EVALUATION OF BENZENE EXPOSURE IN CHILDREN LIVING IN CAMPANIA (ITALY) BY URINARY<i>trans,trans</i>-MUCONIC ACID ASSAY

Amodio-Cocchieri, Renata; Prete, U Del; Cirillo, Teresa; Agozzino, Erminia; Scarano, G.

doi:10.1080/15287390151126388

Cited by 22 publications

(11 citation statements)

References 30 publications

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“…Among them, urinary tt- MA is increasingly recognized as a reliable and relatively convenient biomarker [14], [15], [16]. The compound tt- MA is an open-ring (nonphenolic) metabolite of benzene [17].…”

Section: Introductionmentioning

confidence: 99%

Urinary Trans, Trans -Muconic Acid is Not a Reliable Biomarker for Low-level Environmental and Occupational Benzene Exposures

Jalai

Ramezani

Ebrahimpour

2017

Safety and Health at Work

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BackgroundBenzene is a known occupational and environmental pollutant. Its urinary metabolite trans, trans-muconic acid (tt-MA) has been introduced by some environmental and occupational health regulatory associations as a biological index for the assessment of benzene exposure; however, recently, doubts have been raised about the specificity of tt-MA for low-level benzene exposures. In the present study, we investigated the association between urinary levels of tt-MA and inhalational exposure to benzene in different exposure groups.MethodsBenzene exposure was assessed by personal air sampling. Collected benzene on charcoal tube was extracted by carbon disulfide and determined by a gas chromatograph (gas chromatography with a flame ionization detector). Urinary tt-MA was extracted by a strong anion-exchange column and determined with high-performance liquid chromatography–UV.ResultsUrinary levels of tt-MA in intensive benzene exposure groups (chemical workers and police officers) were significantly higher than other groups (urban and rural residents), but its levels in the last two groups with significant different exposure levels (mean = 0.081 ppm and 0.019 ppm, respectively) showed no significant difference (mean = 388 μg/g creatinine and 282 μg/g, respectively; p < 0.05). Before work shift, urine samples of workers and police officers showed a high amount of tt-MA and its levels in rural residents’ samples were not zero.ConclusionOur results suggest that tt-MA may not be a reliable biomarker for monitoring low-level (below 0.5 ppm) benzene exposures.

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Section: Introductionmentioning

confidence: 99%

Urinary Trans, Trans -Muconic Acid is Not a Reliable Biomarker for Low-level Environmental and Occupational Benzene Exposures

Jalai

Ramezani

Ebrahimpour

2017

Safety and Health at Work

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“…Weaver et al (1996) conducted a pilot study to evaluate the feasibility of using trans,trans-muconic acid (MA) as a biomarker for environmental benzene exposure in urban children. In a recent study conducted on 144 children living in Italy, Amodio-Cocchieri et al (2001) also used MA as a biomarker for environmental exposure. Measurements of benzene biomarkers, which can provide information on individual variation in absorption and 5 metabolism and, thus susceptibility to adverse health effects, appear to be useful in the case of benzene.…”

Section: Introductionmentioning

confidence: 99%

Environmental benzene exposure assessment for parent–child pairs in Rouen, France

Kouniali

Cicolella

Gonzalez-Flesca

et al. 2003

Science of The Total Environment

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There is a lack of data on environmental benzene exposure in children. In this study, we compared personal benzene exposure and inhalation uptake in a group of children to those of their parents. We also compared levels of urinary benzene metabolites, trans,trans-muconic acid (MA) and hydroquinone (HQ), for those two groups, and assessed the correlation between personal benzene exposure and urinary MA and HQ concentrations. The study was performed on 21, 2-3-year-old children and their parents recruited on a voluntary basis among non-smokers from the three largest day-care centers of the town of Rouen in France. Average benzene concentrations were measured over 5 consecutive days with diffusive samplers. The following simultaneous measurements were carried out: personal exposure of the parents, concentrations inside and outside the day care centers, and inside the volunteer's bedrooms. Morning and evening urine samples were collected during the same period. Benzene personal exposure levels were 14.4+/-7.7 microg/m(3) and 11.09+/-6.15 microg/m(3) in parents and children, respectively. Benzene inhalation uptake estimates were 2.51+/-1.23 microg/kg/day in the group of parents and 5.68+/-3.17 microg/kg/day in the group of children. Detectable levels of MA and HQ were found in 85% and 100% of the samples, respectively. Intra-individual variation of urinary MA and HQ concentrations expressed as a coefficient of variation (CV) ranged from 63 to 232% and from 13 to 144%, respectively. Mean values of MA and HQ (in mg/g creatinine) were 1.6- and 1.8-fold higher in the group of children than in the group of parents (P=0.008 and P<0.0001, respectively). Significant correlations between metabolites levels and benzene were not found.

