febrile conditions. This study was conducted to investigate the analgesic and antipyretic properties of the whole plant extract of D. cordata. The acetic acid-induced writhing, formalin, and tail clip tests were used to evaluate analgesic activity while the 2,4-dinitrophenol (DNP)-, d-amphetamine-, and yeast-induced hyperthermia tests were used to investigate antipyretic activity in rodents. D. cordata (100, 200, and 400 mg kg -1 , p.o) produced significant (p<0.05) analgesic activity in the mouse writhing, formalin (second phase), and tail clip tests. The effects of D. cordata were generally comparable to those of acetylsalicylic acid (ASA, 100 mg kg -1 , p.o) and morphine (2 mg kg -1 , s.c). Also, D. cordata produced significant (p<0.05) dose-dependent inhibition of temperature elevation in the 2,4-DNP and yeast-induced hyperthermia models with peak effects produced at the dose of 400 mg kg -1 . The effect at this dose was comparable to that of ASA in the two models. In the d-amphetamine method, D. cordata produced significant (p<0.05) dose-and time-dependent reduction of temperature elevation with peak effect produced at the dose of 200 mg kg -1 . The effect of the extract at this dose was greater than that of ASA. The results obtained in this study demonstrate that the aqueous whole plant extract of Drymaria cordata possesses analgesic and antipyretic properties mediated through peripheral and central mechanisms.

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Evaluation of antipyretic potential of Leucas lavandulaefolia (Labiatae) aerial part extract

Cited by 13 publications

References 6 publications

Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves

Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves

Anti-Inflammatory, Antipyretic and Anti-Nociceptive Activities of the Ethanol Stem Bark Extract of <em>Salacia lehmbachii</em>

Analgesic and Antipyretic Activities of <i>Drymaria cordata</i> (Linn.) Willd (Caryophyllaceae) Extract

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