Evaluation of Biocompatibility of PLA/PHB/TPS Polymer Scaffolds with Different Additives of ATBC and OLA Plasticizers

Trebuňová, Marianna; Petroušková, Patrícia; Balogová, Alena Findrik; Ižaríková, Gabriela; Horňak, Peter; Bačenková, Darina; Demeterová, Jana; Živčák, Jozef

doi:10.3390/jfb14080412

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…Table 4 summarizes studies that use different methods to obtain scaffolds with PHB for BTE. 7,[71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86] Similarly, a compilation of different investigations was carried out where the geometry (Table 5) and manufacturing technique (Figure 3) of the PHB scaffolds were compared for skin, nerve, cartilage, and bone applications.…”

Section: Cartilage Tissue Engineeringmentioning

confidence: 99%

The role of poly(3‐hydroxybutyrate)‐based derivatives in skin, nerve, cartilage, and bone tissue engineering applications—An updated review

Reyna‐Urrutia,

Leyva‐Gómez,

Ríos

et al. 2024

Polymers for Advanced Techs

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Poly(3‐hydroxybutyrate) (PHB) has gained significant attention in the realm of medical applications in recent years. This acceptability is rooted in its bioactive properties and remarkable biocompatibility, as the degradation products exhibit negligible cytotoxicity. PHB boasts commendable mechanical resilience, distinguishing it from other polymers commonly used in tissue engineering. Using PHB in fabricating 3D scaffolds serves various objectives, often involving a combination with other polymers, ceramics, fibers, or regenerative factors. This distinctive approach sets it apart, leading to the creation of composite biomaterials. These incorporated materials enhance characteristics such as brittleness, hydrophobicity, degradation rate, and biocompatibility, within the composite. This review delves into the diverse roles that PHB, its alloys, and its compounds play in the engineering of skin, nerve, cartilage, and bone tissues. We explain these roles by highlighting key methodologies for crafting 3D tissue scaffolds with widely adopted techniques, including polymeric sponges, electrospinning, and salt leaching.

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Section: Cartilage Tissue Engineeringmentioning

confidence: 99%

The role of poly(3‐hydroxybutyrate)‐based derivatives in skin, nerve, cartilage, and bone tissue engineering applications—An updated review

Reyna‐Urrutia,

Leyva‐Gómez,

Ríos

et al. 2024

Polymers for Advanced Techs

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“…Trebu ňová et al tested the composite material PLA/PHB for cultivation and cytotoxicity while evaluating the most optimal ratio of individual components for the mentioned parameters. They observed that the composite material did not show any significant signs of cytotoxicity [152].…”

Section: Biocompatible Synthetic Scaffoldmentioning

confidence: 99%

Human Chondrocytes, Metabolism of Articular Cartilage, and Strategies for Application to Tissue Engineering

Bačenková,

Trebuňová,

Demeterová

et al. 2023

IJMS

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Hyaline cartilage, which is characterized by the absence of vascularization and innervation, has minimal self-repair potential in case of damage and defect formation in the chondral layer. Chondrocytes are specialized cells that ensure the synthesis of extracellular matrix components, namely type II collagen and aggregen. On their surface, they express integrins CD44, α1β1, α3β1, α5β1, α10β1, αVβ1, αVβ3, and αVβ5, which are also collagen-binding components of the extracellular matrix. This article aims to contribute to solving the problem of the possible repair of chondral defects through unique methods of tissue engineering, as well as the process of pathological events in articular cartilage. In vitro cell culture models used for hyaline cartilage repair could bring about advanced possibilities. Currently, there are several variants of the combination of natural and synthetic polymers and chondrocytes. In a three-dimensional environment, chondrocytes retain their production capacity. In the case of mesenchymal stromal cells, their favorable ability is to differentiate into a chondrogenic lineage in a three-dimensional culture.

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“…Starch can be used as nanofillers in the form of starch nanocrystals, preserving its native crystalline form or as a matrix, in the form of thermoplastic matrix when processed with water and/or plasticizer, destructuring its granules [ 15 ]. In the recent years, blends of PLA and thermoplastic starch (TPS) have been studied as environmentally friendly materials of great interest for food packaging and biomedical applications [ 16 , 17 , 18 ]. However, the major drawback of processing PLA blends through simple physical blending is their immiscibility, poor compatibility, and the weak interfacial bonding of the blend components [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Thermally-Activated Shape Memory Behavior of Biodegradable Blends Based on Plasticized PLA and Thermoplastic Starch

Sessini,

Salaris,

Oliver-Cuenca

et al. 2024

Polymers

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Biodegradable blends based on plasticized poly(lactic acid) PLA and thermoplastic starch (TPS) have been obtained. The influence of the PLA plasticizer as a compatibility agent has been studied by using two different plasticizers such as neat oligomeric lactic acid (OLA) and functionalized with maleic acid (mOLA). In particular, the morphological, thermal, and mechanical properties have been studied as well as the shape memory ability of the melt-processed materials. Therefore, the influence of the interaction between different plasticizers and the PLA matrix as well as the compatibility between the two polymeric phases on the thermally-activated shape memory properties have been studied. It is very interesting to use the same additive able to act as both plasticizer and compatibilizer, decreasing the glass transition temperature of PLA to a temperature close to the physiological one, obtaining a material suitable for potential biomedical applications. In particular, we obtain that OLA-plasticized blend (oPLA/TPS) show very good thermally-activated capability at 45 °C and 50% deformation, while the blend obtained by using maleic OLA (moPLA/TPS) did not show shape memory behavior at 45 °C and 50% deformation. This fact is due to their morphological changes and the loss of two well-distinguished phases, one acting as fixed phase and the other one acting as switching phase to typically obtain shape memory response. Therefore, the thermally-activated shape memory results show that it is very important to make a balance between plasticizer and compatibilizer, considering the need of two well-established phases to obtain shape memory response.

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Evaluation of Biocompatibility of PLA/PHB/TPS Polymer Scaffolds with Different Additives of ATBC and OLA Plasticizers

Cited by 6 publications

References 32 publications

The role of poly(3‐hydroxybutyrate)‐based derivatives in skin, nerve, cartilage, and bone tissue engineering applications—An updated review

The role of poly(3‐hydroxybutyrate)‐based derivatives in skin, nerve, cartilage, and bone tissue engineering applications—An updated review

Human Chondrocytes, Metabolism of Articular Cartilage, and Strategies for Application to Tissue Engineering

Thermally-Activated Shape Memory Behavior of Biodegradable Blends Based on Plasticized PLA and Thermoplastic Starch

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