Evaluation of baseline contractile reserve vs dyssynchrony as a predictor of functional improvement and long term outcome after resynchronization pacing therapy: A radionuclide stress study

Abstract

In patients with left ventricular dysfunction and baseline dyssynchrony as assessed by ERNA, evaluation of mCR during LDD may help predicting functional improvement and selecting potential responders to CRT.

Does presence of left ventricular contractile reserve improve response to cardiac resynchronization therapy? An updated meta-analysis

“…Studies have used a variety of different imaging modalities and techniques to measure contractile reserve [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Interpretation of studies is difficult due to multiple different definitions of response; these include clinical assessment of functional capacity (New York Heart Association Class), echocardiographic measures of left ventricular remodeling/performance (LV size, volume or ejection fraction) and prognostic markers (heart failure admissions, freedom from heart transplant).…”

Dyssynchronous! Remediable?

“…2 These investigators set out to understand the contribution of left ventricular contractile reserve (LVCR), measured using radionuclide ventriculography (RVG), to the prediction of CRT outcomes. Although they did not exclusively study patients with ischemic cardiomyopathy, the context provided by the inclusion of patients with non-ischemic etiology actually provides additive value.…”