Evaluation of blood vessel network formation and visual field defect in optic disc melanocytoma

Kwak, Jay Jiyong; Lee, Dong Hoon; Lee, Sung Chul; Lee, Christopher S.

doi:10.1136/bjophthalmol-2021-319630

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Multiple modalities, such as optical coherence tomography (OCT), fundus autofluorescence (FAF), fluorescein angiography (FA) and sonography, have been developed and have enabled ophthalmologists to evaluate tumors on diagnosis and follow-up [1,2,[10][11][12]. In recent years, OCT angiography (OCTA) has served as a noninvasive and promising technique for evaluating the microcirculation, providing vascular areas and densities [12][13][14][15][16][17].…”

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confidence: 99%

Ocular circulation change in optic disc melanocytoma – a case report and a review of the literature

Tsai

Chu

et al. 2023

BMC Ophthalmol

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Background Ocular circulation in optic disc melanocytoma (ODM) has not yet been well evaluated. We quantitatively evaluated longitudinal changes in the morphology and circulation hemodynamics of the disc and macula using optical coherence tomography angiography (OCTA) and laser speckle flowgraphy (LSFG) in a patient with optic disc melanocytoma. Case presentation A 50-year-old woman was referred to our hospital due to a dark pigmented tumor over the superior optic disc area of the left eye noted on physical examination. At the first visit, the patient’s best-corrected visual acuity (BCVA) was 20/20 in both eyes, and the intraocular pressure (IOP) was 17 and 18 mmHg in the left and right eyes, respectively. Fluorescein angiography (FA) showed blockage of fluorescence in the topography of the lesion, and indocyanine green angiography (ICGA) showed hypofluorescence at all times. On LSFG, a low mean blur rate (MBR) was noted in the optic disc all area (MBRa) and tissue (MBRt) compared to the contralateral eye at the first visit and at the 3-month follow-up. A relatively low MBR was also detected in the macular area of the affected eye and the tumor itself. OCTA detected blood vessel networks in the deep retinal layer of the tumor. The visual field showed no specific defects. During follow-up, there was no tumor enlargement or vision decrease. Conclusions We found that a lower MBR of the disc and macula area was noted on LSFG in this patient with optic disc melanocytoma, and it was continually observed at the 3-month follow-up. Although blood vessel networks in the deep retinal layer of the tumor were detected by OCTA, vascular compromise in the surrounding disc area and macula was found. Therefore, these results further increase our knowledge about the role that circulation impairment plays in the pathogenesis of the disease while vision is unaffected.

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Section: Introductionmentioning

confidence: 99%

Ocular circulation change in optic disc melanocytoma – a case report and a review of the literature

Tsai

Chu

et al. 2023

BMC Ophthalmol

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Uveal Melanoma: A Review of the Literature and Personal Experiences

Kim

Lee

2021

J Retin

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Uveal melanoma is the most common primary intraocular tumor in adults. The annual incidence rate is approximately 0.42 per million people with an increasing trend in South Korea. Approximately 90% of uveal melanomas occur in the choroid, typically presenting as a dome-shaped mass. Radiotherapy is the mainstay of eye-preserving therapy for primary tumors, and plaque brachytherapy is the most common treatment modality for medium-sized tumors. Although primary tumors respond well to local treatment, systemic metastasis is observed in up to 50% of patients. The most commonly affected organ is the liver. Currently, the underlying mechanism of tumorigenesis and metastasis of the uveal melanoma is poorly understood; there is no effective therapy for metastatic tumors. Recent studies have focused on the oncogenic signaling pathways related to driver mutations in the GNAQ, GNA11, PLCB4, and CYSTLR2 genes. However, most clinical studies applying new targeted therapies failed to improve survival. In this review article, we intend to share clinical experience in Korea, and summarize the latest research on molecular characteristics and targeted therapies for uveal melanoma.

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Evaluation of blood vessel network formation and visual field defect in optic disc melanocytoma

Cited by 2 publications

References 28 publications

Ocular circulation change in optic disc melanocytoma – a case report and a review of the literature

Ocular circulation change in optic disc melanocytoma – a case report and a review of the literature

Uveal Melanoma: A Review of the Literature and Personal Experiences

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