Evaluation of behavioral disinhibition in P/NP and HAD1/LAD1 Rats

Steinmetz, Joseph E.; Blankenship, Matthew R.; Green, John T.; Smith, Gordon B.; Finn, Peter R.

doi:10.1016/s0278-5846(00)00122-6

Cited by 13 publications

(11 citation statements)

References 17 publications

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“…Evidence from human prospective studies suggests that pathological levels of impulsivity may not only be a consequence of alcohol use, but could pre-date the development of alcohol use disorder (Caspi et al, 1996; Dawes et al, 1997). In line with these observations in humans, increased levels of impulsive behavior have been observed in alcohol-naïve rats (Steinmetz et al, 2000; Wilhelm and Mitchell, 2008), as well as in certain mouse lines (Logue et al, 1998; Oberlin and Grahame, 2009; Gubner et al, 2010) that are genetically predisposed to show a high preference of alcohol consumption. However, whether genetically determined poor executive control coincides with vulnerability to crucial stages of alcohol abuse, such as motivation to take and seek alcohol, and reinstatement of alcohol seeking after extinction, has not been investigated.…”

Section: Introductionmentioning

confidence: 61%

Enhanced alcohol self-administration and reinstatement in a highly impulsive, inattentive recombinant inbred mouse strain

Loos

Staal

Smit

et al. 2013

Front. Behav. Neurosci.

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Deficits in executive control have frequently been associated with alcohol use disorder. Here we investigated to what extent pre-existing genetically encoded levels of impulsive/inattentive behavior associate with motivation to take alcohol and vulnerability to cue-induced reinstatement of alcohol seeking in an operant self-administration paradigm. We took advantage of BXD16, a recombinant inbred strain previously shown to have enhanced impulsivity and poor attentional control. We compared BXD16 with C57BL/6J mice in a simple choice reaction time task (SCRTT) and confirmed its impulsive/inattentive phenotype. BXD16 mice were less active in a novel open field (OF), and were equally active in an automated home cage environment, showing that increased impulsive responding of BXD16 mice could not be explained by enhanced general activity compared to C57BL/6J mice. After training in a sucrose/alcohol fading self-administration procedure, BXD16 showed increased motivation to earn 10% alcohol solution, both under fixed ratio (FR1) and progressive ratio (PR2) schedules of reinforcement. Responding on the active lever readily decreased during extinction training with no apparent differences between strains. However, upon re-exposure to alcohol-associated cues, alcohol seeking was reinstated to a larger extent in BXD16 than in C57BL/6J mice. Although further studies are needed to determine whether impulsivity/inattention and alcohol seeking depend on common or separate genetic loci, these data show that in mice enhanced impulsivity coincides with increased motivation to take alcohol, as well as relapse vulnerability.

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Section: Introductionmentioning

confidence: 61%

Enhanced alcohol self-administration and reinstatement in a highly impulsive, inattentive recombinant inbred mouse strain

Loos

Staal

Smit

et al. 2013

Front. Behav. Neurosci.

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“…No difference, however, was observed in the number of hits, misses, or false alarms committed by STD-RHI2 and STDRLO2 mice, suggesting that animals were equally able to associate cues with the need to suppress responding. In addition, an inability to adequately suppress motor responses has previously been interpreted as heightened impulsivity (Steinmetz et al, 2000). Despite significant differences in pre-cue responding, there were no line differences in efficiency.…”

Section: Discussionmentioning

confidence: 95%

“…However, Schweinsburg et al (2004) saw no effect of a family history of alcohol abuse on the ability of children to inhibit responding in a Go ⁄ No-go task (children were instructed to press a button as quickly as possible following presentation of some cues, but to withhold responding when presented with others). Steinmetz et al (2000) used a differential reinforcement of low rates of responding (DRL) task, in which reinforcers are earned only when responses are spaced apart by a minimum preset time, to compare differences between alcohol-preferring (P), alcohol nonpreferring (NP), and high alcohol drinking (HAD) or low alcohol drinking (LAD) rats. No rat line differences were observed on the task.…”

mentioning

confidence: 99%

Mouse Lines Selected for Alcohol Consumption Differ on Certain Measures of Impulsivity

Wilhelm

Reeves

Phillips

et al. 2007

Alcoholism Clin & Exp Res

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“…In addition, they showed deficits on a DRL task, in which they had to learn to suppress bar pressing when training was shifted to require a delay in bar pressing to receive a sugar pellet reward. This led the researchers to suggest that P rats are ‘a good model of disinhibitory processes associated with familial and personality-risk for alcoholism’ (Steinmetz et al 2000). Research using the high alcohol drinking (HAD1 and HAD2) and low alcohol drinking (LAD1 and LAD2) rat lines indicate that animals selected for high alcohol consumption also exhibit higher levels of delay aversion measured using a delay discounting task (Wilhelm & Mitchell 2008).…”

Section: The Relationship Between Impulsivity and Alcohol Usementioning

confidence: 99%

REVIEW: Understanding the construct of impulsivity and its relationship to alcohol use disorders

et al. 2010

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There are well-established links between impulsivity and alcohol use in humans and other model organisms; however, the etiological nature of these associations remains unclear. This is likely due, in part, to the heterogeneous nature of the construct of impulsivity. Many different measures of impulsivity have been employed in human studies, using both questionnaire and laboratory-based tasks. Animal studies also use multiple tasks to assess the construct of impulsivity. In both human and animal studies, different measures of impulsivity often show little correlation and are differentially related to outcome, suggesting that the impulsivity construct may actually consist of a number of more homogeneous (and potentially more meaningful) subfacets. Here, we provide an overview of the different measures of impulsivity used across human and animal studies, evidence that the construct of impulsivity may be better studied in the context of more meaningful subfacets, and recommendations for how research in this direction may provide for better consilience between human and animal studies of the connection between impulsivity and alcohol use.

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Evaluation of behavioral disinhibition in P/NP and HAD1/LAD1 Rats

Cited by 13 publications

References 17 publications

Enhanced alcohol self-administration and reinstatement in a highly impulsive, inattentive recombinant inbred mouse strain

Enhanced alcohol self-administration and reinstatement in a highly impulsive, inattentive recombinant inbred mouse strain

Mouse Lines Selected for Alcohol Consumption Differ on Certain Measures of Impulsivity

REVIEW: Understanding the construct of impulsivity and its relationship to alcohol use disorders

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