Evaluation of antiretroviral effect on mitochondrial DNA depletion among HIV-infected patients in Bali

Masyeni, Sri; Sintya, Erly; Megawati, Dewi; Sukmawati, Ni Made Hegard; Budiyasa, Dewa G.; Aryastuti, Anak Agung Sri Agung; Khairunisa, Siti Qamariyah; Arijana, I Gusti Kamasan Nyoman; Nasronudin, N.

doi:10.2147/hiv.s166245

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…The main reason is that they were unaware of sexually transmitted illnesses and had unprotected intercourse with their clients. 36 Similar like Surabaya, an investigation in North Sulawaesi showed CRF01_AE gene is the major subtype of HIV-1 infection. 30 The major subtypes prevalent in another study in Papua and West Papua provinces are also CRF01_AE and subtype B.…”

Section: Discussionmentioning

confidence: 88%

“…39 Another evaluation of ARV effect in Bali reported that the patients who undergo more than12 months of NRTIs treatment show a decrease in the mtDNA:nDNA ratios. 36 Study in Surabaya showed that transmitted drug resistance of RT inhibitors was detected in 4.3% of the samples. 3 A study in Papua showed high prevalence of HIV-1 patient because health behavior that associated with social culture.…”

Section: Discussionmentioning

confidence: 99%

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A systematic review and meta-analysis of HIV transmission risk behaviors, genetic variations, and antiretroviral (ARV) resistance in LGBT populations

Sulistina,

Martini,

Prasetyo

et al. 2024

Journal of Public Health Research

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Background: Currently, human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) has become one of the major health problems worldwide, including Indonesia. East Java is one of the provinces in Indonesia with the highest prevalence of HIV infection. One of the causes of HIV infection transmission is lesbian, gay, bisexual, and transgender (LGBT) practice. Furthermore, the treatment using antiretroviral (ARV) drugs in HIV-1 patients can fail due to the presence of HIV drug resistance. Objective: The aim of this study is to identify the behavior at risk of HIV transmission among LGBT, patterns of genetic variation and antiretroviral (ARV) resistance. Methods: A systematic review and meta-analysis based on the PRISMA guidelines was conducted. We searched three databases including PubMed, ScienceDirect, and Google scholar for studies investigating the non-heterosexual behavior as risk factor of HIV infection and antiretroviral resistance. Only studies published in English are considered. The adjusted estimates of the risk were carried out using best-adjusted OR with 95% confidence interval (CI) and significant p value < 0.05. Results: In the quantitative analysis of HIV infection risk factors, a total of 13 studies were included, which investigated non-heterosexual behavior as a potential factor. The studies involved a total of 37,129 participants, comprising 10,449 individuals in the non-heterosexual behavior group (LGBTQ+) and 26,680 individuals in the heterosexual group. The majority of the participants in this study were from the USA, Japan, China, and Brazil, and the main HIV subgenotypes were B and CRF. Additionally, the antiretroviral resistance of HIV patients was examined, involving a total of 3062 individuals, with 1296 individuals in the non-heterosexual behavior group and 1766 individuals in the heterosexual group. Our calculation showed that non-heterosexual behavior was significant as risk factor of HIV infection (OR = 2.17, 95% CI = 1.94–2.43, p < 0.001) and antiretroviral resistance (OR = 1.31, 95% CI = 1.00–1.71, p = 0.05). Conclusion: This study concludes that non heterosexual behavior is significant risk factor of HIV infection. A quite prevalent of antiretroviral resistance were found among non heterosexual behavior. The main subgenotype of HIV are B and CRF.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of HIV transmission risk behaviors, genetic variations, and antiretroviral (ARV) resistance in LGBT populations

Sulistina,

Martini,

Prasetyo

et al. 2024

Journal of Public Health Research

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“…11,20 However, other studies found greater loss of mtDNA content over time with long-term treatment in HIVinfected children 4 and adults. 21,22 There are a number of possible explanations for mitochondrial impairment in our study sample of HIV-infected children with prolonged viral control who were initiated on ART early in life. Despite suppression of plasma VL to low concentrations, viral reservoirs 23 and viral associated proteins may persist, 24,25 thereby impairing mitochondrial function.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial Impairment in Well-Suppressed Children with Perinatal HIV-Infection on Antiretroviral Therapy

