Evaluation of Aquivion® as Recyclable Superacid Solid Catalyst in the Oxidation of Furfurylamines with Hydrogen Peroxide to 3‐Hydroxypyridines

Abstract

Furfurylamines are converted to 3‐hydroxypyridines by 1) oxidation with hydrogen peroxide to ring‐opened intermediates, with 2) a subsequent acid‐mediated cyclization/aromatization catalysed by the acidic and recyclable Aquivion catalyst eliminating neutralization steps. For substituted furfurylamines, the electronic effect of the substituents influence the conversion rate and this effect was correlated with Hammet's constants. Conversions up to 60 % were obtained for the most reactive furfurylamines.