Evaluation of biofilm formation in the presence of saliva on poly(ethylene glycol)deposited titanium

Abstract

Titanium (Ti) is widely used for oral cavity biomedical devices. However, because it penetrates the mucosa and exists partially external to the tissue, it sometimes induces tissue inflammation, minor infection, or peri-implantitis due to oral bacteria after implantation and causes serious consequences. We have previously shown that poly(ethylene glycol) (PEG)-electrodeposited Ti inhibits bacterial adhesion and biofilm formation. However, the effect of the PEG coating in body fluid is still unclear. In this study, we investigated bacterial colony morphology and biofilm formation on PEG-electrodeposited Ti in comparison with untreated Ti in the presence of saliva. After 48 h incubation, Streptococcus mutans biofilms adhered on the untreated Ti were rigid and cohesive, while those on the PEG-electrodeposited were loose and were easily washed off. These results indicate electrodeposited-PEG layers inhibit the biofilm formation on Ti in the presence of saliva.

Antimicrobial dental implant functionalization strategies —A systematic review

“…Some polymeric surfaces consist of hydrophilic, highly hydrated, non-charged surfaces to reduce any surface interactions. Dextran and polyethylene glycol (PEG) surfaces have been shown to be effective in suppressing protein adhesion, platelet adhesion, bacterial adhesion and biofilm formation of oral relevant pathogens, such as S. aureus, S. sanguinis, L. salivarius S. mutans and S.gordonii 29,96,[101][102][103]107) . Lignin, a complex, amorphous organic polymer found in plant tissues, exhibits antibacterial activity against S. aureus, P. aeruginosa and C. famata 51) .…”

Surface Characterization of Electro-Assisted Titanium Implants: A Multi-Technique Approach

“…Finally, they evaluated the biofilm formation, in the presence of saliva, on PEG-deposited titanium. The thickness of the immobilized PEG layer, measured by ellipsometry [89], was equal to 2.49 ± 0.39 nm.…”

Lectin‐Functionalized Polyethylene Glycol for Relief of Mucosal Dryness

“…Polyethylene glycol (PEG) is a highly hydrophilic polymer which hydrates and lubricates very effectively when grafted to surfaces. [21,22] PEG chains are polyether compounds of repeating ethylene glycol units. [23] PEG is a widely applied polymer in the food, cosmetic, and pharmaceutical industries, with a long and positive safety track record.…”