Evaluation of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Atrial Granules of Rats with Experimental Congestive Heart Failure

Bialik, Gad M.; Abassi, Zaid; Hammel, Ilan; Winaver, Joseph; Lewinson, Dina

doi:10.1177/002215540104901012

Cited by 21 publications

(16 citation statements)

References 27 publications

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“…However, these results are not necessarily inconsistent with reported decreases in serum ANF and BNP protein as a result of LVAD support 25 because ANF and BNP are stored in regulated secretory granules and are released on stimulation. 26,27 It would not be surprising that the serum levels of proteins released from the regulated secretory pathway are at best loosely associated with their message levels. Given the extremely variable levels of expression of natriuretic peptides among patients and within regions of the heart, generalizations may not be possible.…”

Section: Discussionmentioning

confidence: 99%

Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support

Rodrigue-Way

Burkhoff

Geesaman³

et al. 2005

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support

Rodrigue-Way

Burkhoff

Geesaman³

et al. 2005

The Journal of Heart and Lung Transplantation

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“…Hoffman et al [6] demonstrated that rats ACF have high levels of BNP in the plasma. Similarly, the enhanced plasma levels of BNP coincides with overexpression of BNP in the myocardium of rats with ACF [128], corresponding with the high volume overload and cardiac hypertrophy characterizing this model of CHF.…”

Section: Cardiac Manifestationmentioning

confidence: 99%

Aortocaval Fistula in Rat: A Unique Model of Volume‐Overload Congestive Heart Failure and Cardiac Hypertrophy

Abassi

Goltsman²,

Karram

et al. 2011

BioMed Research International

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121

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Despite continuous progress in our understanding of the pathogenesis of congestive heart failure (CHF) and its management, mortality remains high. Therefore, development of reliable experimental models of CHF and cardiac hypertrophy is essential to better understand disease progression and allow new therapy developement. The aortocaval fistula (ACF) model, first described in dogs almost a century ago, has been adopted in rodents by several groups including ours. Although considered to be a model of high-output heart failure, its long-term renal and cardiac manifestations are similar to those seen in patients with low-output CHF. These include Na+-retention, cardiac hypertrophy and increased activity of both vasoconstrictor/antinatriureticneurohormonal systems and compensatory vasodilating/natriuretic systems. Previous data from our group and others suggest that progression of cardiorenal pathophysiology in this model is largely determined by balance between opposing hormonal forces, as reflected in states of CHF decompensation that are characterized by overactivation of vasoconstrictive/Na+-retaining systems. Thus, ACF serves as a simple, cheap, and reproducible platform to investigate the pathogenesis of CHF and to examine efficacy of new therapeutic approaches. Hereby, we will focus on the neurohormonal, renal, and cardiac manifestations of the ACF model in rats, with special emphasis on our own experience.

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“…By contrast, certain neurohormone‐ or hormone‐secreting cells contain small granules of a wider range of sizes (volume = 0.004–0.065 μm 3 ) and the individual granules comprise one to a few unit granules [32, 33]. This may facilitate the simultaneous secretion of a single type of small peptide hormone together with proportional amounts of other secretory products which can have autocrine, paracrine or systemic effects; in such cells, there also would be some membrane conservation during formation of mature granules.…”

Section: Functional Implicationsmentioning

confidence: 99%

Regulation of secretory granule size by the precise generation and fusion of unit granules

Hammel

Lagunoff

Galli

2010

J Cellular Molecular Medi

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Morphometric evidence derived from studies of mast cells, pancreatic acinar cells and other cell types supports a model in which the post-Golgi processes that generate mature secretory granules can be resolved into three steps: (1) fusion of small, Golgi-derived progranules to produce immature secretory granules which have a highly constrained volume; (2) transformation of such immature granules into mature secretory granules, a process often associated with a reduction in the maturing granule’s volume, as well as changes in the appearance of its content and (3) fusion of secretory granules of the smallest size, termed ‘unit granules’, forming granules whose volumes are multiples of the unit granule’s volume. Mutations which perturb this process can cause significant pathology. For example, Chediak–Higashi syndrome / lysosomal trafficking regulator (CHS)/(Lyst) mutations result in giant secretory granules in a number of cell types in human beings with the Chediak–Higashi syndrome and in ‘beige’ (Lystbg/Lystbg) mice. Analysis of the secretory granules of mast cells and pancreatic acinar cells in Lyst-deficient beige mice suggests that beige mouse secretory granules retain the ability to fuse randomly with other secretory granules no matter what the size of the fusion partners. By contrast, in normal mice, the pattern of granule–granule fusion occurs exclusively by the addition of unit granules, either to each other or to larger granules. The normal pattern of fusion is termed unit addition and the fusion evident in cells with CHS/Lyst mutations is called random addition. The proposed model of secretory granule formation has several implications. For example, in neurosecretory cells, the secretion of small amounts of cargo in granules constrained to a very narrow size increases the precision of the information conveyed by secretion. By contrast, in pancreatic acinar cells and mast cells, large granules composed of multiple unit granules permit the cells to store large amounts of material without requiring the amount of membrane necessary to package the same amount of cargo into small granules. In addition, the formation of mature secretory granules that are multimers of unit granules provides a mechanism for mixing in large granules the contents of unit granules which differ in their content of cargo.

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Evaluation of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Atrial Granules of Rats with Experimental Congestive Heart Failure

Cited by 21 publications

References 27 publications

Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support

Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support

Aortocaval Fistula in Rat: A Unique Model of Volume‐Overload Congestive Heart Failure and Cardiac Hypertrophy

Regulation of secretory granule size by the precise generation and fusion of unit granules

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