Evaluation of Bioactivities of Morinda Tinctoria Leaves Extract for Pharmacological Applications.

Abstract

Objective: The present study was aimed to prepare Morinda tinctoria leaves extracts with the different solvent system and to evaluate the bioactivities. Methods:The extracts of M. tinctoria were qualitatively analyzed for the primary phytochemical content. The functional groups of extract were determined by Fourier-transform infrared spectroscopy (FT-IR) analysis. The antimicrobial properties were determined by plate assays. The antioxidant and in vitro antiinflammatory properties and membrane stabilizing nature of aqueous extract of M. tinctoria (AEM) were measured using a spectrophotometer. Results:The aqueous, ethanolic, and acetone extracts of M. tinctoria were prepared. AEM contains quinones, steroids, terpenoids, phenols, glycosides, and tannins. FTIR result showed that AEM comprises of alkyl halides, 1°, 2° amines, aromatics, aliphatic amines, alcohols, carboxylic acids, esters, ethers, and alkanes, saturated aliphatic, and phenolic groups. The antimicrobial property of M. tinctoria varied based on the solvent used for the extraction. About 86.90±0.36, 78.58±0.13, and 80.33±0.09% of total antioxidant capacity, reducing power, and hydrogen peroxide scavenging activity were observed in AEM, respectively. The 1, 1-diphenyl 2-picrylhyorazyl and 2, 2-Azinobis-(3 ethylbenzothiazoline-6-sulfonic acids) assay results indicated 85.20±0.50 and 52.41±0.60% of free radical scavenging activity in AEM. The protease activity (44.10±0.26%) and protein degradation (44.38±0.58%) were proscribed by AEM. AEM prevents 69.36±0.20% of cell lysis. Conclusion:The results revealed that the AEM leaves were harmless and enriched with potent bioactive principles, which is further used for food and pharmacological applications.

Phytochemical and pharmacological properties of Morinda tinctoria – A review

“…The phytochemitry of the plant was also analyzed and various constituents like quinoes, steroids, terpenoids and glycosides were eluted using FTIR. The ethanol extract of the leaves showed esters and carboxylic acids and alkenes [4].…”

“…The ethanol extract of the leaves of the plant were used to test the activity and the results showed a 85% inhibition of free radicals with almost 8% total antioxidant capacity. In H2O2 method, 78% of the activity was shown by the extract [4] .…”

“…The results showed 44% degradation of proteins and 45% of protease activity and the extract prevented the break down of cells by almost 70%. Therefore, it can be con irmed that the ethanol extract of the leaves showed an anti-in lammatory property [4].…”

A Systematic Comparative Study of Morinda Tinctoria and Vitex Negundo for their Anti-Ulcerogenic Potential

“…it may be utilized to treat a variety of ailments. Researchers discovered that the leaf, root, and fruit extracts of M.Tinctoria had a variety of medicinal qualities, including ulcerfighting properties (Mathivanan et al, 2006;Bagavan et al, 2008;Vadivu et al, 2008;Sahoo et al, 2009;Sivaraman & Muralidharan, 2010;Sivakumar et al, 2018;Rex Jeya Rajkumar et al, 2018). Nirgundi, Sambhalu, or monk's paper are all names for Vitex negundo L. It grows in wet locations, often along river banks, in India up to a height of 1500 gigameters as well as in the Mediterranean and Central Asian regions.…”

Optical and biomedical applications of eco-friendly biosynthesized silver nano spheres using zingiber officinale root extract

“…Several reports have appeared on synthesis of silver NPs by plant extracts. Some of them are using: Radish [7], Pinus desiflora (red pine) [8], ginko, persimmon, mokryeon, oriental plane, Cycas leaf [9], drumstick leaf [10], Shorea tumbuggaia stem bark [11], Cinnamon [12], papaya [13], biskhapra roots [14], Jatropha curcas latex [15], jack fruit leaf [16], big-sage [17], coriander leaf [18] and wild croton leaf [19] etc.…”