Evaluation of brain atrophy measures in MRI

Atkins, M. Stella; Orchard, Jeff; Tory, Melanie

doi:10.1109/iembs.2001.1019010

Cited by 1 publication

(2 citation statements)

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“…Some studies have made observations about BPF behavior [5,6,7]. For example, slight changes in the segmentation of CSF can influence the BPF dramatically.…”

Section: Introductionmentioning

confidence: 99%

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Robustness of the brain parenchymal fraction for measuring brain atrophy

et al. 2002

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Other researchers have proposed that the brain parenchymal fraction (or brain atrophy) may be a good surrogate measure for disease progression in patients with Multiple Sclerosis. This paper considers various factors influencing the measure of the brain parenchymal fraction obtained from dual spin-echo PD and T2-weighted head MRI scans. We investigate the robustness of the brain parenchymal fraction with respect to two factors: brain-mask border placement which determines the brain intra-dural volume, and brain scan incompleteness. We show that an automatic method for brain segmentation produces an atrophy measure which is fairly sensitive to the brain-mask placement. We also show that a robust, reproducible brain atrophy measure can be obtained from incomplete brain scans, using data in a centrally placed subvolume of the brain.

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“…Some studies have made observations about BPF behavior [5,6,7]. For example, slight changes in the segmentation of CSF can influence the BPF dramatically.…”

Section: Introductionmentioning

confidence: 99%

“…For example, slight changes in the segmentation of CSF can influence the BPF dramatically. However, automatic segmentation of the CSF yields BPF time-series behavior that is highly reproducible [6].…”

Section: Introductionmentioning

confidence: 99%