Evaluation of Biological Activities of Extracts and Chemical Constituents of &lt;i&gt;Mimusops elengi&lt;/i&gt;

Amir, Faheem; Wong, KC; Eldeen, I.M.S.; Asmawi, MZ; Osman, Hasnah

doi:10.4314/tjpr.v12i4.22

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…The characterization was compared to established literature [139]. Compound 77 was also identified as possessing moderate antibacterial activity when tested against bacterial strains B. subtilis (ATCC6633), S. aureus (ATCC12600), E. coli (ATCC25922), K. pneumoniae (ATCC13883) and P. stutzeri (ATCC17588), with MIC values of 78 µg/mL for S. aureus (ATCC12600), 156 µg/mL for P. stutzeri (ATCC17588), and 312 µg/mL for all other bacterial strains reported [140].…”

Section: Ursolic Acid Derivativesmentioning

confidence: 99%

Comprehensive Review of the Components in Cat’s Claw (Uncaria tomentosa) and Their Antibacterial Activity

Blanck¹,

Huebner²,

Rolls³

et al. 2022

AppliedChem

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Cat’s claw (Uncaria tomentosa (Willd. ex Schults) DC.), a plant that is exceptionally rich in phytochemicals, has been used for centuries by the indigenous people of South and Central America as a therapeutic and is currently widely exported for medicinal purposes. Extracts and individual components have shown considerable potential as antibacterials in the literature. The purpose of this review is twofold: first, to provide a substantiated, comprehensive collection of the known chemical constituents of U. tomentosa, including their detailed structures; second, to identify those components that offer some promise as antibacterials based on the research to date. Bacterial resistance to currently available antibiotics continues to increase and is widely recognized as an impending, potentially catastrophic, problem. There is research to suggest that U. tomentosa components may have antibacterial potential individually or synergistically with established antibiotics against microbes, including Borrelia burgdorferi, the causative agent of Lyme disease. It is our intention that this review will provide a valuable resource to investigators in search of new antimicrobials to meet the daunting challenge of antibiotic resistance.

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Section: Ursolic Acid Derivativesmentioning

confidence: 99%

Comprehensive Review of the Components in Cat’s Claw (Uncaria tomentosa) and Their Antibacterial Activity

Blanck¹,

Huebner²,

Rolls³

et al. 2022

AppliedChem

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“…To the best of our knowledge, no phytochemical work has so far been carried out on this species. As part of our systematic search for new bioactive lead structures from African medicinal plants, we herein report the isolation from the roots of the plant and structural elucidation of two new triterpenoidal saponins, pachystelanosides A (1) and B (2), as well as six known compounds, taraxeryl acetate [2], taraxerol [3], spinasterol [4], betulinic acid [5], spinasterol-3-O-β-D-glucopyranoside [6], and catechin [7]. 13 C NMR spectra was achieved using COSY, HSQC, and HMBC NMR data (Tables 1 and 2).…”

mentioning

confidence: 99%

Two New Triterpenoidal Saponins from Roots of Pachystela msolo

Ache

Tabopda

Yeboah

et al. 2015

Natural Product Communications

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“…In previous researches, taraxerol was isolated from various plants such as leaves crude extracts of Jatropha tanjorensis [79], Rhizophora mangle and Rhizophora racemose [81], roots crude extract of Taraxacum officinale [82], seed oils of Catharanthus roseus, Nymphaea nelumbo, Casuarina equisetifolia, Acrocarpus fraxinifolius [83] and barks of Cupania dentate [84]. Furthermore, taraxerol was isolated from Sapotaceae family such as seed oils of M. hexandra, leaves of P. ramiflora [45], barks of M. elengi which showed antibacterial activity [85]. Taraxerol has been reported to exhibit antibacterial [85], antigiardial [84], mulluscicidal [28] and antimicrobial activities [86] Compound II was identified by comparison of spectroscopic data with published literature [88].…”

