Evaluation of anxiety-like behaviour in a rat model of acute postoperative pain

Kouya, Francois; Iqbal, Zohaib; Charen, Daniel A; Shah, Mansi; Banik, Ratan K.

doi:10.1097/eja.0000000000000052

Cited by 15 publications

(13 citation statements)

References 28 publications

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“…More recently, anxiety- and depression-like behaviors were investigated after plantar incision; for example, rats show an increase in anxiety-like avoidance behaviors in the light/dark box and an increase in depression-like behavior (sucrose preference test) for some days after incision. 86 , 168 Other studies assessing anxiety-like behavior after incision in rats gave similar results by using slightly different approaches and study designs. 36 , 97 Interestingly, the anxiety-like behavior lasted longer than hyperalgesia in 2 (but not one) of these studies.…”

Section: Animal-experimental Basic Researchmentioning

confidence: 89%

“…Systemic administration of gabapentin, or inhibition of ERK within the anterior cingulate cortex (ACC) early after surgery, but not systemic morphine, reduced incision-induced anxiety. 36 , 86 , 97 Interestingly, ERK-inhibition reduced anxiety-like behavior and mechanical hyperalgesia early after surgery (1 hour), but (different to inflammatory and neuropathic pain) in the later phase (6 hour), it exclusively reduced anxiety.…”

Section: Animal-experimental Basic Researchmentioning

confidence: 94%

See 1 more Smart Citation

Postoperative pain—from mechanisms to treatment

Pogatzki-Zahn

Segelcke

Schug

2017

PR9

284

216

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Section: Animal-experimental Basic Researchmentioning

confidence: 89%

Section: Animal-experimental Basic Researchmentioning

confidence: 94%

Postoperative pain—from mechanisms to treatment

Pogatzki-Zahn

Segelcke

Schug

2017

PR9

284

216

View full text Add to dashboard Cite

show abstract

“…Pain-induced negative sequelae can be more disabling than the pain itself, severely affecting the daily activities of patients with persistent pain [ 5 ]. Many studies on persistent pain have paid considerable attention to its effects on anxiety-like behavior [ 32 , 33 ]. It is necessary to distinguish the sensory and affective changes in pain treatment.…”

Section: Discussionmentioning

confidence: 99%

Strong Manual Acupuncture Stimulation of “Huantiao” (GB 30) Reduces Pain-Induced Anxiety and p-ERK in the Anterior Cingulate Cortex in a Rat Model of Neuropathic Pain

Shao

Shen

Sun

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Persistent neuropathic pain is associated with anxiety. The phosphorylation of extracellular signal-regulated kinase (p-ERK) in the anterior cingulate cortex (ACC) plays an important role in pain-induced anxiety. Acupuncture is widely used for pain and anxiety. However, little is known about which acupuncture technique is optimal on pain-induced anxiety and the relationship between acupuncture effect and p-ERK. The rat model was induced by L5 spinal nerve ligation (SNL). Male adult SD rats were randomly divided into control, SNL, strong manual acupuncture (sMA), mild manual acupuncture (mMA), and electroacupuncture (EA) group. Bilateral “Huantiao” (GB 30) were stimulated by sMA, mMA, and EA, respectively. The pain withdrawal thresholds (PWTs) and anxiety behavior were measured, and p-ERK protein expression and immunoreactivity cells in ACC were detected. PWTs increased significantly in both sMA and EA groups. Meanwhile, anxiety-like behavior was improved significantly in the sMA and mMA groups. Furthermore, the overexpression of p-ERK induced by SNL was downregulated by strong and mild manual acupuncture. Therefore, strong manual acupuncture on bilateral “Huantiao” (GB 30) could be a proper therapy relieving both pain and pain-induced anxiety. The effect of different acupuncture techniques on pain-induced anxiety may arise from the regulation of p-ERK in ACC.

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“…Human studies have shown a positive correlation between DED severity and symptoms of anxiety 7,[60][61][62] . While there have been some reports of increased signs of anxiety in chronic pain models, other reports have not found a significant effect of pain on anxiety measures [63][64][65][66][67][68][69][70] . Using the elevated plus maze, single LGE reduced open arm time only in female mice, whereas double LGE reduced open arm time in both female and male mice.…”

Section: Discussionmentioning

confidence: 93%

Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors

Mecum

Demers

Sullivan

et al. 2020

Sci Rep

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Lacrimal gland excision (LGE) induced dry eye produces more severe corneal damage in female mice, yet signs of LGE-induced ocular pain and anxiety in male and female mice have not been characterized. Excision of either the extraorbital gland (single LGE), or both the extraorbital and intraorbital glands (double LGE) was performed in male and female C57BL/6J mice to induce moderate and severe dry eye. Ongoing pain was assessed by quantifying palpebral opening and evoked nociceptive responses after corneal application of capsaicin and menthol. The open-field and plus maze were used to assess anxiety. Single LGE caused a reduction in palpebral opening and an increase in capsaicin and menthol-evoked responses only in female mice. Furthermore, single LGE produced signs of increased anxiety in female but not male mice. Overall, female mice appear more susceptible to signs of ocular pain, irritation, and anxiety in response to aqueous tear deficiency.

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Evaluation of anxiety-like behaviour in a rat model of acute postoperative pain

Abstract: We report that a rat model of acute postoperative pain is associated with anxiety-like increased light and open arm avoidance behaviour.

Cited by 15 publications

References 28 publications

Postoperative pain—from mechanisms to treatment

Postoperative pain—from mechanisms to treatment

Strong Manual Acupuncture Stimulation of “Huantiao” (GB 30) Reduces Pain-Induced Anxiety and p-ERK in the Anterior Cingulate Cortex in a Rat Model of Neuropathic Pain

Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors

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