Evaluation of biomarkers of oxidant–antioxidant balance in patients with acne vulgaris

Oxidative Stress in Acne Vulgaris

“…There is no significant association between any of the parameters with age group, disease severity, or disease duration among acne patients. This also agrees with the study of Ibrahim et al [14].…”

“…In another study conducted by M A Ibrahim et al, 40 acne vulgaris patients and 36 age and sex-matched controls are evaluated for oxidant-antioxidant status. A highly significant decrease in SOD and other antioxidant enzyme activity (p-value<0.001) and a highly significant increase in serum MDA (p-value<0.001) were detected in patients compared to healthy controls [14]. Similar results were obtained in a study conducted by G Sarici et al [4].…”

Markers of Oxidative Stress in Patients with Acne: A Literature Review

“…Awad et al did not observe a correlation between the serum levels of MDA, TAS, and zinc and disease severity [59]. Furthermore, Ibrahim et al did not find a correlation between the level of lipid peroxidation assessed by plasma MDA and the activity of erythrocyte G6PD, plasma CAT, and erythrocyte SOD enzymes [63].…”

“…Acne is known to be associated with increased sebum secretion and an increased amount of squalene. In the case of a deficient antioxidant system, the peroxidation of fatty acids in sebum occurs, leading to the activation of an inflammatory process [63]. Studies indicate that lipids are involved in triggering an inflammatory process in several skin diseases such as psoriasis vulgaris, lichen planus, etc.…”

“…Furthermore, the NADPHs generated by G6PD are crucial for synthesizing the reduced forms of glutathione and thioredoxin. These reduced forms of antioxidants play a vital role in regenerating and maintaining an optimal antioxidant status [63].…”