Evaluation of Biocompatible Materials

Bruck, Stephen D.; Rabin, Sheldon; Ferguson, Roger J.

doi:10.3109/10731197309118873

Cited by 35 publications

(11 citation statements)

References 12 publications

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“…Preliminary data suggest that an equilibrium water uptake of about 65-75% by weight and a thickness of about 5 p are needed for optimum blood compatibility. 11, 14 These results are similar to those that were observed on nongrafted polyacrylamide hydrogels and lend further support to the role of the degree of swelling, porosity, permeability, and very likcly to the effect of the quasi-organized water structure of the hydrogels prior to contact with body fluids. Depending on the chemical nature of the substrate polymer, these grafted hydrogels can be sterilized with steam in an autoclave.…”

Section: Surface Grafting Of Hydrogelssupporting

confidence: 76%

Aspects of three types of hydrogels for biomedical applications

Bruck¹

1973

J. Biomed. Mater. Res.

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132

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SummarySome of the chemical and physical properties of three different hydrogels are analyzed as they relate to biological compatibility. The importance of the permeability and diffusion coefficients, porosity, and the possible role of quasiorganized water within the hydrogels are emphasized. It is suggested that the biological environment with its dissolved components such as ions, proteins, carbohydrates, lipids, and enzymes will influence the ultimate biological performance of hydrogels. This biological performance will depend not only on the hydrophilicity of the system but on numerous other parameters including the chemical composition, types and number of crosslinks, presence of functional groups, quasi-organized water structure, porosity, and the thermodynamic interaction parameters between the components of the biological environment and the gel. It is suggested that the presence of anionic gorups on certain synthetic hydrogel surfaces may be not, essential for blood compatibility, provided that such materials are carefully distinguished from other hydrophilic gels.

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Section: Surface Grafting Of Hydrogelssupporting

confidence: 76%

Aspects of three types of hydrogels for biomedical applications

Bruck¹

1973

J. Biomed. Mater. Res.

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132

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“…Covalent grafting of polymer surfaces with hydrogels, e. g., acrylamide, poly(hydroxyethyl methacrylate), etc., enhances blood compatibility [89,[102][103][104]. The biological performance of the grafted hydrogels seems to be related to the extent of protein adsorptiondesorption, and/or conformational and configurational changes, and thus to the subsequent interaction with blood elements, especially the platelets [103].…”

Section: Polymer Surface Modification and Blood Compatibilitymentioning

confidence: 99%

“…It is believed that blood compatibility of LTI carbons is associated with the ability of these materials to maintain a nondenatured layer of protein at the carbon-blood interface, which prevents the sequence of reactions leading to thrombus formation [102].…”

Section: Polymer Surface Modification and Blood Compatibilitymentioning

confidence: 99%

“…The intrinsic coagulation process occurs within the blood itself [101], e. g. on the surface of aggregating platelets, and can be initiated by contact of circulating blood components with the foreign surface [87,89,95,[102][103][104][105][106][107][108]. Exposure of blood to foreign surfaces, leads to a rapid adsorption of plasma proteins, mainly fibrinogen, from the blood onto the material surface.…”

Section: Blood-polymer Compatibilitymentioning

confidence: 99%

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Selected topics in biomedical polyurethanes. A review

Gogolewski

1989

Colloid & Polymer Sci

224

140

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“…The overall blood compatibility of these elastomers is fairly good but it is affected by relatively minor changes in the chemical structure and by the type of coupling agent used in the synthesis. 17 Among non-polymeric materials certain outgassed, smooth, isotropic carbons deposited a t low temperatures (so-called LTI carbons)…”

Section: Typical Materialsmentioning

confidence: 99%

Macromolecular aspects of biocompatible materials—a review

Bruck

1972

J. Biomed. Mater. Res.

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SummaryThis paper is limited chiefly to the question of blood compatibility and will not cover areas such as dental applications and mechanical support prostheses. The demand for blood compatible materials has become important for cardiac and pulmonary assist devices and artificial hearts. Since the second World War, a larger number of synthetic materials became available ranging from elastomeric to hard, hydrophobic to hydrophilic systems, but almost all of these were developed for large-scale commercial end-use where the presence of small quantities of impurities, traces of catalysts, plasticizers, etc., is not too critical. For medical implants, it is necessary to prepare the appropriate polymers in the chemically pure state. The ultimate goal is the fabrication of practical, economical, and working devices. This goal demands that the material not only be compatible with blood, but also be able to perform distinct mechanical and physico-chemical functions or be useful for the isolation of implantable prostheses from body fluids.

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Evaluation of Biocompatible Materials

Cited by 35 publications

References 12 publications

Aspects of three types of hydrogels for biomedical applications

Aspects of three types of hydrogels for biomedical applications

Selected topics in biomedical polyurethanes. A review

Macromolecular aspects of biocompatible materials—a review

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