Evaluation of antitumor and anti-angiogenic activity of bioactive compounds from Cinnamomum tamala : In vitro , in vivo and in silico approach

Thanekar, Deepavali R; Dhodi, Jayesh B.; Gawali, Nitin B.; Raju, Archana; Deshpande, Padmini S.; Degani, Mariam S.; Juvekar, Archana R.

doi:10.1016/j.sajb.2015.09.014

Cited by 18 publications

(10 citation statements)

References 32 publications

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“…This result suggests that the inhibition of cell viability may be related to the suppression of proliferation rather than to any cytotoxic or cytolytic effects. This activity might be due to the presence of specific compounds in parthenocarpic dates, like flavonoids glucosides (quercetin), which are known by their cancer chemoprotective attributes [ 25 ]. In this context, Rahmani et al [ 26 ] confirmed the therapeutic effects of P. dactylifera dates in preventing against cancer are due to its richness in polyphenolic compounds.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract fromPhoenix dactyliferaL. Parthenocarpic Dates

Abed

Chakroun

Abdelkafi-Koubaa

et al. 2018

BioMed Research International

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The aim of this study was to evaluate the antioxidant, the anti-inflammatory, and the antitumoral activities of the aqueous ethanolic extract from Phoenix dactylifera L. parthenocarpic dates. The antioxidant activity was carried using DPPH radical scavenging activity. The result showed that parthenocarpic dates had strongly scavenging activity on DPPH reaching 94% with an IC50 value of 0.15 ± 0.011 mg/mL (p < 0.05). The anti-inflammatory potential was determined by the inhibitory effect of the aqueous ethanolic extract on phospholipase A2 activity as well as on carrageenan-induced paw oedema in mice. The in vitro study showed that the extract inhibited the phospholipase A2 activity with an IC50 value of 130 μg/mL and the in vivo study showed a significantly decrease in the paw oedema after 1 h compared to the control group. Finally, the antiproliferative activity of the aqueous ethanolic extract was assessed by MTT test against MCF-7 and MDA-MB-231 cancer cell lines. This extract was effective in inhibiting MDA-MB-231 and MCF-7 cancer cells growth with IC50 values of 8 and 18 mg/mL, respectively, after 72 h treatment. These results confirm the ethnopharmacological significance of Phoenix dactylifera L. parthenocarpic dates, which could add support for its pharmaceutical use.

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Section: Resultsmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract fromPhoenix dactyliferaL. Parthenocarpic Dates

Abed

Chakroun

Abdelkafi-Koubaa

et al. 2018

BioMed Research International

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“…The effect of syringin on angiogenesis was evaluated through chorioallantoic membrane (CAM) assay as per the protocol of Thanekar et al 49 with minor modifications on the method of analyzing vascular branching and choice of positive control. A total of six fertilized duck eggs were tested per group and were incubated using an Incubox automatic turning incubator maintained at 37°C with 85% relative humidity.…”

Section: Methodsmentioning

confidence: 99%

<p>In Ovo and In Silico Evaluation of the Anti-Angiogenic Potential of Syringin</p>

Aventurado¹,

Billones²,

Vasquez³

et al. 2020

DDDT

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Introduction: Cancer is considered as one of the deadliest human diseases today. Angiogenesis, the propagation of new blood vessels from pre-existing vasculature, is a critical step in the progression of cancer as it is essential in the growth and metastasis of tumors. Hence, suppression of angiogenesis is a promising approach in cancer therapy. Syringin, a phenylpropanoid glycoside with a molecular formula of C 17 H 24 O 9 , has been found to exhibit chemopreventive effects. However, its anti-angiogenic activity and the underlying mechanism of action are still unknown. Methods: In this work, in ovo chorioallantoic membrane (CAM) assay has been conducted to evaluate the effect of syringin on neovascularization. Additionally, reverse molecular docking studies have been performed in order to identify the probable enzyme targets in the angiogenesis pathway. Results: Treatment with syringin showed significant dose-dependent inhibition of blood vessel length and junctions in the CAM of duck eggs; the anti-angiogenic activity of syringin at 100 µM and 200 µM is comparable with 200 µM of the positive control celecoxib. The results of reverse docking studies indicate that syringin binds the strongest to dihydrofolate reductase (DHFR) and, to some extent, with transforming growth factorbeta receptor type 1 (TGF-βR1), vascular endothelial growth factor receptor 2 (VEGFR2), and matrix metalloproteinase-2 (MMP-2). Furthermore, ADMET models revealed that syringin potentially possesses excellent pharmacokinetic and toxicity profiles. Conclusion: This study demonstrates the potential of syringin as an anti-angiogenic agent and elicits further investigations to establish its application in cancer suppression.

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“…T. Nees & Eberm. Monocyclic sesquiterpene α -Caryophyllene (Pubchem CID: 4444853) Lung, breast and brain cancer Thanekar et al (2016) 14. Allium sativum L. Organosulfur compound Allicin (Pubchem CID: 58548) Colon cancer Perez-Ortiz et al (2020) Diallyl sulphide (Pubchem CID: 11128) Colon, skin, breast prostate and upper digestive tract cancer Zheng et al (2016) ; Kunnumakkara et al (2018) S-Allyl-L-cysteine (Pubchem CID: 7969672) Prostate cancer Guldiken et al (2018) 15.…”

Section: Phytochemistry Of Indian Anticancer Dietary Spicesmentioning

confidence: 99%

Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways

Singh

Yadav

2022

Current Research in Food Science

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Evaluation of antitumor and anti-angiogenic activity of bioactive compounds from Cinnamomum tamala : In vitro , in vivo and in silico approach

Cited by 18 publications

References 32 publications

Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract fromPhoenix dactyliferaL. Parthenocarpic Dates

Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract fromPhoenix dactyliferaL. Parthenocarpic Dates

<p>In Ovo and In Silico Evaluation of the Anti-Angiogenic Potential of Syringin</p>

Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways

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