Evaluation of Bmi Relationship With Increased D-Dimer in Covid-19 Patients at a Jakarta Private Hospital

VESSELALDO, MANUEL; Ramatillah, Diana Laila

doi:10.22159/ijap.2022.v14s2.44749

Cited by 3 publications

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“…D-Dimer merupakan degrasi dari fibrin terlarut yang merupakan hasil degradasi sistematis thrombus vascular melalui mekanisme fibrinolitik [6]. Nilai D-Dimer normal pada orang sehat adalah < 500 ng/mL [7,8]. Kemunculan nilai D-Dimer yang tinggi sering dikaitkan dengan masalah pembekuan darah seperti thromboembolism [6,9,10].…”

Section: Pendahuluanunclassified

“…Kemunculan nilai D-Dimer yang tinggi sering dikaitkan dengan masalah pembekuan darah seperti thromboembolism [6,9,10]. Pada beberapa kasus ditemukan bahwa pasien yang memiliki nilai BMI dan umur yang tinggi memiliki nilai D-Dimer yang tinggi [7,11]. Nilai D-Dimer yang tinggi juga ditemukan pada pasien yang memiliki komorbit p < 0.05 tetapi pada penelitian tidak disebutkan jenis komorbit yang menyebabkan peningkatan nilai D-Dimer [12].…”

Section: Pendahuluanunclassified

“…Body Mass Index atau disingkat menjadi BMI merupakan metode pengukuran digunakan untuk menentukan kategori dari berat badan berdasarkan tinggi badan [7]. Pasien Covid-19 dengan BMI yang tinggi sering mengalami hypoxia (kekurangan oxygen) dan peningkatan nilai D-dimer [15].…”

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Hubungan Sosiodemografi dan Penyakit Penyerta Terhadap Nilai D-Dimer Pasien Covid-19

Michael

Ramatillah

Hartuti

2022

JFI

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D-Dimer merupakan degrasi dari fibrin terlarut yang merupakan hasil degradasi sistematis thrombus vascular melalui mekanisme fibrinolitik. Tujuan dari penelitian ini adalah melihat faktor sosiodemografi dan penyakit lain yang mempengaruhi nilai d-dimer dari pasien covid-19. Penelitian ini menggunakan metode retrospective cohort dengan pengumpulan sampling adalah convenience sampling. Terdapat 137 pasien yang memenuhi kriteria penelitian. Umur, BMI, blood pressure dan respiration rate merupakan sociodemografi yang mempengaruhi nilai lab D-dimer. Untuk penyakit penyerta yang mempengaruhi nilai lab D-dimer terdapat CKD, anemia, hipertensi dan penyakit jantung. Nilai D-dimer yang tinggi juga memiliki hubungan yang significant dengan tingkat keparahan dari infeksi covid-19 selain itu pasien yang meninggal ditemukan nilai D-dimer yang tinggi. Penggunaan antikoagulan direkomendasikan untuk pasien dengan nilai D-dimer yang tinggi.

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Section: Pendahuluanunclassified

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Hubungan Sosiodemografi dan Penyakit Penyerta Terhadap Nilai D-Dimer Pasien Covid-19

Michael

Ramatillah

Hartuti

2022

JFI

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Evaluation of Increased Antibody Titer COVID-19 after Astrazeneca Vaccination Based on the Age at UTA'45 Jakarta Vaccine Center

Lukas

Ramatillah²,

Aldi³

et al. 2023

Asian Journal of Pharmaceutical Research and Health Care

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Background: Vaccine is an essential tool to limit the health of the COVID-19 pandemic. AstraZeneca vaccine already provided promising effectiveness data. Still, the study must check the correlation between vaccination and antibody titer. Aim: This study aims to evaluate antibody titer after AstraZeneca vaccination based on the age group. Materials and Methods: This study used a prospective cross-sectional method with convenience sampling. Inclusion criteria were all Indonesian citizens above 18 years old who were vaccinated at UTA'45 Jakarta Vaccine Center with no history of COVID-19 before the vaccination and had filled up the informed consent. Results: This study's total sample was 102 females; 51.90%, residents of Java Island; 91.17% had comorbidities; 50,98%, smokers; 9,80%, alcohol drinker; 9,80%, exercise; 80,39%, blood pressure; 128/73, SpO2: 97,82. Most participants aged around 30 years had a body mass index of 23.33. Age, comorbidity, smoking, alcohol, and exercise habit significantly correlate with the increase of the participants' antibodies (P < 0.001). The age shows that the younger the participant, the higher the titer antibody 2 will be (P = 0.001, 95% confidence interval [CI], −1.935, −0.694). The exercise shows that the participant with the routine practice will have a higher titer antibody 2 (P = 0.002, 95% CI, 12.016, 51.791). Antibody titer for participants younger than 35 years old increased 5.7 times while for participants between 35 and 45 years old was 3.9 times. Another group (>45–55 years old) has shown an improvement in antibody titer at 1.7 times, but the last group (>55 years old) described an increase in antibody titer at 232.3 times. Conclusions: Age, comorbidity, smoking, alcohol, and exercise contributed to the increase in titer antibody 2 value of the AstraZeneca vaccine participants. Participants in the age group <35 years have an excellent immune system.

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The Impact of High D-Dimer on The Clinical Outcome of Covid-19 patients at A Private Hospital in Jakarta

Laila Ramatillah,

Ainah,

Michael

et al. 2023

RJPT

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D-Dimer is a fibrin degradation product as the resultof thrombus degradation by fibrinolysis. Elevated D-dimer in the blood is a presumptive marker of thrombosis. D-dimer levels above 1g/mL are risk factors for poorprognosis in patients with COVID-19. To evaluate the impact of high D-Dimer on the clinical outcome of Covid-19 patients at Private Hospital in Jakarta. A retrospective cohort study with convenience sampling was applied in this study. There were 980 patients but only 320 patients were eligible for inclusion criteria. This study only included confirmed COVID-19 patients who were hospitalized from March to June 2021, and the study was conducted from March to June 2022. The gender of the majority patients as the sample was male, 165 (52%) and 155(48%) female patients with moderate severity. Correlation between D-dimer and clinical outcome of COVID-19 patients using Fisher's exact method showed a higher survival rate of 287(89.7%) patients compared to 33(10.3%) patients who died with a p-value <0.05. The survival analysis for COVID-19 patients using the Kaplan Meier method showed that patients receiving D-dimer <500ng/mL had a median survival rate of about 90% after approximately 21 days of treatments, whereas patients whowere receiving >500 ng/mL had a 50% survival rate after 30 days of treatment. Patients receiving D-dimer <500ng/mL had a survival rate of about 90% after undergoing treatment for approximately 21 days, while patients who had D-dimer>500 ng/mL had a survival rate of about 50% after 30 days of treatment. Anticoagulants were given to almost all patients, roughly 10 percent died during hospitalization with hypercoagulation complications.

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Evaluation of Bmi Relationship With Increased D-Dimer in Covid-19 Patients at a Jakarta Private Hospital

Cited by 3 publications

References 0 publications

Hubungan Sosiodemografi dan Penyakit Penyerta Terhadap Nilai D-Dimer Pasien Covid-19

Hubungan Sosiodemografi dan Penyakit Penyerta Terhadap Nilai D-Dimer Pasien Covid-19

Evaluation of Increased Antibody Titer COVID-19 after Astrazeneca Vaccination Based on the Age at UTA'45 Jakarta Vaccine Center

The Impact of High D-Dimer on The Clinical Outcome of Covid-19 patients at A Private Hospital in Jakarta

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