Evaluation of Biological Effects of Hydroalcoholic Extract of Hibiscus Rosa Sinensis Flowers on Alloxan Induced Diabetes in Rats

Abstract

The current study sought to investigate antidiabetic, hypolipidimic, antioxidant and histopathological effects of floral extract of Hibiscus rosa sinensis in Alloxan induced Diabetes in rats. Study was conducted on 6 groups with 6 wistar rats in each group for the period of 4 weeks. Group I: served as normal control (NC), rats administered with gum acacia 1 ml daily, group II: consider as diabetic control (DC) treated with alloxon 150 mg/kg body wt. Whereas Hibiscus rosa-sinensis flower extract was given orally in group III (DE1), group IV (DE2), group V (DE3) at doses of 50, 100 and 200 mg/kg body weight dissolved in distilled water respectively. Group VI (DG) was given glibenclamide (5 mg/kg) as a standard drug and results were compared in reference to it. The results indicate that the test compound HEFHR (Hydroalcoholic extract of flower Hibiscus rosa-sinensis) has significant and sustained oral antidiabetic activity, comparable with the hypoglycemic effect of Glibenclamide and Sulphonylurea. Flower extract of HRS was more efficacious in lipid lowering effect and in antioxidative activity than glibenclamide. After 28 day treatment with flower extract, size of islets was significantly increased and necrosis and atrophy of islets were significantly improved; also increase in number and diameter of cell islets appeared to be regular as compared to the diabetic group. HEFHR possesses significant antidiabetic, hypolipidemic and antioxidant properties as well as regeneration of beta cells in rats. Further evaluation of HEFHR is in progress.

Blood lipids lowering effect of medicinal plants

“…Flower extract of HRS was more efficacious in lipid lowering effect and in antioxidative activity than glibenclamide. After 28 day treatment with flower extract, size of islets was significantly increased and necrosis and atrophy of islets were significantly improved; also increase in number and diameter of cell islets compared to the diabetic group (151) . Blood glucose and total lipid levels were determined in Streptozotocin induced diabetic rats after oral administration of an ethanol flower extract of Hibiscus rosa sinensis.…”

Effect of Hibiscus Rosa nanoparticles on sperm parameters of male albino rats

“…Fertility regulation, which includes contraception and infertility management, is an essential component of reproductive health [24][25][26]. The effect of antiandrogens on the reproductive system and fertility of male albino rats was described by Al-Hady [24].…”

Hibiscus rosa-sinensis L. (red Hibiscus) Tea, Can It Be Used as A Home-Remedy to Control Diabetes and Hypercholesterolemia?

“…Further, significant anti-diabetic effects which were comparable to glibenclamide and sulphonylurea were observed with the same dosed administered for 28 days. Histopathological studies showed an increase in the size and number of islets, diameter of the islet cells and decrease in the necrosis and atrophy of the islets (Pethe et al, 2017). After administrating ethanolic Hibiscus flower extract for 21 days, a maximum blood glucose lowering of 41-46% and total cholesterol and serum triglycerides lowering of 22 and 30%, respectively were observed with Streptozotocine induced diabetic rats.…”