Evaluation of biological response modifiers in the enhancement of tumor uptake of technetium-99m labeled macromolecules

Quantitative Tumor Apoptosis Imaging Using Technetium-99m–HYNIC Annexin V Single Photon Emission Computed Tomography

“…If the treatment schedule used does not include the use of biologic response modifiers that are able to increase aspecific diffusion-related tumor uptake of peptides (eg, interferon), the amount of aspecific diffusion-related uptake will be fairly constant from pretherapy to posttherapy scans. 26 Thus, by subtracting pretherapy from posttherapy tumor uptake values, diffusion-related bias on measurements will be minimized. Support in favor of the potential of radiolabeled annexin-V to monitor treatment response derives from both preclinical and ongoing clinical studies.…”

Pyridyl-Cyclopentadiene Re(CO)2+ Complexes as a Compact Core System for SPECT Ligand Development

“…Examples of the use of technetium in imaging include simple complexes such as the myocardial imaging agent Sestamibi, ® 3, 4 as well as technetium-containing complexes appended to biological molecules of interest,5 often macromolecules. 6,7, 8 A commonly used pendent complex is the organometallic cyclopentadienyl tricarbonyl technetium unit, CpTc(CO) 3 , because of its high stability9 and the ease with which it can be prepared 10,11,12. The CpTc(CO) 3 unit works well with high molecular weight biomolecules, whose physical and chemical properties dominate over the relatively small pendant complex.…”

“…Because of its long half-life (6 h) and widespread availability, 99 m Tc is currently used for approximately 85% of all clinical radioisotopic imaging applications. , Examples of the use of technetium in imaging include simple complexes such as the myocardial imaging agent Sestamibi, , as well as technetium-containing complexes appended to biological molecules of interest, often macromolecules. − A commonly used pendent complex is the organometallic cyclopentadienyl tricarbonyl technetium unit, CpTc(CO) 3 , because of its high stability and the ease with which it can be prepared. − The CpTc(CO) 3 unit works well with high molecular weight biomolecules, whose physical and chemical properties dominate over the relatively small pendant complex. With smaller biological molecules and small-molecule drugs, however, the polarity and steric size of the three carbonyl ligands have the potential to negatively affect pharmacokinetic properties.…”