Evaluation of Borderline Ovarian Tumor Recurrence Rate after Surgery with or without Fertility-Sparing Approach: Results of a Retrospective Analysis

Abstract

Borderline ovarian tumors (BOTs) comprise 15–20% of primary ovarian neoplasms and represent an independent disease entity among epithelial ovarian cancers. The present study (Clinical Trial ID: NCT05791838) aimed to report a retrospective analysis of the management and outcomes of 86 consecutive BOTs patients, 54 of which were at a reproductive age. All patients with BOTs undergoing surgical treatment from January 2010 to December 2017 were included. Data were retrospectively reviewed. High levels of Ca-125 were observed in 25.6% of the FIGO stage I patients and 58.3% of the advanced disease patients. Fertility-sparing surgery and comprehensive surgical staging were performed in 36.7% and 49.3% of the patients, respectively. Laparotomy was the most frequent surgical approach (65.1%). The most common diagnosis at frozen sections was serous BOT (50.6%). Serous BOTs have significantly smaller tumor diameters than mucinous BOTs (p < 0.0001). The mean postoperative follow-up was 29.8 months (range 6–87 months). Three patients experienced a recurrence, with an overall recurrence rate of 3.5% (10% considering only the patients who underwent fertility-sparing treatment). BOTs have low recurrence rates, with excellent prognosis. Surgery with proper staging is the main treatment. Conservative surgery is a valid option for women with reproductive potential.

Fertility-sparing surgery in children and adolescents with borderline ovarian tumors: a retrospective study

“…It is acknowledged that conservative surgery can increase the recurrence rate of BOTs [ 26 , 27 ], and a study by Yokoyama et al identified FSS as an independent risk factor for recurrence; radical surgery could reduce that risk [ 17 ]. However, Donna et al reported no tumor-related deaths after recurrence, and a 63.6% pregnancy rate in conservative surgery cases, suggesting that FSS is a viable option for young patients, for whom fertility preservation is a major factor [ 28 ].…”

Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review

“…Over time, this original procedure has evolved into various techniques, including ART, and more recently, laparoscopic and robotic radical trachelectomy (RRT) [3,20,[31][32][33]. Furthermore, FST currently represents a feasible and well-established treatment option for other types of gynecological tumors [34][35][36]. With the implementation of new technologies in surgery [37] and the development and advancements in endoscopic surgery [38,39], minimally invasive treatment is increasingly evolving, becoming a reality.…”

Fertility-sparing surgery in children and adolescents with borderline ovarian tumors: A retrospective study

“…It is acknowledged that conservative surgery can increase the recurrence rate of BOTs 17,18 , and a study by Yokoyama et al identi ed FSS as an independent risk factor for recurrence; radical surgery could reduce that risk 15 . However, Donna et al reported no tumor-related deaths after recurrence, and a 63.6% pregnancy rate in conservative surgery cases, suggesting that FSS is a viable option for young patients, for whom fertility preservation is a major factor 19 .…”