Evaluation of Aromatherapeutic Potential of Allium cepa in Carbon Monoxide-induced Respiratory Tissue Toxicity in Wistar Rats

Ogadinma, Ilochi; Chuemere, A. N.; Vitalis, Vurey

doi:10.9734/ajrimps/2018/44256

Cited by 3 publications

(4 citation statements)

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“…Using standard procedures [7], the oxidative stress biomarkers assayed for include the antioxidant enzymes-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and non-antioxidant enzyme glutathione reductase (GSH). Other oxidative stress biomarkers that serve as secondary products of lipid metabolism which include malondialdehyde (MDA) and isoprostanes (F 2 isoP) were also assayed for.…”

Section: Biochemical Analysismentioning

confidence: 99%

“…GPx analysis was done by measuring the rate of NADPH oxidation. MDA was assayed for using thiobarbituric acid, F 2 isoP was assayed for using ELISA [7].…”

Section: Biochemical Analysismentioning

confidence: 99%

“…The high cost of medical procedures needed to manage these diseases can be a serious burden especially to low income earners. Because a considerable percentage of world's population are low income earners [7], it is therefore of utmost importance that alternative source of medicines are discovered to help reduce the difficulty faced by most people with respect to heart and kidney diseases. This study will determine the protective effect of avocado peel on antioxidant status of heart and kidney tissue homogenates in wistar rats.…”

Section: Introductionmentioning

confidence: 99%

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Dose-dependent Effect of Avocado Peel Hydroethanolic Extract on Antioxidant Status of Heart and Kidney Tissue Homogenates in Wistar Rats

Onoja

Chuemere

Tolunigba

et al. 2019

JAMPS

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This study evaluated the dose-dependent effect of avocado (Persea americana) peel hydroethanolic extract on antioxidant status of heart and kidney tissue homogenates in wistar rats. A total of 60 wistar rats were used and the study period lasted for 42 days. The animals were randomly sampled into six (6) groups; Group i-normal untreated wistar rats, ii-P. americana peel extract (50 mg/kg), iiilead acetate (100 mg/kg), iv-P. americana peel extract (50 mg/kg) + lead acetate (100 mg/kg), v-P. americana peel extract (100 mg/kg) + lead acetate (100 mg/kg) and vi-P. americana peel extract (150 mg/kg) + lead acetate (100 mg/kg). Biomarkers assayed for include antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase; non-enzyme antioxidant reduced glutathione; isoprostanes and malondialdehyde. The extract caused a dose-dependent increase in antioxidant enzymes and non-enzyme markers when administered alone and when combined with Original Research Article

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Section: Biochemical Analysismentioning

confidence: 99%

“…GPx analysis was done by measuring the rate of NADPH oxidation. MDA was assayed for using thiobarbituric acid, F 2 isoP was assayed for using ELISA [7].…”

Section: Biochemical Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dose-dependent Effect of Avocado Peel Hydroethanolic Extract on Antioxidant Status of Heart and Kidney Tissue Homogenates in Wistar Rats

Onoja

Chuemere

Tolunigba

et al. 2019

JAMPS

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“…nucifera is considered to be sterile unless the fruit is damaged from an external source [8] [9].Coconut water is rich in mineral content with high potassium and antioxidant contents which has various medical utilities. C. nuciferaalso contains cytokinin [10] which is one of themany beneficial components it is composed of.Around the world, C. nucifera juice has been used in popular medicine for the management of various diseases, such as arthritis, diarrhea, liver and kidney diseases [11].It is believed to be antigingivitic, febrifugal, antibronchitis and antiblenorrhagic. This study revealed further effect of C.nucifera juice on antioxidant/pro-oxidant ratio in brain tissue homogenate.…”

Section: Introductionmentioning

confidence: 99%

Changes in Antioxidant/Pro-Oxidant Ratio of Brain Tissue Homogenates in Response to Cocos nucifera Treatment

Ilochi

Augustine

Chuemere

2022

ACRI

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Objective: This study revealed the effect of Cocos nucifera juice on antioxidant/pro-oxidant ratio in brain tissue homogenates of wistar rats. Materials and Methods: 40 male wistar rats were collected and randomly selected into 4 groups. Treatment protocols were; i-normal saline, ii-3ml C. nucifera juice, iii-6ml C.nucifera juice, iv-9ml C. nucifera juice. The study period lasted for 42 days. Brain tissue homogenate was prepared and biochemical analysis for antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx); pro-oxidant biomarkers hydrogen peroxide (H2O2), thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) were assayed for. Results: The result showed that there was an increase in antioxidants concentration and a simultaneous decrease in pro-oxidant species generation as the dose of treatment was increased. The ratio of antioxidants to pro-oxidants showed a direct proportionality to the treatment dose. Conclusion: C. nucifera juice has the ability to improve the level of production or synthesis of the assayed antioxidant enzymes and also has the efficacy to suppress pro-oxidant specie generation.

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Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence

Beigoli

Behrouz

Memarzia

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The health benefits of Allium cepa (A. cepa) have been proclaimed for centuries. Various pharmacological and therapeutic effects on respiratory, allergic, and immunologic disorders are shown by A. cepa and its constituents. Flavonoids such as quercetin and kaempferol, alk(en)yl cysteine sulfoxides including S-methyl cysteine sulfoxide and S-propyl cysteine sulfoxide, cycloalliin, thiosulfinates, and sulfides are the main compounds of the plant. A. cepa displays broad-spectrum pharmacological activities including antioxidant, anti-inflammatory, antihypertensive, and antidiabetic effects. Our objective in this review is to present the effects of A. cepa and its constituents on respiratory, allergic, and immunologic disorders. Different online databases were searched to find articles related to the effect of A. cepa extracts and its constituents on respiratory, allergic, and immunologic disorders until the end of December 2020 using keywords such as onion, A. cepa, constituents of A. cepa, therapeutic effects and pharmacological effects, and respiratory, allergic, and immunologic disorders. Extracts and constituents of A. cepa showed tracheal smooth muscle relaxant effects, indicating possible bronchodilator activities or relieving effects on obstructive respiratory diseases. In experimental animal models of different respiratory diseases, the preventive effect of various extracts and constituents of A. cepa was induced by their antioxidant, immunomodulatory, and anti-inflammatory effects. The preventive effects of the plant and its components on lung disorders induced by exposure to noxious agents as well as lung cancer, lung infection, and allergic and immunologic disorders were also indicated in the experimental and clinical studies. Therefore, this review may be considered a scientific basis for development of therapies using this plant, to improve respiratory, allergic, and immunologic disorders.

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Evaluation of Aromatherapeutic Potential of Allium cepa in Carbon Monoxide-induced Respiratory Tissue Toxicity in Wistar Rats

Cited by 3 publications

References 0 publications

Dose-dependent Effect of Avocado Peel Hydroethanolic Extract on Antioxidant Status of Heart and Kidney Tissue Homogenates in Wistar Rats

Dose-dependent Effect of Avocado Peel Hydroethanolic Extract on Antioxidant Status of Heart and Kidney Tissue Homogenates in Wistar Rats

Changes in Antioxidant/Pro-Oxidant Ratio of Brain Tissue Homogenates in Response to Cocos nucifera Treatment

Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence

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