Evaluation of autonomic functions in subclinical hypothyroid and hypothyroid patients

Mahajan, Aarti; Lal, Ram A.; Dhanwal, Dinesh; Jain, Ajay K.; Chowdhury, Veena

doi:10.4103/2230-8210.111642

Cited by 22 publications

(27 citation statements)

References 27 publications

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“…Çelik et al proved that HRV and heart rate (HR) turbulence was reduced in the patient group, and the cardiac autonomic functions did not improve effectively with levothyroxine treatment (7,19). In a previous study by Mahajan et al, it was also demonstrated that autonomic dysfunction may be seen in both subclinical and frank hypothyroidism (5).…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of SH varies between 1% and 10% and increases with age (4). Hypothyroidism is associated with various cardiac pathologies, including impaired cardiac contractility, decreased cardiac output, increased systemic vascular resistance and cardiac electrical abnormalities (5). Electrocardiographic changes, including bradycardia, low voltage and varying degrees of heart block are commonly observed in hypothyroid patients.…”

Section: Introductionmentioning

confidence: 99%

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Impact of subclinical hypothyroidism on frequency of premature ventricular contractions in elderly patients without structural heart disease

Tak¹,

Ekizler²

2019

tjgeri

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of subclinical hypothyroidism on frequency of premature ventricular contractions in elderly patients without structural heart disease

Tak¹,

Ekizler²

2019

tjgeri

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“…The previous study done by Mahajan et al . [ 8 ] also suggested that autonomic dysfunction may be seen in both subclinical and frank hypothyroidisms. [ 8 ] Inukai et al .…”

Section: Discussionmentioning

confidence: 99%

“…[ 8 ] also suggested that autonomic dysfunction may be seen in both subclinical and frank hypothyroidisms. [ 8 ] Inukai et al . showed that hypothyroidism is associated with increased sympathetic input to the heart.…”

Section: Discussionmentioning

confidence: 99%

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Cardiac autonomic function and vascular profile in subclinical hypothyroidism: Increased beat-to-beat QT variability

Kalra

Yeragani

Kumar

2016

Indian J Endocr Metab

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Background:Patients with subclinical hypothyroidism (SH) may have higher incidence of coronary heart disease and autonomic dysfunction.Design of the Study:Prospective case control study.Aim and Objectives:To evaluate beat-to-beat QT variability and vascular stiffness in patients with SH compared to normal controls.Materials and Methods:We compared linear and nonlinear measures of cardiac repolarization liability using beat-to-beat QT intervals derived from the surface electrocardiogram during supine posture and vascular indices including pulse wave velocity and ankle-brachial index (ABI) during supine posture between female patients with SH and age- and sex-matched normal controls. Spectral analysis was done at very low frequency (LF) (0.003–0.04 Hz), Low frequency (LF) (0.04–0.15 Hz), and high frequency (HF) (0.15–0.4 Hz). The HF represents vagal regulation (parasympathetic) and LF represents both parasympathetic and sympathetic regulation.Results:We recruited 58 women with a mean age of 31.83 ± 8.9 years and 49 controls with mean age of 32.4 ± 9.9 years (P = NS). QT variability index (QTvi) was higher in cases compared to controls (P = 0.01). The ratio of LF/HF of R-R interval which is an index of sympathovagal tone was significantly more in cases compared to controls (P = 0.02). The difference in the left minus the right ABI was significant between cases and controls (P = 0.03).Conclusions:The cases had lower parasympathetic activity as compared to controls, and there was a predominance of sympathetic activity in cases. QTvi may be an important noninvasive tool in this group of patients to study the risk of cardiovascular mortality.

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Impact of gender on in‐hospital outcomes in patients with Takotsubo syndrome: A nationwide analysis from 2006 to 2014

Lemor

Ramos‐Rodriguez

Villa

et al. 2018

Clinical Cardiology

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Background: Takotsubo syndrome (TTS) is characterized by acute, transient systolic dysfunction of the left ventricle not attributed to coronary artery disease (CAD).Hypothesis: There are differences in hospital outcomes in patients admitted with TTS based on their gender. Methods:The National Inpatient Sample database was searched for patients admitted with a principal diagnosis of TTS from 2006 to 2014 using the ICD9-CM code 429.83. Using Pearson's χ 2 and Student's t test analyses, the P-value was calculated for differences among baseline characteristics of patients. Multivariate regression models were then created to adjust for potential confounders.Results: A total of 39 662 admissions with TTS were identified, 91.7% female and 8.3% male with mean age of 66.5 and 61.6 years, respectively. The incidence of TTS increased progressively from 2006 to 2014. Female patients were more likely to have hypertension, hypothyroidism, or depression. Males were more likely to use tobacco, or have known CAD. Males had almost 4-fold higher probability of in-hospital mortality compared to females (3.7% vs 1.1%; P<0.001). Certain complications including cardiogenic shock, ventricular fibrillation/tachycardia, and acute kidney injury were more common in males.Conclusions: There are distinct gender differences in clinical characteristics of patients admitted with TTS. Although TTS is more common in females, it is associated with higher morbidity and mortality in males.

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Evaluation of autonomic functions in subclinical hypothyroid and hypothyroid patients

Cited by 22 publications

References 27 publications

Impact of subclinical hypothyroidism on frequency of premature ventricular contractions in elderly patients without structural heart disease

Impact of subclinical hypothyroidism on frequency of premature ventricular contractions in elderly patients without structural heart disease

Cardiac autonomic function and vascular profile in subclinical hypothyroidism: Increased beat-to-beat QT variability

Impact of gender on in‐hospital outcomes in patients with Takotsubo syndrome: A nationwide analysis from 2006 to 2014

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