Evaluation of Bone Repair After Periapical Surgeries Using Leukocyte Platelet-Rich Fibrin (L-PRF) and Blood Clot: A Double-Blind Clinical Trial

Abstract

This study evaluated the effectiveness of the use of an autologous membrane of fibrin rich in platelets and leukocytes (LPRF) and blood clot, in bone repair after periapical surgery, in teeth with apical lesions. Methodology: Randomized clinical study of 64 teeth with periapical lesions submitted to apicectomy and retrograde filling with mineral trioxide aggregate (MTA). The teeth were divided into 2 groups according to the filling of the bone pocket: LPRF (n = 34) and only with blood clot (n = 30). The areas were measured twice, T0 after periapical surgery and T1 after 90 days, using cone beam computed tomography (CBCT) to assess bone pocket repair in cubic millimeters using the ITK-SNAP program. Results: Statistical analyses revealed significant reductions in the volume of bone stores in the LPRF group, with a 48.47% reduction compared to 29.25% for the blood clot group (p < 0.01), with the power of test at 99.86%. Conclusion: The use of LPRF membrane can be recommended as a bone site filler after periapical surgery compared to blood clot.