Evaluation of Association of Vitamin D Receptor Genetic Polymorphism with Severe Chronic Periodontitis in an Ethnic Tamilian Population

Ratheesh, Vaishnavi; Subramanian, Sangeetha; Prakash, P S G; Victor, Dhayanand John

doi:10.1089/gtmb.2018.0190

Cited by 14 publications

(8 citation statements)

References 29 publications

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“…We found no association between both ApaI and TaqI polymorphisms and periodontitis; therefore, both VDR ApaI and TaqI polymorphisms may not carry a risk for periodontitis among Saudis. Similar results were obtained with other investigators in different ethnic populations (Turkish population, 21 Han Chinese subjects, 22 Colombian population, 23 Iranian population, 24 Taiwanese Han ethnic population, 25 the Tamilian population, 26 and the Western Romanian population 27 ). However, contrary results were obtained with other investigators.…”

Section: Discussionsupporting

confidence: 90%

Analysis of Vitamin D Receptor Gene Polymorphism in Chronic Periodontitis among Saudi Population

Elfasakhany

Al-Qahtani

Badri

et al. 2021

European Dental Research and Biomaterials Journal

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Objective Genetic and environmental factors have important roles in the development of periodontitis. We aimed to assess the relation of vitamin D receptor (VDR) ApaI and TaqI polymorphisms and the susceptibility of periodontitis in Saudi population in Makkah region. Materials and Methods In total, 86 unrelated patients with moderate-to-severe periodontitis and 86 controls were enrolled in this study. Evaluation of the periodontal state was performed by using plaque index, bleeding on probing, probing depth, and attachment loss. Extraction of genomic DNA from peripheral blood and genotyping of VDR gene ApaI G/T (rs7975232) and TaqI T/C (rs731236) polymorphisms were performed by utilizing polymerase chain reaction and restriction digestion. Results There were statistically significant differences between both groups regarding the mean bleeding on probing, mean probing depth, mean plaque index, and the mean attachment level (p < 0.001) indicating that the matching based on the investigated groups was adequate. The examined populations were in Hardy-Weinberg equilibrium. Analysis of the genotype and allele frequencies of both VDR ApaI and TaqI single nucleotide polymorphisms revealed that they were statistically indifferent between the control group and the periodontitis subjects (p> 0.05). Conclusion These results suggested that VDR ApaI and TaqI polymorphisms might not be related to the susceptibility of periodontal disease in the Saudi subjects in Makkah region.

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Section: Discussionsupporting

confidence: 90%

Analysis of Vitamin D Receptor Gene Polymorphism in Chronic Periodontitis among Saudi Population

Elfasakhany

Al-Qahtani

Badri

et al. 2021

European Dental Research and Biomaterials Journal

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“…Periodontitis is a common dental disease that is present worldwide. It is characterized by inflammatory responses to elevated levels of subgingival pathogens, causing damage to the soft tissues and alveolar bones supporting the teeth [1,2]. It is reported that mild to moderate periodontitis affects up to 50% of adults [3].…”

Section: Introductionmentioning

confidence: 99%

Abnormal expression of long noncoding RNA FGD5-AS1 affects the development of periodontitis through regulating miR-142-3p/SOCS6/NF-κB pathway

Chen

Ze-dong

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Periodontitis refers to the inflammation of gums and the surrounding structures and caused by a bacterial infection. The infection occurs owing to poor oral hygiene and could destroy the bone and the gum over time if left untreated. The present study identified the involvement of a key long noncoding RNA (lncRNA), i.e. FGD5-AS1, in the pathogenesis of periodontitis by assessing its expression in the gingival tissues of patients diagnosed with chronic periodontitis (CP). Overexpression of FGD5-AS1 in primary human periodontal ligament cells (PDLCs) significantly reduced the lipopolysaccharide (LPS)induced periodontitis, whereas its suppression aggravated this injury. Moreover, the miR-142-3p was markedly expressed in the gingival samples of patients diagnosed with CP and LPS-induced PDLCs. We found that the FGD5-AS1-mediated reduction in the inflammation was mediated through downside regulation of miR-142-3p, as evident from the upregulation of SOCS6, a target gene of miR-142-3p. Furthermore, the association between FGD5-AS1 and NF-jB pathway was detected. FGD5-AS1 was found to protect against LPS-stimulated PDLC injury through restraining the NF-jB signals. Based on these findings, we conclude that up-regulation of lncRNA FGD5-AS1 could protect against periodontitis via regulating the miR-142-3p/SOCS6/NF-jB signals. Therefore, the FGD5-AS1/miR-142-3p/SOCS6 axis may act as an important indicator in explaining the pathogenesis of periodontitis.

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“…11 Some of these genetic polymorphisms were previously studied in the dental caries aetiology context; [12][13][14][15][16][17] however, the results are contradictory. Following a similar pattern, studies evaluating periodontal disease [18][19][20][21][22][23][24][25] investigated the association between many genetic polymorphisms in VDR in the aetiology of periodontal diseases, including gingivitis. 15 Dental caries and gingivitis are common non-communicable diseases in children.…”

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confidence: 99%

Vitamin D receptor FokI and BglI genetic polymorphisms, dental caries, and gingivitis

Barbosa

Lima

Reis

et al. 2020

Int J Paed Dentistry

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Evaluation of Association of Vitamin D Receptor Genetic Polymorphism with Severe Chronic Periodontitis in an Ethnic Tamilian Population

Cited by 14 publications

References 29 publications

Analysis of Vitamin D Receptor Gene Polymorphism in Chronic Periodontitis among Saudi Population

Analysis of Vitamin D Receptor Gene Polymorphism in Chronic Periodontitis among Saudi Population

Abnormal expression of long noncoding RNA FGD5-AS1 affects the development of periodontitis through regulating miR-142-3p/SOCS6/NF-κB pathway

Vitamin D receptor FokI and BglI genetic polymorphisms, dental caries, and gingivitis

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