Evaluation of Antiviral Antibodies against Epstein-Barr Virus and Neurotransmitters in Patients with Fibromyalgia

Reshkova,; Kalinova, Desislava; Milanov, Ivan

doi:10.21767/2171-6625.100035

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…There are data on the role of various pathogens known to be risk factors for different autoimmune diseases (Epstein‒Barr virus, Herpes simplex virus, hepatitis virus C, Borrelia burgdorferi , etc.) in the etiology of FM [11,12,13]. In some cases FM can be temporally related to vaccination, silicone breast implants, or mineral oil injection as part of an autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome) [14,15,16].…”

Section: Pathogenesis Of Fm: Autoimmunitymentioning

confidence: 99%

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

Ryabkova

Чурилов

Shoenfeld

2019

IJMS

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Fibromyalgia is a disorder characterized by chronic widespread pain and non-pain symptoms, such as fatigue, dysautonomia, and cognitive and sleep disturbances. Its pathogenesis and treatment continue to be the subject of debate. We highlight the role of three mechanisms—autoimmunity, neuroinflammation, and small fiber neuropathy—in the pathogenesis of the disease. These mechanisms are shown to be closely interlinked (also on a molecular level), and the review considers the implementation of this relationship in the search for therapeutic options. We also pay attention to chronic fatigue syndrome, which overlaps with fibromyalgia, and propose a concept of “autoimmune hypothalamopathy” for its pathogenesis. Finally, we analyze the molecular mechanisms underlying the neuroinflammatory background in the development of adverse events following HPV vaccination and suggesting neuroinflammation, which could exacerbate the development of symptoms following HPV vaccination (though this is hotly debated), as a model for fibromyalgia pathogenesis.

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