Evaluation of Associated Markers of Neonatal Pathological Jaundice Due to Bacterial Infection

Li, Yanli; Sun, Xiuhua; Wang, Yaqiong; Xing, Cuihong; Li, Li; Zhou, Shiying

doi:10.18502/ijph.v50i2.5394

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Inflammatory markers can help diagnose pathological jaundice due to bacterial infection. 17 Blood CRP can be used as a parameter for ongoing inflammation. 18 A study revealed that CRP >40mg/l had an infectious focus suggestive of bacterial infection.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of ROC curve evaluation of serum markers in acute cholecystitis with bacterial infection

Li¹,

Yue²,

Weng³

et al. 2022

J Pak Med Assoc

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Objective: To explore correlation of serum markers human neutrophil lipocalin and C-reactive protein with acute cholecystitis associated with bacterial infection, and to evaluate the diagnostic value of the markers. Method: The cross-sectional study was conducted from January 2018 to April 2020 at the Beijing Luhe Hospital, Capital Medical University, Beijing, China, and comprised acute cholecystitis patients who were divided into bacterial infection group A and non-bacterial infection group B. Serum human neutrophil lipocalin and C-reactive protein were measured for both the groups. Receiver operating characteristic curve was used to evaluate the diagnostic value of the two markers in acute cholecystitis associated with bacterial infection. Data was analysed using SPSS 25. Results: Of the 145 patients, 65(45%) were in group A; 36(55.38%) males and 29(44.62%) females with a mean age of 45.79±2.50 years. In group B there were 80(55%) subjects; 45(56.25%) males and 35(43.75%) females with a mean age of 46.16±2.52 years (p>0.05). In group A, there were 60(92.31%) cases of acute calculous cholecystitis, and 5(7.69%) had acute acalculous cholecystitis compared to 73(91.25%) and 7(8.75%), respectively, in group B (p>0.05). Serum human neutrophil lipocalin and C-reactive protein levels in group A were higher than group B (p<0.001). Serum human neutrophil lipocalin showed a high positive correlation with C-reactive protein in group A (r=0.800, p<0.001), and a moderate positive correlation in group B (r=0.683, p<0.001). Area under the curve of serum human neutrophil lipocalin associated with C-reactive protein was 0.901 ---Continue

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of ROC curve evaluation of serum markers in acute cholecystitis with bacterial infection

Li¹,

Yue²,

Weng³

et al. 2022

J Pak Med Assoc

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“…Entre os principais fatores de risco identificados na literatura, a prematuridade surge como um dos mais significativos. Recém-nascidos prematuros frequentemente apresentam imaturidade hepática e maior propensão à hemólise, aumentando assim o risco de hiperbilirrubinemia (Yanli et al, 2021). Além da prematuridade, a presença de condições clínicas que promovem a hemólise, como a incompatibilidade sanguínea materno-fetal, é um importante fator de risco para o desenvolvimento de icterícia neonatal.…”

Section: Identificação De Fatores De Riscounclassified

Bases Fisiopatológicas Da Icterícia Neonatal: Uma Revisão Bibliográfica

Mainardo Rodrigues Bezerra,

Silva de Brito,

Melo de Assis Dias

et al. 2024

RECIMA21

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Introdução: A icterícia neonatal é comum em recém-nascidos, afetando até 60% dos bebês saudáveis e até 80% dos prematuros. Apesar de geralmente benigna, pode levar a complicações neurológicas graves se não tratada adequadamente. A fisiopatologia envolve um desequilíbrio complexo no metabolismo da bilirrubina, incluindo imaturidade hepática e hemólise como fatores principais.Objetivo: Esta revisão visa sintetizar o conhecimento sobre as bases fisiopatológicas da icterícia neonatal, para subsidiar práticas clínicas baseadas em evidências. Métodos: Foram selecionados estudos originais e revisões publicados em periódicos revisados por pares nos últimos 20 anos, com foco em fatores de risco genéticos, ambientais e relacionados ao desenvolvimento neonatal associados à icterícia neonatal. Resultados e Discussão: A icterícia neonatal resulta de um desequilíbrio no metabolismo da bilirrubina, envolvendo produção, conjugação, excreção e metabolismo. Estudos destacam a imaturidade hepática e a hemólise como principais fatores. O monitoramento dos níveis de bilirrubina e intervenção terapêutica oportuna são cruciais para prevenir complicações graves. Conclusão: O entendimento dos mecanismos fisiopatológicos da icterícia neonatal é essencial para uma abordagem clínica eficaz. Investimentos contínuos em pesquisa e colaboração interdisciplinar oferecem perspectivas promissoras para avanços futuros no manejo dessa condição, visando melhorar os desfechos clínicos e a qualidade de vida dos recém-nascidos afetados.

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Maternal blood parameters and risk of neonatal pathological jaundice: a retrospective study

Jiang

Lü²,

Lin³

et al. 2023

Sci Rep

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This study aims to investigate the association between maternal blood parameters and the risk of neonatal pathological jaundice. A retrospective case–control study of 1309 newborns and their mothers from 2019 to 2020 in a single-center tertiary hospital. All mothers received a complete routine blood test prior to delivery, and outcome was neonatal pathological jaundice. We performed stepwise logistic regression modeling to identify maternal blood factors associated with neonatal pathological jaundice. 258 neonates (19.71%) were diagnosed with pathological jaundice. Logistic regression results showed that the odds ratio for pathological jaundice in neonates of mothers with high white blood cell (WBC) count was 1.512 (95% CI 1.145–1.998; P = 0.004). Besides, neonates whose mothers had a high mean corpuscular volume (MCV) during pregnancy doubled the odds of developing pathological jaundice (OR = 1.967; 95% CI 1.043–3.711; P = 0.037). Among neonates, those whose mothers had high levels of WBC count and MCV were at increased risk of pathological jaundice. Regular obstetric examinations and routine blood tests are essential to initiate adapted care.

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Evaluation of Associated Markers of Neonatal Pathological Jaundice Due to Bacterial Infection

Cited by 5 publications

References 20 publications

Diagnostic value of ROC curve evaluation of serum markers in acute cholecystitis with bacterial infection

Diagnostic value of ROC curve evaluation of serum markers in acute cholecystitis with bacterial infection

Bases Fisiopatológicas Da Icterícia Neonatal: Uma Revisão Bibliográfica

Maternal blood parameters and risk of neonatal pathological jaundice: a retrospective study

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