Section: Isolation Of Ethyl Acetate Crude Extract Of Stem Barks Of M ...mentioning

confidence: 99%

“…Furthermore, taraxerol was isolated from Sapotaceae family such as seed oils of M. hexandra, leaves of P. ramiflora [45], barks of M. elengi which showed antibacterial activity [85]. Taraxerol has been reported to exhibit antibacterial [85], antigiardial [84], mulluscicidal [28] and antimicrobial activities [86] Compound II was identified by comparison of spectroscopic data with published literature [88]. The spectrums of DEPT90 (Figure 49), DEPT135 (Figure 50), HSQC (Figure 51) and COSY (Figure 53) were confirmed the structure of compound II.…”

Section: Isolation Of Ethyl Acetate Crude Extract Of Stem Barks Of M ...mentioning

confidence: 99%

Tyrosinase inhibitors from bark of talawrinta (Manilkara Kauki (L.) dubard

Srisupap

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Melanin is essential for protecting human skin from ultraviolet radiation. However, its overproduction in the basal epithelial layer leads to hyperpigmentary disorders of the skin such as melasma, blemish and age spots. Tyrosinase is one of key enzymes in melanogenesis. Manilkara kauki (L.) Dubard or Talawrinta is one of the plants in genus Manilkara of Sapotaceae family. This study attempted to investigate in vitro total phenolic and flavonoid contents, antioxidant and tyrosinase inhibitory activities of crude extract of different parts of M. kauki and purify tyrosinase inhibitors from stem barks of M. kauki. Methanol and aqueous crude extracts of fruits, leaves, seeds, stem barks and woods of M. kauki evaluated on their total phenolic and flavonoid contents, antioxidant and tyrosinase inhibitory activities. Stem barks of M. kauki showed high amount of total phenolic and flavonoid contents and strong antioxidant activity. Methanol crude extracts of stem barks exhibited the highest tyrosinase inhibitory activity (IC?? value of 0.26 ? 0.05 mg/mL). Thus, stem barks of M. kauki was extracted with n-hexane, ethyl acetate, methanol and water, respectively. Both of ethyl acetate and methanol crude extracts of stem barks exhibited high amount of phenolic compounds and flavonoids and strong antioxidant activity. Furthermore, ethyl acetate crude extract of stem bark exhibited higher tyrosinase inhibitory activity than n-hexane, methanol and aqueous crude extracts with IC?? values of 0.24 ? 0.02 and 0.28 ? 0.04 mg/mL for L-tyrosine and L-DOPA as substrates, respectively. Thus, ethyl acetate crude extract was further isolated and purified to afford compound I as taraxerol and compound II as dihydrokaempferol. Compound I exhibited tyrosinase inhibitory activity with IC?? values of 2.32 ? 0.06 and 2.65 ? 0.03 mM for L-tyrosine and L-DOPA as substrates, respectively. Compound II exhibited tyrosinase inhibitory activity with IC?? values of 1.15 ? 0.06 and 1.74 ? 0.05 mM for L-tyrosine and L-DOPA as substrates, respectively. Compounds I and II showed lower tyrosinase inhibitory activity than kojic acid but they were exhibited higher tyrosinase inhibitory activity than ?-arbutin. These results suggested that ethyl acetate crude extract of stem barks of M. kauki should be further investigated for others biological activities including anti-allergic, cytotoxicity and in vivo tyrosinase inhibitory activities to evaluate it before using as a potential ingredient in whitening cosmetics.

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Evaluation of Biological Activities of Extracts and Chemical Constituents of <i>Mimusops elengi</i>

Cited by 6 publications

References 10 publications

Comprehensive Review of the Components in Cat’s Claw (Uncaria tomentosa) and Their Antibacterial Activity

Comprehensive Review of the Components in Cat’s Claw (Uncaria tomentosa) and Their Antibacterial Activity

Two New Triterpenoidal Saponins from Roots of Pachystela msolo

Tyrosinase inhibitors from bark of talawrinta (Manilkara Kauki (L.) dubard

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