Evaluation of Association Between Q192R and L55M Genetic Polymorphisms of PON1 and Serum Paraoxonase-1 Activity in Healthy Individuals, a Meta-Analysis

Saadat, Mostafa

doi:10.2478/rjdnmd-2018-0020

Cited by 3 publications

(9 citation statements)

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“…Four metaanalysis studies selected our study as confirmatory regarding low PON1 activity and risk for CHD susceptibility, 61 weak association between PON1 R192 polymorphism and CHD risk, 62 relationship between vasospastic angina and PON1 Q192R polymorphism, 63 and connective confirmation between the Q192R PON1 polymorphism and the level of its enzymatic activity toward paraoxone as a substrate. 64 The importance of this PON1 coding polymorphism has also been demonstrated in findings by Abd Elgwad and coworkers, which estimated the response of the HDLcholesterol concentration to statin therapy. 65 They found that Q allele carriers responded better to statin therapy with respect to increased HDL-cholesterol concentration, than RR homozygotes.…”

Section: Pon1 and Vascular Diseasesmentioning

confidence: 81%

“…Our results support the notion that PON1 enzyme activity was better connected with disease status than phenotype alone and, in fact, PON1 status determination was more important than any of its elements separately. Four metaanalysis studies selected our study as confirmatory regarding low PON1 activity and risk for CHD susceptibility, weak association between PON1 R192 polymorphism and CHD risk, relationship between vasospastic angina and PON1 Q192R polymorphism, and connective confirmation between the Q192R PON1 polymorphism and the level of its enzymatic activity toward paraoxone as a substrate .…”

Section: Pon1 and Diseases Connected With Atherosclerosis Developmentmentioning

confidence: 95%

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Paraoxonase 1 and atherosclerosis‐related diseases

et al. 2019

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A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high‐density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti‐inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis‐related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end‐stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features.

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Section: Pon1 and Vascular Diseasesmentioning

confidence: 81%

Section: Pon1 and Diseases Connected With Atherosclerosis Developmentmentioning

confidence: 95%

Paraoxonase 1 and atherosclerosis‐related diseases

et al. 2019

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Section: Discussionmentioning

confidence: 99%

“…A meta-analysis study by Saadat [24] reported that RR genotype is significantly associated with increased PON1 enzyme activity in healthy individuals; however, a remarkable heterogeneity between the included studies was also present. As evident from a multitude of studies, the frequency of the polymorphic alleles and haplotypes of PON1 differs among various ethnic groups [24,25]. The conflicting results in the association of the Q192R polymorphism with the increased risk of CAD may also be due to variations in sample size, genotyping methods, pathological states, and diverse environmental influences [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Association between PON1 rs662 gene polymorphism and serum paraoxonase1 level in coronary artery disease patients in Northern India

Kumar

Saini

Kaur

et al. 2021

Egypt J Med Hum Genet

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Background Coronary artery disease (CAD) is a leading cause of morbidity and mortality, with a shifting trend towards the younger population. Paraoxonase1 (PON1) is a glycoprotein enzyme associated with high-density lipoprotein (HDL) particles in the blood. It has the ability to protect against lipid oxidation, thereby reducing the risk of atherogenesis. PON1 rs662 gene polymorphism may affect serum PON1 levels as well as its activity and may have a significant role in the pathogenesis of CAD. The present study was conducted to identify the association of PON1 rs662 gene polymorphism with serum PON1 levels in CAD patients in the North Indian population. This case–control study included 71 angiography-proven CAD patients (with > 50% luminal stenosis in one or more coronary arteries) and 71 controls (with < 50% luminal obstruction in angiography). PON1 rs662 gene polymorphism was studied using PCR and RFLP under the standardized protocol. Serum PON1 levels were estimated by ELISA. Results The serum PON1 level was significantly lower in the CAD group than in the controls (7.79 ± 3.16 vs. 10.79 ± 3.19 ng/mL; p < 0.0001). Logistic regression analysis showed that homozygous GG genotype of PON1 rs662 SNP has ninefold increased risk of developing CAD in an Indian population (OR = 9.0, 95%CI 2.79–29.06, p = 0.0002). A significantly higher frequency of G allele was also observed in CAD patients than in controls (OR 2.64, 95%CI 1.61–4.33, p = 0.001). Conclusions The reduced serum PON1 level is associated with CAD. PON1 rs662 gene polymorphism is significantly associated with CAD susceptibility in the North Indian population.

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“… 9 It is well acknowledged that the R192 and M55 alleles are related with augmented and reduced enzyme activity, respectively. 10 …”

Section: Introductionmentioning

confidence: 99%

Prevalence and mortality of COVID-19 are associated with the L55M functional polymorphism of Paraoxonase 1

Saadat

2021

Proceedings of Singapore Healthcare

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Introduction Accumulating evidence recommends that infectious diseases including coronavirus disease 2019 (COVID-19) are often associated with oxidative stress and inflammation. Paraoxonase 1 ( PON1, OMIM: 168,820), a member of the paraoxonase gene family, has antioxidant properties. Enzyme activity of paraoxonase depends on a variety of influencing factors such as polymorphisms of PON1, ethnicity, gender, age, and a number of environmental variables. The PON1 has two common functional polymorphisms, namely, Q192R (rs662) and L55M (rs854560). The R192 and M55 alleles are associated with increase and decrease in enzyme activity, respectively. Objective The present study was conducted to investigate the possible association of rs662 and rs854560 polymorphisms with morbidity and mortality of COVID-19. Methods Data for the prevalence, mortality, and amount of accomplished diagnostic test (per 106 people) on 25 November 2020 from 48 countries were included in the present study. The Human Development Index (HDI) was used as a potential confounding variable. Results The frequency of M55 was positively correlated with the prevalence (partial r = 0.487, df = 36, p = 0.002) and mortality of COVID-19 (partial r = 0.551, df = 36, p < 0.001), after adjustments for HDI and amount of the accomplished diagnostic test as possible confounders. Conclusions This means that countries with higher M55 frequency have higher prevalence and mortality of COVID-19.

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Evaluation of Association Between Q192R and L55M Genetic Polymorphisms of PON1 and Serum Paraoxonase-1 Activity in Healthy Individuals, a Meta-Analysis

Cited by 3 publications

References 46 publications

Paraoxonase 1 and atherosclerosis‐related diseases

Paraoxonase 1 and atherosclerosis‐related diseases

Association between PON1 rs662 gene polymorphism and serum paraoxonase1 level in coronary artery disease patients in Northern India

Prevalence and mortality of COVID-19 are associated with the L55M functional polymorphism of Paraoxonase 1

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