Evaluation of asthma medication adherence rates and strategies to improve adherence in the underserved population at a Federally Qualified Health Center

Bidwal, Monica K.; Lor, Kajua B.; Yu, Junhua; Ip, Eric J.

doi:10.1016/j.sapharm.2016.07.007

Cited by 57 publications

(64 citation statements)

References 25 publications

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“…Fiftytwo (46%) of 114 patients with asthma were accordingly classified as non-adherent, which is similar to the rate reported in our previous study (24,29). Age is associated with adherence to asthma inhalation treatment, with some studies revealing younger patients to be more non-adherent than older adults (29)(30)(31). Middleaged (50 to 64 years old) asthmatic patients were more than 30% less likely to use daily asthma medication compared to adults aged ≥65 years in the United States (32).…”

Section: Discussionsupporting

confidence: 81%

Optimal cut-off value and clinical usefulness of the Adherence Starts with Knowledge-12 in patients with asthma taking inhaled corticosteroids

Takemura¹,

Nishio²,

Fukumitsu³

et al. 2017

J. Thorac. Dis.

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Background: Non-adherence to inhalation regimens is common in asthmatic patients. The Adherence Starts with Knowledge-12 (ASK-12) survey was developed to detect and address patient-specific barriers to medication adherence. Our objective is to investigate the clinical usefulness of the ASK-12 for assessing and addressing adherence to inhalation therapy in asthma. Methods: The ASK-12 was administered to 138 asthmatic patients. Using pharmacy-refill data, we examined the cut-off value of the ASK-12 to identify patients who were non-adherent to inhalation regimens and identify factors associated with non-adherence. To verify the usefulness of the ASK-12, inhalation regimens were prospectively switched to less-expensive and simpler (once-daily) dosing regimens in eight non-adherent asthmatic patients who reported specific-barriers in "inconvenience of twice-daily inhaler use" and "cost".Results: Valid responses were received from 114 (82.6%) patients. A significant correlation was found between pharmacy-refill rates and the ASK-12 total score (r=−0.55, P<0.0001). The optimal cut-off value of the ASK-12 total score to discriminate non-adherent patients (defined by pharmacy-refill rate <80%) was 23, with 71.4% specificity and 93.3% sensitivity. Using this value, 52 (45.6%) patients were classified as nonadherent. Univariate followed by multivariate analysis identified younger age as a predictor of non-adherence to inhalation regimens (odds ratio, 2.67; 95% CI, −0.95 to −0.06; P=0.027). Switching inhaled medicines in eight patients resulted in significant improvements in both ASK-12 scores and asthma control. Conclusions:The ASK-12 is a brief, practical, and clinically useful measure for assessing and addressing adherence to inhalation regimens in asthma.

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Section: Discussionsupporting

confidence: 81%

Optimal cut-off value and clinical usefulness of the Adherence Starts with Knowledge-12 in patients with asthma taking inhaled corticosteroids

Takemura¹,

Nishio²,

Fukumitsu³

et al. 2017

J. Thorac. Dis.

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“…Besides, in the β-blocker Heart Attack Trial, patient with very poor adherence was linked and associated with higher mortality risk regardless of whether that patients were randomized to antihypertensive propranolol or placebo. 9,10 Similar findings were showed in the Canadian Amiodarone Myocardial Infarction Arrhythmia Trial (CAMIAT) study on the patient's sudden death, total cardiac mortality and all-cause mortality and in the CHARM program for all-cause mortality. It explains that patients who take their medication regularly as requested by the health care provider are also more likely to perform other healthy behaviours and physical activities, such as eating properly and exercising regularly at least 3 times a week.…”

Section: Healthy Adherer Effectsupporting

confidence: 65%

“…Other than that, in the chronic coronary artery disease, non-adherence to cardio protective medications such as β-blockers, statins and/or angiotensin-converting enzyme inhibitors was parallel with about 10% to 40% relative increase in risk of cardiovascular warded and a 50% to 80% relative increase in risk of mortality of that non-adherence patient. 9 Another studies showed that patients omitting Clopidogrel 75 mg within 1 month post hospitalization for acute myocardial infarction and drug-eluting stent placement were significantly will have an adverse outcome, thus end up with increasing trend of re-hospitalization and mortality, in the subsequent next 11 months. that adherence and compliance to cardiovascular medications was not directly associated with hospitalization for lung, prostate, or breast cancer and finally concluded that the benefit of adherence was directly related to the cardiovascular medication rather than other causes like epiphenomenon of a healthy adherer effect as discussed earlier.…”

