Evaluation of bone marrow derived mesenchymal stem cells for full-thickness wound healing in comparison to tissue engineered chitosan scaffold in rabbit

Rajabian, Mohammad Hossein; Ghorabi, Gholam Hossein; Geramizadeh, Bita; Sameni, Safoura; Ayatollahi, Maryam

doi:10.1016/j.tice.2016.11.002

Cited by 18 publications

(8 citation statements)

References 33 publications

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“…Since the cells were labeled with PKH26, after regeneration the fluorescent cells were observed in dermis, epidermis, and hair follicles . The regenerative effects of BMSCs on WH are consistent with the results of other similar studies . Furthermore, adipose‐derived MSCs (ADMSCs) are found to be effective in WH studies.…”

Section: Methods To Enhance the Efficacy Of Msc‐based Wound Therapysupporting

confidence: 87%

“…23 The regenerative effects of BMSCs on WH are consistent with the results of other similar studies. 24,25 Furthermore, adiposederived MSCs (ADMSCs) are found to be effective in WH studies. ADMSCs are a suitable source for treating wounds, due to the availability and abundance of fat tissue, and especially due to their potential in secreting wound healing-related factors (e.g., VEGF, KGF, bFGF, HGF, PDGF, collagen I, and fibronectin).…”

Section: Msc Sourcesmentioning

confidence: 99%

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A review on different methods to increase the efficiency of mesenchymal stem cell‐based wound therapy

Shojaei

Rahmati

Dehkordi

2019

Wound Repair Regeneration

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Mesenchymal stem cells (MSCs) accelerate wound healing but the harsh environment of wound site limits the engraftment, retention, and survival rate of transplanted cells. There are multiple approaches that amplify the therapeutic potential of MSCs. The MSCs derived from medical waste material, provide comparable regenerative abilities compared to traditional sources. The application of different scaffolds increases MSC delivery and migration into the wound. The spheroid culture of MSC increases the paracrine effects of the entrapped cells and the secretion of pro‐angiogenic and anti‐inflammatory cytokines. The MSC pretreating and preconditioning enhances the cell migration, proliferation, and survival rate, which lead to higher angiogenesis, re‐epithelialization, wound closure, and granulation tissue formation. Moreover, genetic modification has been performed in order to increase MSC angiogenesis, differentiation potential, as well as the cell life span. Herein, we review the results of aforementioned approaches and provide information accommodating to the continued development of MSC‐based wound therapy in the future.

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Section: Methods To Enhance the Efficacy Of Msc‐based Wound Therapysupporting

confidence: 87%

Section: Msc Sourcesmentioning

confidence: 99%

A review on different methods to increase the efficiency of mesenchymal stem cell‐based wound therapy

Shojaei

Rahmati

Dehkordi

2019

Wound Repair Regeneration

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“…18 Wound healing progresses via various overlapping phases of cell migration, inflammation, angiogenesis, proliferation, and remodeling. 19 , 20 MSCs enhance angiogenesis in the wound healing process. 21 In fact, a study involving MSCs implanted into cutaneous wounds suggested that MSCs increase the levels of vascular endothelial growth factor (VEGF), one of the most potent pro-angiogenic factors, the density of microvessels, and cutaneous wound microcirculation.…”

Section: Introductionmentioning

confidence: 99%

<p>Anti-Inflammatory Effects of Magnetically Targeted Mesenchymal Stem Cells on Laser-Induced Skin Injuries in Rats</p>

Wei

Zhang

et al. 2020

IJN

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Introduction: Mesenchymal stem cells (MSCs) are a promising resource for tissue regeneration and repair. However, their clinical application is hindered by technical limitations related to MSC enrichment at the target sites. Methods: MSCs were labeled with magnetic Fe 3 O 4 nanoparticles (NPs). We analyzed the effects of NP on cell proliferation, stem cell characteristics, and cytokine secretion. Furthermore, we induced NP-labeled MSC migration with an external magnetic field toward laser-induced skin wounds in rats and evaluated the associated anti-inflammatory effects. Results: Fe 3 O 4 NP application did not adversely affect MSC characteristics. Moreover, Fe 3 O 4 NP-labeled MSCs presented increased anti-inflammatory cytokine and chemokine production compared with unlabeled MSCs. Furthermore, MSCs accumulated at the injury site and magnetic targeting promoted NP-labeled MSC migration toward burn injury sites in vivo. On day 7 following MSC injection, reduced inflammation and promoted angiogenesis were observed in the magnetically targeted MSC group. In addition, anti-inflammatory factors were upregulated, whereas pro-inflammatory factors were downregulated within the magnetically targeted MSC group compared with those in the PBS group. Conclusion: This study demonstrates that magnetically targeted MSCs contribute to cell migration to the site of skin injury, improve anti-inflammatory effects and enhance angiogenesis compared with MSC injection alone. Therefore, magnetically targeted MSC therapy may be an effective treatment approach for epithelial tissue injuries.

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“…However, studies also demonstrated that MSC enhanced regeneration was more effective than MSC-conditioned medium alone (Sherman et al, 2017[ 30 ]). In our opinion, MSCs can participate in the skin wound healing and tissue regeneration indirectly through paracrine effect on cells (Lee et al, 2016[ 14 ]) and directly through cellular differentiation towards skin cells such as keratinocytes or pericytes (Isakson et al, 2015[ 12 ]; Rajabian et al, 2017[ 25 ]). The results of the PMSC relative amount in the wounded area showed most intensive signal from all cell groups (Figure 6A and B (Fig.…”

Section: Discussionmentioning

confidence: 99%

Regenerative potential of partially differentiated mesenchymal stromal cells in a mouse model of a full-thickness skin wound

Liubavičiūtė

Kaseta

Vaitkuvienė

et al. 2018

EXCLI Journal; 17:Doc871; ISSN 1611-2156

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Evaluation of bone marrow derived mesenchymal stem cells for full-thickness wound healing in comparison to tissue engineered chitosan scaffold in rabbit

Cited by 18 publications

References 33 publications

A review on different methods to increase the efficiency of mesenchymal stem cell‐based wound therapy

A review on different methods to increase the efficiency of mesenchymal stem cell‐based wound therapy

<p>Anti-Inflammatory Effects of Magnetically Targeted Mesenchymal Stem Cells on Laser-Induced Skin Injuries in Rats</p>

Regenerative potential of partially differentiated mesenchymal stromal cells in a mouse model of a full-thickness skin wound

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