Evaluation of Association between Vaginal Infections and High-Risk Human Papillomavirus Types in Female Sex Workers in Spain

Abstract

Background. Infection with and persistence of high-risk human papillomavirus (HR-HPV) are the strongest risk factors for cervical cancer. In addition, other genital microorganisms may also be involved in the progression of HPV-associated lesions. Objetive. To evaluate the association of the vaginal microbiota (Candida spp., Trichomonas vaginalis, and bacterial vaginosis) with HR-HPV infection in Spanish female sex workers (FSWs). Methods. This cross-sectional study involved 208 (FSWs; age, 18–49 years) who visited a sexually transmitted infection (STI) information and prevention center (SERGAS) between January 2010 and December 2011. Face-to-face interviews were carried out. Cervical and vaginal samples were examined for human papillomavirus (HPV), Trichomonas vaginalis, Candida spp., and microorganisms related to bacterial vaginosis (BV). Results. HR-HPV was found to be significantly associated with BV in FSWs with positive results for HPV16-related types (31, 33, 35, and 52). T. vaginalis was isolated in FSWs with the following HR-HPVs: 18, 45, 66, and 68. Candida spp. were isolated only in FSWs with HPV 18-positive infection. Conclusion. We demonstrate a significant prevalence of HR-HPVs in FSWs with disturbances in the vaginal microbiota.

Influence of human papillomavirus infection on the vaginal microbiome of women with immunocompetency

“…These data conflicts may be the result of the different methods applied in each study. A positive relationship between BV and HPV was observed in a population of sex workers, which was very different from our sample group (21) . Murta et al (20) also found an association between vaginosis and papillomavirus; however, this study used a cytological diagnosis of HPV, which is significantly less sensitive than HC2.…”

“…are likely to possess a healthy Lactobacillus-dominated vaginal microbiome, in contrast to women with bacterial vaginosis (21) . Dols et al (22) showed that, in women with HPV, the prevalence of Lactobacillus crispatus was significantly reduced and that there was a shift in the composition of the Lactobacillus microbiota following HPV infection.…”

Molecular analysis and conventional cytology: association between HPV and bacterial vaginosis in the cervical abnormalities of a Brazilian population

“…BV may cause damage to the vaginal epithelium by degrading the cervical mucus with proteases and changing the physicochemical and immunological environment of the vaginal niche, allowing the entry of pathogens (Rodriguez-Cerdeira et al, 2012). The role of G. vaginalis, Mobiluncus, and other anaerobic microorganisms involved in the process of BV could be linked to an inhibition of neutrophil chemotaxis arising from the effects of succinic and acetic acids produced in anaerobic conditions.…”

Optimization of postoperative period after surgical interventions on the cervix

“…На сегодняшний день, помимо высокого уровня инфекционной заболеваемости среди населения, обусловленной увеличением чи-сла инфекций, передающихся половым путем (ИППП), и ростом полимикробных ассоциаций, большую роль играет растущая антибиотико-резистентность микроорганизмов, к которой приводит широкое и часто бесконтрольное применение антибактериальных препаратов [3,4,[6][7][8]. В последнее время послеоперацион-ные воспалительные осложнения характери-зуются стертым течением и зачастую проявля-ются в виде нарушений эпителизации раневой поверхности.…”

“…Учитывая, что дисплазия, как правило, ассо-циирована с инфекцией вирусом папилломы человека (ВПЧ) и часто протекает на фоне бактериального вагиноза [2][3][4][5][6], проблема профилактики послеоперационных воспали-тельных осложнений занимает важное место во врачебной деятельности специалистов, занимающихся проблемами патологических процессов ШМ.…”