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“…The mean or median urinary ttMA concentrations range from 30 µg/g creatinine to 300 µg/g creatinine among non-occupationally benzene exposed populations (Amodio-Cocchieri et al., 2001; Fustinoni et al., 2005b; Kim et al., 2006a; Melikian et al., 2002; Navasumrit et al., 2005; Pezzagno et al., 1999; Qu et al., 2000; Scherer et al., 1998; Waidyanatha et al., 2004; Weaver et al., 2000). Smoking habits significantly influence ttMA levels (Buratti et al., 1996; Fustinoni et al., 2005b; Ghittori et al., 1995, 1996; Lauwerys et al., 1994; Lee et al., 1993; Melikian et al., 1993, 1994; Ong et al., 1994; Ruppert et al., 1995, 1997).…”

Section: Biomarkers/analytical Methodologymentioning

confidence: 99%

“…On a group basis, urinary ttMA concentrations allow discrimination between smokers and non-smokers. Individuals living near or being in areas with high traffic density can have slightly higher urinary ttMA levels (Amodio-Cocchieri et al., 2001; Scherer et al., 1995; Weaver et al., 1996). In contrast, other researchers found that traffic density did not result in significant differences in urinary levels of ttMA among children from urban and rural areas (Barbieri et al .…”

Section: Biomarkers/analytical Methodologymentioning

confidence: 99%

The use of biomonitoring data in exposure and human health risk assessment: benzene case study

Arnold

Angerer

Boogaard

et al. 2013

Critical Reviews in Toxicology

130

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A framework of “Common Criteria” (i.e. a series of questions) has been developed to inform the use and evaluation of biomonitoring data in the context of human exposure and risk assessment. The data-rich chemical benzene was selected for use in a case study to assess whether refinement of the Common Criteria framework was necessary, and to gain additional perspective on approaches for integrating biomonitoring data into a risk-based context. The available data for benzene satisfied most of the Common Criteria and allowed for a risk-based evaluation of the benzene biomonitoring data. In general, biomarker (blood benzene, urinary benzene and urinary S-phenylmercapturic acid) central tendency (i.e. mean, median and geometric mean) concentrations for non-smokers are at or below the predicted blood or urine concentrations that would correspond to exposure at the US Environmental Protection Agency reference concentration (30 µg/m3), but greater than blood or urine concentrations relating to the air concentration at the 1 × 10−5 excess cancer risk (2.9 µg/m3). Smokers clearly have higher levels of benzene exposure, and biomarker levels of benzene for non-smokers are generally consistent with ambient air monitoring results. While some biomarkers of benzene are specific indicators of exposure, the interpretation of benzene biomonitoring levels in a health-risk context are complicated by issues associated with short half-lives and gaps in knowledge regarding the relationship between the biomarkers and subsequent toxic effects.

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EVALUATION OF BENZENE EXPOSURE IN CHILDREN LIVING IN CAMPANIA (ITALY) BY URINARYtrans,trans-MUCONIC ACID ASSAY

Cited by 22 publications

References 30 publications

Urinary Trans, Trans -Muconic Acid is Not a Reliable Biomarker for Low-level Environmental and Occupational Benzene Exposures

Urinary Trans, Trans -Muconic Acid is Not a Reliable Biomarker for Low-level Environmental and Occupational Benzene Exposures

Environmental benzene exposure assessment for parent–child pairs in Rouen, France

The use of biomonitoring data in exposure and human health risk assessment: benzene case study

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