Section: Relationship Between Medication Adherence and Patient Outcomesmentioning

confidence: 99%

Difficulties Facing the Patients and Extra Burden for Healthcare Providers by Non-adherence to the Medications - A Comprehensive Review

Hassan

Al-Temimi²,

Ramli

et al. 2019

IJPER

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Background: Compliance is commonly and always being confused with concordance, which is a process by which a patient and health care provider make discussion and decisions together about treatment and their outcomes. General worldwide, noncompliance is a major obstacle and main challenges to the effective and efficient health care delivery. Estimation in 2003 by the World Health Organization indicates that only approximately 50% of chronic diseases patients that us living in developed countries follow their treatment as scheduled and recommended by clinicians. Objectives: To report on the status and future trends of Medications adherence. Materials: Published journal article and conference reports. Method: Data Extraction, data on area related to the patients and healthcare providers for non-adherence to the Medications were gleaned from various publications. Results and Conclusion: Low compliance to prescribed medical is a complex problem, especially for patients with a chronic illness. With increasing numbers of medications shown to do better than harm when taken as prescribed, low compliance is a growing concern, seriously undermining the benefits of current medical care. Medical non-compliance has been identified as a major public health problem that imposes a considerable financial burden upon modern health care systems.

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“…The majority of adherence interventions primarily target children with controller medication adherence <80% assuming that children >80% at initial assessment will remain adherent. There is evidence that adherence is not a stable phenomenon (17)(18)(19)(20), although there is a paucity of data on patterns of adherence among individuals with asthma and none within sub-groups of Latino children (21). Souverein et al (17) examined longitudinal patterns of inhaled corticosteroid (ICS) medication initiation (21) among a sample of long term care patients (n=13,922).…”

Section: Abstract Word Count: 350mentioning

confidence: 99%

Longitudinal Patterns of Mexican and Puerto Rican Children’s Asthma Controller Medication Adherence and Acute Healthcare Use

Arcoleo¹,

McGovern

Kaur

et al. 2019

Annals ATS

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CM assisted in conducting the literature review, drafting the Introduction, contributed to the interpretation of data and content of the Conclusions section, and reviewed and provided final approval for the submission. KK was responsible for cleaning the Doser adherence data and variable creation, contributed to the interpretation of data and content of the Conclusions section, and reviewed and provided final approval for the submission. JH provided substantial input on the interpretation of the results, drafting the Introduction and Conclusions sections, and reviewed and provided final approval for the submission. JM participated in drafting the Introduction and Conclusions sections, interpretation of the results and reviewed and provided final approval for the submission. HC assisted KA with the SEM and LLCA analyses, interpretation of the data, and reviewed and provided final approval for the submission. DR participated in drafting the Introduction and Conclusions sections, interpretation of the results, and reviewed and provided final approval for the submission. JF participated in the design of the main study, supervised the cleaning and variable creation from the adherence data, drafting the Introduction and Conclusions sections, interpretation of the results, and reviewed and provided final approval for the submission.

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Evaluation of asthma medication adherence rates and strategies to improve adherence in the underserved population at a Federally Qualified Health Center

Cited by 57 publications

References 25 publications

Optimal cut-off value and clinical usefulness of the Adherence Starts with Knowledge-12 in patients with asthma taking inhaled corticosteroids

Optimal cut-off value and clinical usefulness of the Adherence Starts with Knowledge-12 in patients with asthma taking inhaled corticosteroids

Difficulties Facing the Patients and Extra Burden for Healthcare Providers by Non-adherence to the Medications - A Comprehensive Review

Longitudinal Patterns of Mexican and Puerto Rican Children’s Asthma Controller Medication Adherence and Acute Healthcare Use

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