Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development

Abstract

The reward sensation after food intake may be different between individuals and variants in genes related to the dopaminergic system may indicate a different response in people exposed to the same environmental factors. This study investigated the association of TaqIA (rs1800497) and -141C InsDel (rs1799732) variants in DRD2/ANKK1 gene with food intake and adiposity parameters in a cohort of children. The sample consisted of 270 children followed until 7 to 8 years old. DNA was extracted from blood and polymorphisms were detected by PCR-RFLP analysis. Food intake and nutritional status were compared among individuals with different SNP genotypes. Children carrying the A1 allele (TaqIA) had higher energy of lipid dense foods (LDF) when compared with A2/A2 homozygous children at 7 to 8 years old (GLM p=0.004; Mann Whitney p=0.005). No association was detected with -141C Ins/Del polymorphism. To our knowledge, this is the first association study of the DRD2 TaqIA and -141C Ins/Del polymorphism with food intake and anthropometric parameters in children. DRD2 TaqIA polymorphism has been associated with a reduction in D2 dopamine receptor availability. Therefore, the differences observed in LDF intake in our sample may occur as an effort to compensate the hypodopaminergic functioning.

No association of the dopamine D2 receptor genetic bilocus score (rs1800497/rs1799732) on food addiction and food reinforcement in Chilean adults

“…In contrast, participants with the genotype A1/A1 had a higher BMI and A1/A2 carriers had greater reinforcement of food. A1 alleles were also associated with a higher intake of fat (Feistauer et al, 2018).…”

“…The -141C Ins/del polymorphism (rs1799732) in the DRD2 gene, which results in the depletion of one of two 10.3389/fnbeh.2023.1067384 cytosines, has been shown to be associated with addiction. It has been associated with several CNS disorders, including alcohol dependence, suicide attempts, and psychiatric disorders (Feistauer et al, 2018), and the associated mechanism is a decreased expression of DRD2 (Arinami et al, 1997).…”

CLASH-VLT: a full dynamical reconstruction of the mass profile of Abell S1063 from 1 kpc out to the virial radius

“…ANKK1 and DRD2 genes belong to the same gene cluster, the NTAD cluster, an ancient cluster of which genes are apparently coregulated and may have emerged when the central nervous system became more complex (Feistauer, Vitolo, Campagnolo, Mattevi, & Almeida, 2018;Mota, Araujo-Jnr, Paixão-Côrtes, Bortolini, & Bau, 2012). A few in vitro studies with ANKK1 gene mRNAs and proteins were able to show the potential connection between this gene and the dopaminergic system (Feistauer et al, 2018;Garrido et al, 2011;Hoenicka et al, 2007).…”

Physical activity and gene association with human obesity

“…The DRD2 gene is probably regulated by ankyrin repeat and kinase domain containing 1 gene (ANKK1) through Nuclear Factor-kappaB (NF-kB). Genetic variations in DRD2 can alter dopamine signalling and modify the rewarding effects of food; moreover, some studies investigated the association of the DRD2 polymorphisms with BMI and hedonic hunger [53], since dopamine plays an important role in the regulation of appetite and the growth hormone [54][55]. Furthermore, variations in the FTO gene are the strongest polygenic determinants of obesity [56], and inactivation of this gene impairs DRD2-dependent neurotransmission and function in rodents [57].…”