Evaluation of BioFire Respiratory Panel 2
            <i>plus</i>
            for Detection of Bordetella pertussis in Nasopharyngeal Swab Specimens from Children with Clinically Suspected Pertussis

Li, Chi; Huang, Chaoying; Zhang, Ruimu; Wang, Hongmei; Tian, Shufeng; Tang, Yi‐Wei; Deng, Jikui

doi:10.1128/spectrum.01806-22

Microbiol Spectr

2023

DOI: 10.1128/spectrum.01806-22

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Evaluation of BioFire Respiratory Panel 2 plus for Detection of Bordetella pertussis in Nasopharyngeal Swab Specimens from Children with Clinically Suspected Pertussis

Chi Li

Chaoying Huang

Ruimu Zhang

et al.

Abstract: In recent years, there have been some epidemic or local outbreaks of pertussis in countries with high vaccination rates. One of the crucial factors in controlling pertussis is early diagnosis, which is based on specific laboratory measurements, including culture, serological tests, and PCR assays.

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2024

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Cited by 2 publications

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Expert consensus for pertussis in children: new concepts in diagnosis and treatment

Mi,

Deng,

Zhang

et al. 2024

World J Pediatr

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Background Pertussis resurgence has been reported worldwide in the past two decades. Pertussis is still endemic and difficult to control though with universal vaccination in children. The resurgence may be related to multiple variables, such as increased disease awareness and laboratory tests, waning of immunity following vaccination, and/or genetic mutations of Bordetella pertussis. For better pertussis prevention, diagnosis, and management, we called up an expert panel to develop this expert consensus to provide new concepts in diagnosis and treatment for clinical practice. Data sources The expert groups collected clinical evidence, summarized their clinical experiences, evaluated preliminary recommendations or guidelines, and then organized open-ended discussions to form the recommendations. This consensus was developed by reviewing the literature and studies in databases, including PubMed, Cochrane, EMBASE, the China Biomedical Database, and the Chinese Journal Full-text Database up to May 2024. The search terms included “pertussis” or “whooping cough”, “children”, “diagnosis”, and “treatment”. Results The burden of pertussis has also changed from infants to school children and adults, and these age groups have consequently become the main source of infection for vulnerable population including infants and newborns. In China, a high prevalence of erythromycin-resistant Bordetella pertussis (ERBP) has been reported in the past decade. ERBP may lead to failed clinical empirical treatment with macrolides, which poses a great challenge for pertussis management and control. For better management of pertussis, a flow diagram for diagnosis and treatment of pertussis was presented in this consensus. This consensus also described the diagnostic criteria for pertussis, high-risk cases, and severe pertussis. Macrolides can still be used to treat confirmed erythromycin-sensitive B. pertussis (ESBP) infections, whereas oral trimethoprim–sulfamethoxazole therapy is the initial treatment option for children older than two months. For infants younger than two months, severe patients, or those exhibiting a high degree of sulfonamide allergy, intravenous administration of piperacillin or cefoperazone–sulbactam is advised. Conclusions This expert consensus provides a comprehensive guidance and a reference for the diagnosis and treatment of pertussis in children. Graphic abstract

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Expert consensus for pertussis in children: new concepts in diagnosis and treatment

Mi,

Deng,

Zhang

et al. 2024

World J Pediatr

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Features of the course of whooping cough associated with rhinovirus and parainfluenza infections in a young child

Kovaleva,

Lityaeva,

Kaykova

2024

Det. infekc.

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Evaluation of BioFire Respiratory Panel 2 plus for Detection of Bordetella pertussis in Nasopharyngeal Swab Specimens from Children with Clinically Suspected Pertussis

Cited by 2 publications

References 30 publications

Expert consensus for pertussis in children: new concepts in diagnosis and treatment

Expert consensus for pertussis in children: new concepts in diagnosis and treatment

Features of the course of whooping cough associated with rhinovirus and parainfluenza infections in a young child

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