Evaluation of autonomic function in children and adolescents with overactive bladder

Gondim, Rhaiana; Gorjão, Julia; Nacif, Ananda; Franco, Israel; Barroso, Ubirajara

doi:10.1590/s1677-5538.ibju.2021.0177

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…NGF may play a role in urinary bladder dysfunction through promoting inflammation, as well as morphological and functional alterations in the sensory and sympathe-tic neurons that innervate the bladder. There is a disruption in the autonomic balance between the sympathetic and parasympathetic neural systems in patients with OAB, as well as less sympathetic activity at the post-voiding instant (17). Several studies have advocated the association between increased levels of NGF in urine and OAB in adult population (6,11,16).…”

Section: Discussionmentioning

confidence: 99%

Could urinary nerve growth factor and bladder wall thickness predict the treatment outcome of children with overactive bladder?

et al. 2022

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Objective: Bladder wall thickness (BWTh) measurements and Nerve Growth Factor (NGF) /creatinine (Cr) values, as noninvasive tools, were found to predict daytime voiding problems in children with overactive bladder (OAB). The goal of this research was to examine if bladder wall thickness together with urine NGF/Cr could be a clinical utility in treatment outcome of OAB in children. Patients and Methods: A total of 60 children with OAB, (Group 1; n=40) and healthy normal controls (Group 2; n=20), aged 6-14 years old were involved in this prospective study. Children were evaluated with detailed history and physical examination, including neurologic examination, and were asked to complete a self-reported questionnaire and a 3-day bladder diary with the aid of their parents. Urofl owmetry was performed in all cases. Urinary nerve growth factor levels were measured by the ELISA and BWTh was measured trans-abdominally by one uro-radiologist specialized in pediatric ultrasonography. Urinary NGF levels were normalized by urinary creatinine levels and compared among all subgroups. Children with OAB received urotherapy as fi rst line treatment at least for three months. 18 children refractory to urotherapy received anticholinergic therapy defi ned as group 3. Results: The median age of the study group was 10 (range 6 to 16). After urotherapy, 22 children had similar BWTh and NGF/Cr values compared to controls. (2.75 ± 1.15; 2.40 ± 1.00 mm; p=0.86 and 1.02 ± 0.10; 0.78 ± 0.15; p=0.12, respectively). After anticholinergic treatment, BWTh levels (2.25 ± 0.90; 2.40 ± 1.00 mm; p=0.94) and NGF/Cr values (0.95 ± 0.10; 0.78 ± 0.15; p=0.42, respectively) had no signifi cantly difference compared to controls (Group 2). In receiver operating characteristic analysis, bladder wall thickness was found to have sensitivity of 85% and specifi city of 84.2% (3,20 AUC ,913; 95 %) and NGF/Cr had sensitivity of 90% and specifi city of 92.1% (1,595; AUC ,947; 95 %) in predicting treatment outcome in children with OAB. Conclusions: Bladder wall thickness measurements and NGF/Cr values, as noninvasive tools, could guide outcomes in the treatment of children with overactive bladder.

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Section: Discussionmentioning

confidence: 99%

Could urinary nerve growth factor and bladder wall thickness predict the treatment outcome of children with overactive bladder?

et al. 2022

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“…Hasta ve kontr ol gr ubunun demogr afik ve biyokimyasal ver iler i. 14 Bu çalışmada literatürle uyumlu şekilde obezitesi olanlarda kabızlık daha yüksek oranda idi. Ek olarak gündüz gaita inkontinansının da daha sık olduğu gösterilmiştir.…”

Section: Tartişma Ve Sonuçunclassified

Obez Çocuklarda Uyku Kalitesi ve İşeme Fonksiyonunun Değerlendirilmesi

Sav

Sungur

Kılıçaslan

et al. 2022

Online Türk Sağlık Bilimleri Dergisi

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Objective: Obesity is an important health problem with the potential to cause secondary diseases in children. In these patients, increased intra-abdominal and intra-vesical pressure leads to changes in voiding physiology. In addition, insulin and glucose metabolism disorders can also affect lower urinary system functions. However, the relationship between obesity and sleep disorders is also known. Materials and Methods: The questionnaire, which was prepared to determine voiding and sleep disorders, was applied to 100 obese pediatric patients aged between 9 and 18 and 100 normal weight healthy individuals in the similar age group. Results: Daytime urinary incontinence was present in 17% of the patient group and 2% of the control group. Nocturnal enuresis was present in 25% of the patient group and 2% of the control group. The frequency of overactive bladder was also higher in the patient group compared to the healthy controls (15% and 5%, respectively; p

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“…OAB is not synonymous with detrusor overactivity, because although detrusor overactivity is a urodynamic diagnosis, OAB is a symptom-based diagnosis (3). OAB is commonly found in children (especially between ages 5-7 years and in boys) and adolescents, affecting around 5-12% of children aged between 5 and 10 years and 0.5% of adolescents up to age 18 years with daytime symptoms (2,4).…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, urgency is usually associated with UI and frequency (1,2). UI is seen in around 14-30% of OAB cases (4,5). UI impairs quality of life (QoL) and negatively affects children's social, behavioral, and emotional well-being.…”

Section: Introductionmentioning

confidence: 99%

The effect of vitamin D deficiency in children with overactive bladder related urinary incontinence

Özçift¹,

Miçooğulları

2022

Int. braz j urol.

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Purpose: Overactive bladder (OAB) is a common syndrome associated with lower urinary tract symptoms (LUTS), especially urinary incontinence in children, which may affect the patient's quality of life (QoL). Vitamin D deficiency has been shown to be associated with OAB syndrome. This study evaluated the relationship between vitamin D status and OAB-related symptoms and QoL in children. Materials and Methods:The study included 52 pediatric patients with OAB-related urinary incontinence and 41 healthy children. LUTS were assessed using the Dysfunctional Voiding and Incontinence Symptoms Score (DVISS) questionnaire, and QoL was assessed using the Pediatric Incontinence Questionnaire (PINQ). Oral vitamin D supplementation was given to patients with OAB with vitamin D deficiency. Urinary symptoms and QoL were evaluated before and after vitamin D supplementation. Results: Vitamin D deficiency was more common in the OAB group (75%) than in the control group (36.6%). Logistic regression analysis revealed that vitamin D status (<20ng/ mL) was a significant predictor of OAB. Both pre-treatment and post-treatment DVISS and PINQ scores showed a positive correlation. After vitamin D supplementation, 8 (23.5%) patients had a complete response and 19 (55.9%) patients had a partial response. Significant improvement in QoL was also achieved. Conclusions: Vitamin D deficiency is more common in children with urinary incontinence and OAB than in healthy children. Although vitamin D deficiency is not routinely evaluated for every patient, it should be evaluated in treatment-resistant OAB cases. Vitamin D supplementation may improve urinary symptoms and QoL in patients with OAB.

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Evaluation of autonomic function in children and adolescents with overactive bladder

Cited by 9 publications

References 19 publications

Could urinary nerve growth factor and bladder wall thickness predict the treatment outcome of children with overactive bladder?

Could urinary nerve growth factor and bladder wall thickness predict the treatment outcome of children with overactive bladder?

Obez Çocuklarda Uyku Kalitesi ve İşeme Fonksiyonunun Değerlendirilmesi

The effect of vitamin D deficiency in children with overactive bladder related urinary incontinence

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