Shen

Liberty

Shiau

et al. 2020

AIDS Research and Human Retroviruses

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Mitochondrial impairment is reported in HIV-infected children receiving antiretroviral therapy (ART), as well as those naive to ART. Whether mitochondrial function recovers with early initiation of ART and sustained viral suppression on long-term ART is unclear. In this study, we evaluate mitochondrial markers in wellsuppressed perinatally HIV-infected children initiated on ART early in life. We selected a cross-sectional sample of 120 HIV-infected children with viral load <400 copies/mL and 60 age-matched uninfected children (22 HIV-exposed uninfected) enrolled in a cohort study in Johannesburg, South Africa. Complex IV (CIV) and citrate synthase (CS) activity were measured by spectrophotometry. Mitochondrial DNA (mtDNA) content relative to nuclear DNA (nDNA) was measured by quantitative real-time polymerase chain reaction and expressed as copies/nDNA. Mitochondrial markers were impaired in HIV-infected children, including lower mean CIV activities [1.76 vs. 1.40 optical densities (OD)/min], higher risk of a CIV/CS ratio £0.22 (third quartile; odds ratio = 3.03, 95% confidence interval: 1.38-6.66), and lower mtDNA content. Children with shorter versus longer ART duration (<6.3 vs. ‡6.3 years) had lower means of CIV activity (1.22-1.58 OD/min) and mtDNA content (386-907 copies/nDNA). There were no differences in mitochondrial markers between children who started ART earlier (<6 months) or later (6-24 months). CIV activity was impaired in children with lower height-for-age Z-scores (HAZs). Despite early treatment and prolonged viral suppression, HIVinfected children had detectable mitochondrial impairment, particularly among those with stunted growth. Further study is required to determine if continued treatment will lead to full recovery of mitochondrial function in HIV-infected children.

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“…The Cognitive Adaptive Test/Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS) was designed for use by primary pediatric health-care providers to screen children for cognitive delay using minimal equipment in a shorter time (usually 15-20 min) [4]. CAT/CLAMS has been demonstrated https://www.id-press.eu/mjms/index in normal children as well as high-risk groups of developmental delayed children between 1 and 36 months of age [7], [8]. This study aimed to assess the correlation of Capute score with CD4 count among HIVinfected children in Sanglah Hospital, Bali, Indonesia.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Capute Scores with CD4 Count among Human Immunodeficiency Virus-infected Children in Sanglah Hospital, Bali, Indonesia

Supadma¹,

Apsari²,

Wati³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Cognitive, motoric, and language development in a human immunodeficiency virus (HIV)-infected child is an important issue that affects developmental milestone and quality of life. The effect of HIV infection on cognitive function must be detected early to prevent delayed cognitive, motoric, and language function. AIM: This study aimed to assess the correlation of cognitive scores with CD4 count among HIV-infected children in pediatrics polyclinic Sanglah Hospital, Bali. METHODS: This cross-sectional study recruited 68 HIV-infected children age 0–36 months old as participants. Cognitive score was assessed using Cognitive Adaptive Test/Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS) scores and HIV status, and CD4 count was obtained from the medical record. RESULTS: The result showed that mean of CD4 count among subject was 29.85 cells/mm3, there was positive correlation between CAT scores with CD4 count (r = 0.33, p = 0.006) and also between CLAMS scores with CD4 count (r = 0.307, p = 0.01). CONCLUSION: It can be concluded that CD4 count correlated with Capute scores on HIV-infected children.

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Evaluation of antiretroviral effect on mitochondrial DNA depletion among HIV-infected patients in Bali

Cited by 5 publications

References 30 publications

A systematic review and meta-analysis of HIV transmission risk behaviors, genetic variations, and antiretroviral (ARV) resistance in LGBT populations

A systematic review and meta-analysis of HIV transmission risk behaviors, genetic variations, and antiretroviral (ARV) resistance in LGBT populations

Mitochondrial Impairment in Well-Suppressed Children with Perinatal HIV-Infection on Antiretroviral Therapy

Correlation of Capute Scores with CD4 Count among Human Immunodeficiency Virus-infected Children in Sanglah Hospital, Bali, Indonesia

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